Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases

High aldosterone levels cause heart damage independently of its well-known effect on blood pressure. Here, Cannavo et al. show that aldosterone-mediated cardiac pathology involves G protein-coupled receptor (GPCR) kinase 2 (GRK2) and GRK5 that integrate signals from angiotensin II receptor (AT1R).

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Autores principales:	Alessandro Cannavo, Daniela Liccardo, Akito Eguchi, Katherine J. Elliott, Christopher J. Traynham, Jessica Ibetti, Satoru Eguchi, Dario Leosco, Nicola Ferrara, Giuseppe Rengo, Walter J. Koch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70ab970e75e145a7b7e6fbb932036a1c
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spelling	oai:doaj.org-article:70ab970e75e145a7b7e6fbb932036a1c2021-12-02T15:34:32ZMyocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases10.1038/ncomms108772041-1723https://doaj.org/article/70ab970e75e145a7b7e6fbb932036a1c2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10877https://doaj.org/toc/2041-1723High aldosterone levels cause heart damage independently of its well-known effect on blood pressure. Here, Cannavo et al. show that aldosterone-mediated cardiac pathology involves G protein-coupled receptor (GPCR) kinase 2 (GRK2) and GRK5 that integrate signals from angiotensin II receptor (AT1R).Alessandro CannavoDaniela LiccardoAkito EguchiKatherine J. ElliottChristopher J. TraynhamJessica IbettiSatoru EguchiDario LeoscoNicola FerraraGiuseppe RengoWalter J. KochNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandro Cannavo Daniela Liccardo Akito Eguchi Katherine J. Elliott Christopher J. Traynham Jessica Ibetti Satoru Eguchi Dario Leosco Nicola Ferrara Giuseppe Rengo Walter J. Koch Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases
description	High aldosterone levels cause heart damage independently of its well-known effect on blood pressure. Here, Cannavo et al. show that aldosterone-mediated cardiac pathology involves G protein-coupled receptor (GPCR) kinase 2 (GRK2) and GRK5 that integrate signals from angiotensin II receptor (AT1R).
format	article
author	Alessandro Cannavo Daniela Liccardo Akito Eguchi Katherine J. Elliott Christopher J. Traynham Jessica Ibetti Satoru Eguchi Dario Leosco Nicola Ferrara Giuseppe Rengo Walter J. Koch
author_facet	Alessandro Cannavo Daniela Liccardo Akito Eguchi Katherine J. Elliott Christopher J. Traynham Jessica Ibetti Satoru Eguchi Dario Leosco Nicola Ferrara Giuseppe Rengo Walter J. Koch
author_sort	Alessandro Cannavo
title	Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases
title_short	Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases
title_full	Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases
title_fullStr	Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases
title_full_unstemmed	Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases
title_sort	myocardial pathology induced by aldosterone is dependent on non-canonical activities of g protein-coupled receptor kinases
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/70ab970e75e145a7b7e6fbb932036a1c
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Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases

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