Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases

Abstract Background This study aimed to assess the baseline characteristics and clinical outcomes of coronavirus disease 2019 (COVID-19) in pediatric patients with rheumatic and musculoskeletal diseases (RMD) and identify the risk factors associated with symptomatic or severe disease defined as hosp...

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Autores principales:	Daniel Clemente, Clara Udaondo, Jaime de Inocencio, Juan Carlos Nieto, Pilar Galán del Río, Antía García Fernández, Jaime Arroyo Palomo, Javier Bachiller-Corral, Juan Carlos Lopez Robledillo, Claudia Millán Longo, Leticia Leon, Lydia Abasolo, Alina Boteanu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Childhood-onset rheumatic diseases COVID-19 Chronic inflammatory arthritis Autoinflammatory diseases Multisystemic autoimmune disorders Pediatrics RJ1-570 Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/70b401e0b5e542f78a24b6dd938052b3
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spelling	oai:doaj.org-article:70b401e0b5e542f78a24b6dd938052b32021-11-28T12:04:43ZClinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases10.1186/s12969-021-00648-51546-0096https://doaj.org/article/70b401e0b5e542f78a24b6dd938052b32021-11-01T00:00:00Zhttps://doi.org/10.1186/s12969-021-00648-5https://doaj.org/toc/1546-0096Abstract Background This study aimed to assess the baseline characteristics and clinical outcomes of coronavirus disease 2019 (COVID-19) in pediatric patients with rheumatic and musculoskeletal diseases (RMD) and identify the risk factors associated with symptomatic or severe disease defined as hospital admission, intensive care admission or death. Methods An observational longitudinal study was conducted during the first year of the SARS-CoV-2 pandemic (March 2020–March 2021). All pediatric patients attended at the rheumatology outpatient clinics of six tertiary referral hospitals in Madrid, Spain, with a diagnosis of RMD and COVID-19 were included. Main outcomes were symptomatic disease and hospital admission. The covariates were sociodemographic and clinical characteristics and treatment regimens. We ran a multivariable logistic regression model to assess associated factors for outcomes. Results The study population included 77 pediatric patients. Mean age was 11.88 (4.04) years Of these, 30 patients (38.96%) were asymptomatic, 41 (53.25%) had a mild-moderate COVID-19 and 6 patients (7.79%) required hospital admission. The median length of hospital admission was 5 (2–20) days, one patient required intensive care and there were no deaths. Previous comorbidities increased the risk for symptomatic disease and hospital admission. Compared with outpatients, the factor independently associated with hospital admission was previous use of glucocorticoids (OR 3.51; p = 0.00). No statistically significant risk factors for symptomatic COVID-19 were found in the final model. Conclusion No differences in COVID-19 outcomes according to childhood-onset rheumatic disease types were found. Results suggest that associated comorbidities and treatment with glucocorticoids increase the risk of hospital admission.Daniel ClementeClara UdaondoJaime de InocencioJuan Carlos NietoPilar Galán del RíoAntía García FernándezJaime Arroyo PalomoJavier Bachiller-CorralJuan Carlos Lopez RobledilloClaudia Millán LongoLeticia LeonLydia AbasoloAlina BoteanuBMCarticleChildhood-onset rheumatic diseasesCOVID-19Chronic inflammatory arthritisAutoinflammatory diseasesMultisystemic autoimmune disordersPediatricsRJ1-570Diseases of the musculoskeletal systemRC925-935ENPediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Childhood-onset rheumatic diseases COVID-19 Chronic inflammatory arthritis Autoinflammatory diseases Multisystemic autoimmune disorders Pediatrics RJ1-570 Diseases of the musculoskeletal system RC925-935
spellingShingle	Childhood-onset rheumatic diseases COVID-19 Chronic inflammatory arthritis Autoinflammatory diseases Multisystemic autoimmune disorders Pediatrics RJ1-570 Diseases of the musculoskeletal system RC925-935 Daniel Clemente Clara Udaondo Jaime de Inocencio Juan Carlos Nieto Pilar Galán del Río Antía García Fernández Jaime Arroyo Palomo Javier Bachiller-Corral Juan Carlos Lopez Robledillo Claudia Millán Longo Leticia Leon Lydia Abasolo Alina Boteanu Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases
description	Abstract Background This study aimed to assess the baseline characteristics and clinical outcomes of coronavirus disease 2019 (COVID-19) in pediatric patients with rheumatic and musculoskeletal diseases (RMD) and identify the risk factors associated with symptomatic or severe disease defined as hospital admission, intensive care admission or death. Methods An observational longitudinal study was conducted during the first year of the SARS-CoV-2 pandemic (March 2020–March 2021). All pediatric patients attended at the rheumatology outpatient clinics of six tertiary referral hospitals in Madrid, Spain, with a diagnosis of RMD and COVID-19 were included. Main outcomes were symptomatic disease and hospital admission. The covariates were sociodemographic and clinical characteristics and treatment regimens. We ran a multivariable logistic regression model to assess associated factors for outcomes. Results The study population included 77 pediatric patients. Mean age was 11.88 (4.04) years Of these, 30 patients (38.96%) were asymptomatic, 41 (53.25%) had a mild-moderate COVID-19 and 6 patients (7.79%) required hospital admission. The median length of hospital admission was 5 (2–20) days, one patient required intensive care and there were no deaths. Previous comorbidities increased the risk for symptomatic disease and hospital admission. Compared with outpatients, the factor independently associated with hospital admission was previous use of glucocorticoids (OR 3.51; p = 0.00). No statistically significant risk factors for symptomatic COVID-19 were found in the final model. Conclusion No differences in COVID-19 outcomes according to childhood-onset rheumatic disease types were found. Results suggest that associated comorbidities and treatment with glucocorticoids increase the risk of hospital admission.
format	article
author	Daniel Clemente Clara Udaondo Jaime de Inocencio Juan Carlos Nieto Pilar Galán del Río Antía García Fernández Jaime Arroyo Palomo Javier Bachiller-Corral Juan Carlos Lopez Robledillo Claudia Millán Longo Leticia Leon Lydia Abasolo Alina Boteanu
author_facet	Daniel Clemente Clara Udaondo Jaime de Inocencio Juan Carlos Nieto Pilar Galán del Río Antía García Fernández Jaime Arroyo Palomo Javier Bachiller-Corral Juan Carlos Lopez Robledillo Claudia Millán Longo Leticia Leon Lydia Abasolo Alina Boteanu
author_sort	Daniel Clemente
title	Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases
title_short	Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases
title_full	Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases
title_fullStr	Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases
title_full_unstemmed	Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases
title_sort	clinical characteristics and covid-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases
publisher	BMC
publishDate	2021
url	https://doaj.org/article/70b401e0b5e542f78a24b6dd938052b3
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Clinical characteristics and COVID-19 outcomes in a regional cohort of pediatric patients with rheumatic diseases

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