Genetics of COVID-19

COVID-19 is characterized by a wide range of clinical manifestations, from asymptomatic to extremely severe. At the onset of the pandemic, it became clear that old age and chronic illness were the major risk factors. However, they do not fully explain the variety of symptoms and complications of the...

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Autores principales:	Dmitry A. Vologzhanin, Alexandr S. Golota, Tatyana A. Kamilova, Olga V. Shneider, Sergey G. Sherbak
Formato:	article
Lenguaje:	RU
Publicado:	Eco-vector 2021
Materias:	covid-19 coronavirus sars-cov-2 genetic predisposition factors mutation polymorphism Medicine R
Acceso en línea:	https://doaj.org/article/70b81a14e3014ba9937da64d9d094417
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spelling	oai:doaj.org-article:70b81a14e3014ba9937da64d9d0944172021-11-30T18:15:21ZGenetics of COVID-192220-30952618-862710.17816/clinpract64972https://doaj.org/article/70b81a14e3014ba9937da64d9d0944172021-03-01T00:00:00Zhttps://journals.eco-vector.com/clinpractice/article/viewFile/64972/pdfhttps://doaj.org/toc/2220-3095https://doaj.org/toc/2618-8627COVID-19 is characterized by a wide range of clinical manifestations, from asymptomatic to extremely severe. At the onset of the pandemic, it became clear that old age and chronic illness were the major risk factors. However, they do not fully explain the variety of symptoms and complications of the SARS-COV-2 coronavirus infection. The research on genetic risk factors for COVID-19 is still at its early stages. A number of mutations and polymorphisms have been identified that affect the structure and stability of proteins factors of susceptibility to SARS-COV-2 infection, as well as a predisposition to the development of respiratory failure and the need for intensive care. Most of the identified genetic factors are related to the function of the immune system. On the other hand, the genetic polymorphism of the virus itself affects the COVID-19 spread and severity of its course . The genome of the virus accumulates mutations and evolves towards increasing contagiousness, replicative ability and evasion from the host's immune system. Genetic determinants of the COVID-19 infection are potential therapeutic targets. Studying them will provide information for the development of drugs and vaccines to combat the pandemic.Dmitry A. VologzhaninAlexandr S. GolotaTatyana A. KamilovaOlga V. ShneiderSergey G. SherbakEco-vectorarticlecovid-19coronavirussars-cov-2genetic predisposition factorsmutationpolymorphismMedicineRRUКлиническая практика , Vol 12, Iss 1, Pp 41-52 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	covid-19 coronavirus sars-cov-2 genetic predisposition factors mutation polymorphism Medicine R
spellingShingle	covid-19 coronavirus sars-cov-2 genetic predisposition factors mutation polymorphism Medicine R Dmitry A. Vologzhanin Alexandr S. Golota Tatyana A. Kamilova Olga V. Shneider Sergey G. Sherbak Genetics of COVID-19
description	COVID-19 is characterized by a wide range of clinical manifestations, from asymptomatic to extremely severe. At the onset of the pandemic, it became clear that old age and chronic illness were the major risk factors. However, they do not fully explain the variety of symptoms and complications of the SARS-COV-2 coronavirus infection. The research on genetic risk factors for COVID-19 is still at its early stages. A number of mutations and polymorphisms have been identified that affect the structure and stability of proteins factors of susceptibility to SARS-COV-2 infection, as well as a predisposition to the development of respiratory failure and the need for intensive care. Most of the identified genetic factors are related to the function of the immune system. On the other hand, the genetic polymorphism of the virus itself affects the COVID-19 spread and severity of its course . The genome of the virus accumulates mutations and evolves towards increasing contagiousness, replicative ability and evasion from the host's immune system. Genetic determinants of the COVID-19 infection are potential therapeutic targets. Studying them will provide information for the development of drugs and vaccines to combat the pandemic.
format	article
author	Dmitry A. Vologzhanin Alexandr S. Golota Tatyana A. Kamilova Olga V. Shneider Sergey G. Sherbak
author_facet	Dmitry A. Vologzhanin Alexandr S. Golota Tatyana A. Kamilova Olga V. Shneider Sergey G. Sherbak
author_sort	Dmitry A. Vologzhanin
title	Genetics of COVID-19
title_short	Genetics of COVID-19
title_full	Genetics of COVID-19
title_fullStr	Genetics of COVID-19
title_full_unstemmed	Genetics of COVID-19
title_sort	genetics of covid-19
publisher	Eco-vector
publishDate	2021
url	https://doaj.org/article/70b81a14e3014ba9937da64d9d094417
work_keys_str_mv	AT dmitryavologzhanin geneticsofcovid19 AT alexandrsgolota geneticsofcovid19 AT tatyanaakamilova geneticsofcovid19 AT olgavshneider geneticsofcovid19 AT sergeygsherbak geneticsofcovid19
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Genetics of COVID-19

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