Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 MPRO

Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 MPRO

Abstract SARS-CoV-2 main protease is a common target for inhibition assays due to its high conservation among coronaviruses. Since flavonoids show antiviral activity, several in silico works have proposed them as potential SARS-CoV-2 main protease inhibitors. Nonetheless, there is reason to doubt ce...

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Autores principales: Gabriel Jiménez-Avalos, A. Paula Vargas-Ruiz, Nicolás E. Delgado-Pease, Gustavo E. Olivos-Ramirez, Patricia Sheen, Manolo Fernández-Díaz, Miguel Quiliano, Mirko Zimic, COVID-19 Working Group in Perú
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/70a95756c88d494c934f01fa64c2c631
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