RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping

Abstract Fluorescence optical imaging techniques have revolutionized the field of cardiac electrophysiology and advanced our understanding of complex electrical activities such as arrhythmias. However, traditional monocular optical mapping systems, despite having high spatial resolution, are restric...

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Autores principales:	Christopher Gloschat, Kedar Aras, Shubham Gupta, N. Rokhaya Faye, Hanyu Zhang, Roman A. Syunyaev, Roman A. Pryamonosov, Jack Rogers, Matthew W. Kay, Igor R. Efimov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70bc0e7be04648999f28d6ad5de86916
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spelling	oai:doaj.org-article:70bc0e7be04648999f28d6ad5de869162021-12-02T15:09:10ZRHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping10.1038/s41598-018-21333-w2045-2322https://doaj.org/article/70bc0e7be04648999f28d6ad5de869162018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21333-whttps://doaj.org/toc/2045-2322Abstract Fluorescence optical imaging techniques have revolutionized the field of cardiac electrophysiology and advanced our understanding of complex electrical activities such as arrhythmias. However, traditional monocular optical mapping systems, despite having high spatial resolution, are restricted to a two-dimensional (2D) field of view. Consequently, tracking complex three-dimensional (3D) electrical waves such as during ventricular fibrillation is challenging as the waves rapidly move in and out of the field of view. This problem has been solved by panoramic imaging which uses multiple cameras to measure the electrical activity from the entire epicardial surface. However, the diverse engineering skill set and substantial resource cost required to design and implement this solution have made it largely inaccessible to the biomedical research community at large. To address this barrier to entry, we present an open source toolkit for building panoramic optical mapping systems which includes the 3D printing of perfusion and imaging hardware, as well as software for data processing and analysis. In this paper, we describe the toolkit and demonstrate it on different mammalian hearts: mouse, rat, and rabbit.Christopher GloschatKedar ArasShubham GuptaN. Rokhaya FayeHanyu ZhangRoman A. SyunyaevRoman A. PryamonosovJack RogersMatthew W. KayIgor R. EfimovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christopher Gloschat Kedar Aras Shubham Gupta N. Rokhaya Faye Hanyu Zhang Roman A. Syunyaev Roman A. Pryamonosov Jack Rogers Matthew W. Kay Igor R. Efimov RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping
description	Abstract Fluorescence optical imaging techniques have revolutionized the field of cardiac electrophysiology and advanced our understanding of complex electrical activities such as arrhythmias. However, traditional monocular optical mapping systems, despite having high spatial resolution, are restricted to a two-dimensional (2D) field of view. Consequently, tracking complex three-dimensional (3D) electrical waves such as during ventricular fibrillation is challenging as the waves rapidly move in and out of the field of view. This problem has been solved by panoramic imaging which uses multiple cameras to measure the electrical activity from the entire epicardial surface. However, the diverse engineering skill set and substantial resource cost required to design and implement this solution have made it largely inaccessible to the biomedical research community at large. To address this barrier to entry, we present an open source toolkit for building panoramic optical mapping systems which includes the 3D printing of perfusion and imaging hardware, as well as software for data processing and analysis. In this paper, we describe the toolkit and demonstrate it on different mammalian hearts: mouse, rat, and rabbit.
format	article
author	Christopher Gloschat Kedar Aras Shubham Gupta N. Rokhaya Faye Hanyu Zhang Roman A. Syunyaev Roman A. Pryamonosov Jack Rogers Matthew W. Kay Igor R. Efimov
author_facet	Christopher Gloschat Kedar Aras Shubham Gupta N. Rokhaya Faye Hanyu Zhang Roman A. Syunyaev Roman A. Pryamonosov Jack Rogers Matthew W. Kay Igor R. Efimov
author_sort	Christopher Gloschat
title	RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping
title_short	RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping
title_full	RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping
title_fullStr	RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping
title_full_unstemmed	RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping
title_sort	rhythm: an open source imaging toolkit for cardiac panoramic optical mapping
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/70bc0e7be04648999f28d6ad5de86916
work_keys_str_mv	AT christophergloschat rhythmanopensourceimagingtoolkitforcardiacpanoramicopticalmapping AT kedararas rhythmanopensourceimagingtoolkitforcardiacpanoramicopticalmapping AT shubhamgupta rhythmanopensourceimagingtoolkitforcardiacpanoramicopticalmapping AT nrokhayafaye rhythmanopensourceimagingtoolkitforcardiacpanoramicopticalmapping AT hanyuzhang rhythmanopensourceimagingtoolkitforcardiacpanoramicopticalmapping AT romanasyunyaev rhythmanopensourceimagingtoolkitforcardiacpanoramicopticalmapping AT romanapryamonosov rhythmanopensourceimagingtoolkitforcardiacpanoramicopticalmapping AT jackrogers rhythmanopensourceimagingtoolkitforcardiacpanoramicopticalmapping AT matthewwkay rhythmanopensourceimagingtoolkitforcardiacpanoramicopticalmapping AT igorrefimov rhythmanopensourceimagingtoolkitforcardiacpanoramicopticalmapping
_version_	1718387880570650624

RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping

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