Opportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies

Glycosylation is a ubiquitous process that is universally conserved in nature. The various products of glycosylation, such as polysaccharides, glycoproteins, and glycolipids, perform a myriad of intra- and extracellular functions. The multitude of roles performed by these molecules is reflected in t...

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Autores principales:	Liubov Yakovlieva, Julius A. Fülleborn, Marthe T. C. Walvoort
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pathogenic bacteria glycosylation antivirulence antibacterial strategies metabolic oligosaccharide engineering Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/70bc16c0fcb040a7a5c79b8bae373db7
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spelling	oai:doaj.org-article:70bc16c0fcb040a7a5c79b8bae373db72021-11-18T10:59:26ZOpportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies1664-302X10.3389/fmicb.2021.745702https://doaj.org/article/70bc16c0fcb040a7a5c79b8bae373db72021-09-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.745702/fullhttps://doaj.org/toc/1664-302XGlycosylation is a ubiquitous process that is universally conserved in nature. The various products of glycosylation, such as polysaccharides, glycoproteins, and glycolipids, perform a myriad of intra- and extracellular functions. The multitude of roles performed by these molecules is reflected in the significant diversity of glycan structures and linkages found in eukaryotes and prokaryotes. Importantly, glycosylation is highly relevant for the virulence of many bacterial pathogens. Various surface-associated glycoconjugates have been identified in bacteria that promote infectious behavior and survival in the host through motility, adhesion, molecular mimicry, and immune system manipulation. Interestingly, bacterial glycosylation systems that produce these virulence factors frequently feature rare monosaccharides and unusual glycosylation mechanisms. Owing to their marked difference from human glycosylation, bacterial glycosylation systems constitute promising antibacterial targets. With the rise of antibiotic resistance and depletion of the antibiotic pipeline, novel drug targets are urgently needed. Bacteria-specific glycosylation systems are especially promising for antivirulence therapies that do not eliminate a bacterial population, but rather alleviate its pathogenesis. In this review, we describe a selection of unique glycosylation systems in bacterial pathogens and their role in bacterial homeostasis and infection, with a focus on virulence factors. In addition, recent advances to inhibit the enzymes involved in these glycosylation systems and target the bacterial glycan structures directly will be highlighted. Together, this review provides an overview of the current status and promise for the future of using bacterial glycosylation to develop novel antibacterial strategies.Liubov YakovlievaJulius A. FüllebornMarthe T. C. WalvoortFrontiers Media S.A.articlepathogenic bacteriaglycosylationantivirulenceantibacterial strategiesmetabolic oligosaccharide engineeringMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pathogenic bacteria glycosylation antivirulence antibacterial strategies metabolic oligosaccharide engineering Microbiology QR1-502
spellingShingle	pathogenic bacteria glycosylation antivirulence antibacterial strategies metabolic oligosaccharide engineering Microbiology QR1-502 Liubov Yakovlieva Julius A. Fülleborn Marthe T. C. Walvoort Opportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies
description	Glycosylation is a ubiquitous process that is universally conserved in nature. The various products of glycosylation, such as polysaccharides, glycoproteins, and glycolipids, perform a myriad of intra- and extracellular functions. The multitude of roles performed by these molecules is reflected in the significant diversity of glycan structures and linkages found in eukaryotes and prokaryotes. Importantly, glycosylation is highly relevant for the virulence of many bacterial pathogens. Various surface-associated glycoconjugates have been identified in bacteria that promote infectious behavior and survival in the host through motility, adhesion, molecular mimicry, and immune system manipulation. Interestingly, bacterial glycosylation systems that produce these virulence factors frequently feature rare monosaccharides and unusual glycosylation mechanisms. Owing to their marked difference from human glycosylation, bacterial glycosylation systems constitute promising antibacterial targets. With the rise of antibiotic resistance and depletion of the antibiotic pipeline, novel drug targets are urgently needed. Bacteria-specific glycosylation systems are especially promising for antivirulence therapies that do not eliminate a bacterial population, but rather alleviate its pathogenesis. In this review, we describe a selection of unique glycosylation systems in bacterial pathogens and their role in bacterial homeostasis and infection, with a focus on virulence factors. In addition, recent advances to inhibit the enzymes involved in these glycosylation systems and target the bacterial glycan structures directly will be highlighted. Together, this review provides an overview of the current status and promise for the future of using bacterial glycosylation to develop novel antibacterial strategies.
format	article
author	Liubov Yakovlieva Julius A. Fülleborn Marthe T. C. Walvoort
author_facet	Liubov Yakovlieva Julius A. Fülleborn Marthe T. C. Walvoort
author_sort	Liubov Yakovlieva
title	Opportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies
title_short	Opportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies
title_full	Opportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies
title_fullStr	Opportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies
title_full_unstemmed	Opportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies
title_sort	opportunities and challenges of bacterial glycosylation for the development of novel antibacterial strategies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/70bc16c0fcb040a7a5c79b8bae373db7
work_keys_str_mv	AT liubovyakovlieva opportunitiesandchallengesofbacterialglycosylationforthedevelopmentofnovelantibacterialstrategies AT juliusafulleborn opportunitiesandchallengesofbacterialglycosylationforthedevelopmentofnovelantibacterialstrategies AT marthetcwalvoort opportunitiesandchallengesofbacterialglycosylationforthedevelopmentofnovelantibacterialstrategies
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Opportunities and Challenges of Bacterial Glycosylation for the Development of Novel Antibacterial Strategies

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