The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.

Dopamine neurotransmission influences approach toward rewards and reward-related cues. The best cited interpretation of this effect proposes that dopamine mediates the pleasure that commonly accompanies reward. This hypothesis has received support in some animal models and a few studies in humans. H...

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Autores principales:	John Liggins, Robert O Pihl, Chawki Benkelfat, Marco Leyton
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70bc03d8831d43fd8708d9fb10a14e90
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spelling	oai:doaj.org-article:70bc03d8831d43fd8708d9fb10a14e902021-11-18T07:31:01ZThe dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.1932-620310.1371/journal.pone.0028370https://doaj.org/article/70bc03d8831d43fd8708d9fb10a14e902012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22238577/?tool=EBIhttps://doaj.org/toc/1932-6203Dopamine neurotransmission influences approach toward rewards and reward-related cues. The best cited interpretation of this effect proposes that dopamine mediates the pleasure that commonly accompanies reward. This hypothesis has received support in some animal models and a few studies in humans. However, direct assessments of the effect of transiently increasing dopamine neurotransmission have been largely limited to the use of psychostimulant drugs, which elevate brain levels of multiple neurotransmitters in addition to dopamine. In the present study we tested the effect of more selectively elevating dopamine neurotransmission, as produced by administration of the immediate dopamine precursor, L-DOPA (0, 100/25, 200/50 mg, Sinemet), in healthy human volunteers. Neither dose altered positive mood. The results suggest that dopamine neurotransmission does not directly influence positive mood in humans.John LigginsRobert O PihlChawki BenkelfatMarco LeytonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e28370 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q John Liggins Robert O Pihl Chawki Benkelfat Marco Leyton The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.
description	Dopamine neurotransmission influences approach toward rewards and reward-related cues. The best cited interpretation of this effect proposes that dopamine mediates the pleasure that commonly accompanies reward. This hypothesis has received support in some animal models and a few studies in humans. However, direct assessments of the effect of transiently increasing dopamine neurotransmission have been largely limited to the use of psychostimulant drugs, which elevate brain levels of multiple neurotransmitters in addition to dopamine. In the present study we tested the effect of more selectively elevating dopamine neurotransmission, as produced by administration of the immediate dopamine precursor, L-DOPA (0, 100/25, 200/50 mg, Sinemet), in healthy human volunteers. Neither dose altered positive mood. The results suggest that dopamine neurotransmission does not directly influence positive mood in humans.
format	article
author	John Liggins Robert O Pihl Chawki Benkelfat Marco Leyton
author_facet	John Liggins Robert O Pihl Chawki Benkelfat Marco Leyton
author_sort	John Liggins
title	The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.
title_short	The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.
title_full	The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.
title_fullStr	The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.
title_full_unstemmed	The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.
title_sort	dopamine augmenter l-dopa does not affect positive mood in healthy human volunteers.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/70bc03d8831d43fd8708d9fb10a14e90
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The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.

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