Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats

Abstract Both social environment and genetic factors are critical for smoking initiation and nicotine addiction. We reported that rats developed conditioned flavor (i.e., taste and odor) aversion to intravenously self-administered (IVSA) nicotine, and that social learning promoted nicotine IVSA with...

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Auteurs principaux:	Wenyan Han, Tengfei Wang, Hao Chen
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/70b48e995ffd4189a6cdfdba0af811d6
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spelling	oai:doaj.org-article:70b48e995ffd4189a6cdfdba0af811d62021-12-02T11:52:36ZSocial learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats10.1038/s41598-017-08291-52045-2322https://doaj.org/article/70b48e995ffd4189a6cdfdba0af811d62017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08291-5https://doaj.org/toc/2045-2322Abstract Both social environment and genetic factors are critical for smoking initiation and nicotine addiction. We reported that rats developed conditioned flavor (i.e., taste and odor) aversion to intravenously self-administered (IVSA) nicotine, and that social learning promoted nicotine IVSA with flavor cues. We thus tested the hypothesis that socially acquired nicotine IVSA is a heritable trait by using female rats of six inbred strains and six F1 hybrids. Each strain was tested for 10 daily IVSA sessions. We found that the intake of nicotine (15 and 30 μg/kg/inf) varied among these strains by 33.7–56.6-fold. The heritability of nicotine intake was estimated to be 0.54–0.65. Further, there was a strong correlation in nicotine intake (R2 = 0.85, p < 0.0001) between the two nicotine doses. Another cohort of rats was given three daily IVSA sessions followed by five sessions that tested conditioned flavor aversion. Nicotine intake was highly correlated with the extinction of the conditioned aversion (R2 = 0.58, p < 0.005). These data showed that nicotine intake in the socially acquired nicotine self-administration model is controlled by genetic factors and that the role of social learning is likely in facilitating the extinction of conditioned aversive response to nicotine.Wenyan HanTengfei WangHao ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wenyan Han Tengfei Wang Hao Chen Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats
description	Abstract Both social environment and genetic factors are critical for smoking initiation and nicotine addiction. We reported that rats developed conditioned flavor (i.e., taste and odor) aversion to intravenously self-administered (IVSA) nicotine, and that social learning promoted nicotine IVSA with flavor cues. We thus tested the hypothesis that socially acquired nicotine IVSA is a heritable trait by using female rats of six inbred strains and six F1 hybrids. Each strain was tested for 10 daily IVSA sessions. We found that the intake of nicotine (15 and 30 μg/kg/inf) varied among these strains by 33.7–56.6-fold. The heritability of nicotine intake was estimated to be 0.54–0.65. Further, there was a strong correlation in nicotine intake (R2 = 0.85, p < 0.0001) between the two nicotine doses. Another cohort of rats was given three daily IVSA sessions followed by five sessions that tested conditioned flavor aversion. Nicotine intake was highly correlated with the extinction of the conditioned aversion (R2 = 0.58, p < 0.005). These data showed that nicotine intake in the socially acquired nicotine self-administration model is controlled by genetic factors and that the role of social learning is likely in facilitating the extinction of conditioned aversive response to nicotine.
format	article
author	Wenyan Han Tengfei Wang Hao Chen
author_facet	Wenyan Han Tengfei Wang Hao Chen
author_sort	Wenyan Han
title	Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats
title_short	Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats
title_full	Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats
title_fullStr	Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats
title_full_unstemmed	Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats
title_sort	social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/70b48e995ffd4189a6cdfdba0af811d6
work_keys_str_mv	AT wenyanhan sociallearningpromotesnicotineselfadministrationbyfacilitatingtheextinctionofconditionedaversioninisogenicstrainsofrats AT tengfeiwang sociallearningpromotesnicotineselfadministrationbyfacilitatingtheextinctionofconditionedaversioninisogenicstrainsofrats AT haochen sociallearningpromotesnicotineselfadministrationbyfacilitatingtheextinctionofconditionedaversioninisogenicstrainsofrats
_version_	1718394990947729408

Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats

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