Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study

Abstract Knee symptomatic osteoarthritis (SxOA) was associated with all-cause mortality. Walking disability and NSAIDs use have been postulated as potential mechanisms linking knee SxOA to all-cause mortality. Data were collected on ability of walking for 1 kilometer and use of NSAIDs at baseline an...

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Autores principales:	Qiang Liu, Jingbo Niu, Hu Li, Yan Ke, Rujun Li, Yuqing Zhang, Jianhao Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70b7f5adda74463386679c658595c67c
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spelling	oai:doaj.org-article:70b7f5adda74463386679c658595c67c2021-12-02T16:08:23ZKnee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study10.1038/s41598-017-03110-32045-2322https://doaj.org/article/70b7f5adda74463386679c658595c67c2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03110-3https://doaj.org/toc/2045-2322Abstract Knee symptomatic osteoarthritis (SxOA) was associated with all-cause mortality. Walking disability and NSAIDs use have been postulated as potential mechanisms linking knee SxOA to all-cause mortality. Data were collected on ability of walking for 1 kilometer and use of NSAIDs at baseline and death information at follow-up. Subjects with knee SxOA were identified if at least one knee had both radiographic OA and pain. We first fitted a Cox proportional hazards model to examine the relation of knee SxOA to the risk of all-cause mortality. We then used marginal structural models to decompose total effect of knee SxOA on all-cause mortality into indirect and direct effects via walking disability and use of NSAIDs, respectively. Among 1025 subjects, 99 died over 8 years of follow-up. A multivariable adjusted hazard ratio of mortality for SxOA was 1.98 (95% CI: 1.09–3.62). The indirect effect of knee SxOA on all-cause mortality through either a walking disability or NSAIDs use was 1.92 (95% CI: 0.86–4.26) and 1.45 (95% CI: 0.72–2.92), respectively. The corresponding direct effect was 1.08 (95% CI: 0.55–1.12) and 1.35 (95% CI: 0.75–2.44). In this population-based cohort study, high all-cause mortality from knee SxOA was mediated mainly through a walking disability.Qiang LiuJingbo NiuHu LiYan KeRujun LiYuqing ZhangJianhao LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiang Liu Jingbo Niu Hu Li Yan Ke Rujun Li Yuqing Zhang Jianhao Lin Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study
description	Abstract Knee symptomatic osteoarthritis (SxOA) was associated with all-cause mortality. Walking disability and NSAIDs use have been postulated as potential mechanisms linking knee SxOA to all-cause mortality. Data were collected on ability of walking for 1 kilometer and use of NSAIDs at baseline and death information at follow-up. Subjects with knee SxOA were identified if at least one knee had both radiographic OA and pain. We first fitted a Cox proportional hazards model to examine the relation of knee SxOA to the risk of all-cause mortality. We then used marginal structural models to decompose total effect of knee SxOA on all-cause mortality into indirect and direct effects via walking disability and use of NSAIDs, respectively. Among 1025 subjects, 99 died over 8 years of follow-up. A multivariable adjusted hazard ratio of mortality for SxOA was 1.98 (95% CI: 1.09–3.62). The indirect effect of knee SxOA on all-cause mortality through either a walking disability or NSAIDs use was 1.92 (95% CI: 0.86–4.26) and 1.45 (95% CI: 0.72–2.92), respectively. The corresponding direct effect was 1.08 (95% CI: 0.55–1.12) and 1.35 (95% CI: 0.75–2.44). In this population-based cohort study, high all-cause mortality from knee SxOA was mediated mainly through a walking disability.
format	article
author	Qiang Liu Jingbo Niu Hu Li Yan Ke Rujun Li Yuqing Zhang Jianhao Lin
author_facet	Qiang Liu Jingbo Niu Hu Li Yan Ke Rujun Li Yuqing Zhang Jianhao Lin
author_sort	Qiang Liu
title	Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study
title_short	Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study
title_full	Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study
title_fullStr	Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study
title_full_unstemmed	Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study
title_sort	knee symptomatic osteoarthritis, walking disability, nsaids use and all-cause mortality: population-based wuchuan osteoarthritis study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/70b7f5adda74463386679c658595c67c
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_version_	1718384536093458432

Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study

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