A new class of rhomboid protease inhibitors discovered by activity-based fluorescence polarization.

Rhomboids are intramembrane serine proteases that play diverse biological roles, including some that are of potential therapeutical relevance. Up to date, rhomboid inhibitor assays are based on protein substrate cleavage. Although rhomboids have an overlapping substrate specificity, substrates canno...

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Autores principales: Eliane V Wolf, Annett Zeißler, Oliver Vosyka, Evelyn Zeiler, Stephan Sieber, Steven H L Verhelst
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/70b1cebe224a4393822bbb3f7abd2254
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