Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals

Abstract To facilitate the precision of clinical electrocardiographic studies of J-to-Tpeak (JTp) and Tpeak-to-Tend (Tpe) intervals, the study investigated their differences between healthy females and males, and between subjects of African and Caucasian origin. In 523 healthy subjects (254 females;...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katerina Hnatkova, Ondřej Toman, Martina Šišáková, Peter Smetana, Katharina M. Huster, Petra Barthel, Tomáš Novotný, Georg Schmidt, Marek Malik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70b386d69d5944fdb9ca8b8f65ee7db9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:70b386d69d5944fdb9ca8b8f65ee7db9
record_format	dspace
spelling	oai:doaj.org-article:70b386d69d5944fdb9ca8b8f65ee7db92021-12-02T13:34:54ZSex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals10.1038/s41598-019-56328-82045-2322https://doaj.org/article/70b386d69d5944fdb9ca8b8f65ee7db92019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56328-8https://doaj.org/toc/2045-2322Abstract To facilitate the precision of clinical electrocardiographic studies of J-to-Tpeak (JTp) and Tpeak-to-Tend (Tpe) intervals, the study investigated their differences between healthy females and males, and between subjects of African and Caucasian origin. In 523 healthy subjects (254 females; 236 subjects of African origin), repeated Holter recordings were used to measure QT, JT, JTp, and Tpe intervals preceded by both stable and variable heart rates. Subject-specific curvilinear regression models were used to obtain individual QTc, JTc, JTpc and Tpec intervals. Rate hysteresis, i.e., the speed with which the intervals adapted after heart rate changes, was also investigated. In all sex-race groups, Tpe intervals were not systematically heart rate dependent. Similar to QTc intervals, women had JTc, and JTpc intervals longer than males (difference 20–30 ms, p < 0.001). However, women had Tpec intervals (and rate uncorrected Tpe intervals) shorter by approximately 10 ms compared to males (p < 0.001). Subjects of African origin had significantly shorter QTc intervals than Caucasians (p < 0.001). Gradually diminishing race-difference was found for JTc, JTpc and Tpec intervals. JTc and JTpc were moderately increasing with age but Tpe/Tpec were not. Rate hysteresis of JTp was approximately 10% longer compared to that of JT (p < 0.001). In future clinical studies, Tpe interval should not be systematically corrected for heart rate and similar to the QT interval, the differences in JT, JTp and Tpe intervals should be corrected for sex. The differences in QT and JT, and JTp intervals should also be corrected for race.Katerina HnatkovaOndřej TomanMartina ŠišákováPeter SmetanaKatharina M. HusterPetra BarthelTomáš NovotnýGeorg SchmidtMarek MalikNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katerina Hnatkova Ondřej Toman Martina Šišáková Peter Smetana Katharina M. Huster Petra Barthel Tomáš Novotný Georg Schmidt Marek Malik Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals
description	Abstract To facilitate the precision of clinical electrocardiographic studies of J-to-Tpeak (JTp) and Tpeak-to-Tend (Tpe) intervals, the study investigated their differences between healthy females and males, and between subjects of African and Caucasian origin. In 523 healthy subjects (254 females; 236 subjects of African origin), repeated Holter recordings were used to measure QT, JT, JTp, and Tpe intervals preceded by both stable and variable heart rates. Subject-specific curvilinear regression models were used to obtain individual QTc, JTc, JTpc and Tpec intervals. Rate hysteresis, i.e., the speed with which the intervals adapted after heart rate changes, was also investigated. In all sex-race groups, Tpe intervals were not systematically heart rate dependent. Similar to QTc intervals, women had JTc, and JTpc intervals longer than males (difference 20–30 ms, p < 0.001). However, women had Tpec intervals (and rate uncorrected Tpe intervals) shorter by approximately 10 ms compared to males (p < 0.001). Subjects of African origin had significantly shorter QTc intervals than Caucasians (p < 0.001). Gradually diminishing race-difference was found for JTc, JTpc and Tpec intervals. JTc and JTpc were moderately increasing with age but Tpe/Tpec were not. Rate hysteresis of JTp was approximately 10% longer compared to that of JT (p < 0.001). In future clinical studies, Tpe interval should not be systematically corrected for heart rate and similar to the QT interval, the differences in JT, JTp and Tpe intervals should be corrected for sex. The differences in QT and JT, and JTp intervals should also be corrected for race.
format	article
author	Katerina Hnatkova Ondřej Toman Martina Šišáková Peter Smetana Katharina M. Huster Petra Barthel Tomáš Novotný Georg Schmidt Marek Malik
author_facet	Katerina Hnatkova Ondřej Toman Martina Šišáková Peter Smetana Katharina M. Huster Petra Barthel Tomáš Novotný Georg Schmidt Marek Malik
author_sort	Katerina Hnatkova
title	Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals
title_short	Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals
title_full	Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals
title_fullStr	Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals
title_full_unstemmed	Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals
title_sort	sex and race differences in j-tend, j-tpeak, and tpeak-tend intervals
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/70b386d69d5944fdb9ca8b8f65ee7db9
work_keys_str_mv	AT katerinahnatkova sexandracedifferencesinjtendjtpeakandtpeaktendintervals AT ondrejtoman sexandracedifferencesinjtendjtpeakandtpeaktendintervals AT martinasisakova sexandracedifferencesinjtendjtpeakandtpeaktendintervals AT petersmetana sexandracedifferencesinjtendjtpeakandtpeaktendintervals AT katharinamhuster sexandracedifferencesinjtendjtpeakandtpeaktendintervals AT petrabarthel sexandracedifferencesinjtendjtpeakandtpeaktendintervals AT tomasnovotny sexandracedifferencesinjtendjtpeakandtpeaktendintervals AT georgschmidt sexandracedifferencesinjtendjtpeakandtpeaktendintervals AT marekmalik sexandracedifferencesinjtendjtpeakandtpeaktendintervals
_version_	1718392743285227520

Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals

Ejemplares similares