BAIAP2 is related to emotional modulation of human memory strength.

Memory performance is the result of many distinct mental processes, such as memory encoding, forgetting, and modulation of memory strength by emotional arousal. These processes, which are subserved by partly distinct molecular profiles, are not always amenable to direct observation. Therefore, compu...

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Autores principales:	Gediminas Luksys, Sandra Ackermann, David Coynel, Matthias Fastenrath, Leo Gschwind, Angela Heck, Bjoern Rasch, Klara Spalek, Christian Vogler, Andreas Papassotiropoulos, Dominique de Quervain
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70b9de39c61a46f49a5f7434b167380d
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spelling	oai:doaj.org-article:70b9de39c61a46f49a5f7434b167380d2021-11-18T08:39:09ZBAIAP2 is related to emotional modulation of human memory strength.1932-620310.1371/journal.pone.0083707https://doaj.org/article/70b9de39c61a46f49a5f7434b167380d2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24392092/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Memory performance is the result of many distinct mental processes, such as memory encoding, forgetting, and modulation of memory strength by emotional arousal. These processes, which are subserved by partly distinct molecular profiles, are not always amenable to direct observation. Therefore, computational models can be used to make inferences about specific mental processes and to study their genetic underpinnings. Here we combined a computational model-based analysis of memory-related processes with high density genetic information derived from a genome-wide study in healthy young adults. After identifying the best-fitting model for a verbal memory task and estimating the best-fitting individual cognitive parameters, we found a common variant in the gene encoding the brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) that was related to the model parameter reflecting modulation of verbal memory strength by negative valence. We also observed an association between the same genetic variant and a similar emotional modulation phenotype in a different population performing a picture memory task. Furthermore, using functional neuroimaging we found robust genotype-dependent differences in activity of the parahippocampal cortex that were specifically related to successful memory encoding of negative versus neutral information. Finally, we analyzed cortical gene expression data of 193 deceased subjects and detected significant BAIAP2 genotype-dependent differences in BAIAP2 mRNA levels. Our findings suggest that model-based dissociation of specific cognitive parameters can improve the understanding of genetic underpinnings of human learning and memory.Gediminas LuksysSandra AckermannDavid CoynelMatthias FastenrathLeo GschwindAngela HeckBjoern RaschKlara SpalekChristian VoglerAndreas PapassotiropoulosDominique de QuervainPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e83707 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gediminas Luksys Sandra Ackermann David Coynel Matthias Fastenrath Leo Gschwind Angela Heck Bjoern Rasch Klara Spalek Christian Vogler Andreas Papassotiropoulos Dominique de Quervain BAIAP2 is related to emotional modulation of human memory strength.
description	Memory performance is the result of many distinct mental processes, such as memory encoding, forgetting, and modulation of memory strength by emotional arousal. These processes, which are subserved by partly distinct molecular profiles, are not always amenable to direct observation. Therefore, computational models can be used to make inferences about specific mental processes and to study their genetic underpinnings. Here we combined a computational model-based analysis of memory-related processes with high density genetic information derived from a genome-wide study in healthy young adults. After identifying the best-fitting model for a verbal memory task and estimating the best-fitting individual cognitive parameters, we found a common variant in the gene encoding the brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) that was related to the model parameter reflecting modulation of verbal memory strength by negative valence. We also observed an association between the same genetic variant and a similar emotional modulation phenotype in a different population performing a picture memory task. Furthermore, using functional neuroimaging we found robust genotype-dependent differences in activity of the parahippocampal cortex that were specifically related to successful memory encoding of negative versus neutral information. Finally, we analyzed cortical gene expression data of 193 deceased subjects and detected significant BAIAP2 genotype-dependent differences in BAIAP2 mRNA levels. Our findings suggest that model-based dissociation of specific cognitive parameters can improve the understanding of genetic underpinnings of human learning and memory.
format	article
author	Gediminas Luksys Sandra Ackermann David Coynel Matthias Fastenrath Leo Gschwind Angela Heck Bjoern Rasch Klara Spalek Christian Vogler Andreas Papassotiropoulos Dominique de Quervain
author_facet	Gediminas Luksys Sandra Ackermann David Coynel Matthias Fastenrath Leo Gschwind Angela Heck Bjoern Rasch Klara Spalek Christian Vogler Andreas Papassotiropoulos Dominique de Quervain
author_sort	Gediminas Luksys
title	BAIAP2 is related to emotional modulation of human memory strength.
title_short	BAIAP2 is related to emotional modulation of human memory strength.
title_full	BAIAP2 is related to emotional modulation of human memory strength.
title_fullStr	BAIAP2 is related to emotional modulation of human memory strength.
title_full_unstemmed	BAIAP2 is related to emotional modulation of human memory strength.
title_sort	baiap2 is related to emotional modulation of human memory strength.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/70b9de39c61a46f49a5f7434b167380d
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BAIAP2 is related to emotional modulation of human memory strength.

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