Potential of Bioactive Compounds of Arenga Vinegar as Traditional Medicine Through Reverse Docking Techniques

Background: Arenga vinegar (Arenga pinnata) has been trusted by the indigenous people of Kampung Kuta as traditional medicine, one of which is used as a diabetes medicine. For this reason, the aim of this study is to examine the bioactive compounds contained in arenga vinegar, namely acetic acid, wh...

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Autores principales:	Diana Hernawati, Reza Fauzi Dwisandi, Egi Nuryadin
Formato:	article
Lenguaje:	EN ID
Publicado:	Department of Biology Education, Faculty of Teacher Training and Education, Universitas Muhammadiyah 2021
Materias:	arenga vinegar bioactive compound reverse docking Education L Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/70bc33ac33774717930857333ea12b00
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spelling	oai:doaj.org-article:70bc33ac33774717930857333ea12b002021-11-22T13:45:14ZPotential of Bioactive Compounds of Arenga Vinegar as Traditional Medicine Through Reverse Docking Techniques2614-154X2614-155810.22236/j.bes/526802https://doaj.org/article/70bc33ac33774717930857333ea12b002021-08-01T00:00:00Zhttps://journal.uhamka.ac.id/index.php/bioeduscience/article/view/6802https://doaj.org/toc/2614-154Xhttps://doaj.org/toc/2614-1558Background: Arenga vinegar (Arenga pinnata) has been trusted by the indigenous people of Kampung Kuta as traditional medicine, one of which is used as a diabetes medicine. For this reason, the aim of this study is to examine the bioactive compounds contained in arenga vinegar, namely acetic acid, which is predicted to be scientifically proven using reverse docking techniques. Methods: This research is descriptive qualitative research, by interpreting the data obtained from databases and software. Results: There is a binding pose between acetic acid and the sucrase-isomaltase enzyme, the lowest binding affinity value is -3.2 kcal/mol, and the binding site occurs hydrophobic interactions with the amino acids Trp327 (A), Asp355 (A), Ile392 (A), Trp470 (A), Phe604 (A), His629 (A), Trp586 (A) as well as hydrogen bonding to the amino acid Asp(472)A. Conclusions: The acetic acid-binding pose binds well to the sucrase-isomaltase enzyme so that the binding affinity value appears even though the value is not too low and the binding site occurs, this can be used as proof of the belief of the indigenous people of Kampung Kuta, namely the treatment of arenga vinegar as a diabetes drug, especially as a level control blood sugar.Diana HernawatiReza Fauzi DwisandiEgi NuryadinDepartment of Biology Education, Faculty of Teacher Training and Education, Universitas Muhammadiyaharticlearenga vinegarbioactive compoundreverse dockingEducationLBiology (General)QH301-705.5ENIDBioeduscience, Vol 5, Iss 2, Pp 142-147 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	arenga vinegar bioactive compound reverse docking Education L Biology (General) QH301-705.5
spellingShingle	arenga vinegar bioactive compound reverse docking Education L Biology (General) QH301-705.5 Diana Hernawati Reza Fauzi Dwisandi Egi Nuryadin Potential of Bioactive Compounds of Arenga Vinegar as Traditional Medicine Through Reverse Docking Techniques
description	Background: Arenga vinegar (Arenga pinnata) has been trusted by the indigenous people of Kampung Kuta as traditional medicine, one of which is used as a diabetes medicine. For this reason, the aim of this study is to examine the bioactive compounds contained in arenga vinegar, namely acetic acid, which is predicted to be scientifically proven using reverse docking techniques. Methods: This research is descriptive qualitative research, by interpreting the data obtained from databases and software. Results: There is a binding pose between acetic acid and the sucrase-isomaltase enzyme, the lowest binding affinity value is -3.2 kcal/mol, and the binding site occurs hydrophobic interactions with the amino acids Trp327 (A), Asp355 (A), Ile392 (A), Trp470 (A), Phe604 (A), His629 (A), Trp586 (A) as well as hydrogen bonding to the amino acid Asp(472)A. Conclusions: The acetic acid-binding pose binds well to the sucrase-isomaltase enzyme so that the binding affinity value appears even though the value is not too low and the binding site occurs, this can be used as proof of the belief of the indigenous people of Kampung Kuta, namely the treatment of arenga vinegar as a diabetes drug, especially as a level control blood sugar.
format	article
author	Diana Hernawati Reza Fauzi Dwisandi Egi Nuryadin
author_facet	Diana Hernawati Reza Fauzi Dwisandi Egi Nuryadin
author_sort	Diana Hernawati
title	Potential of Bioactive Compounds of Arenga Vinegar as Traditional Medicine Through Reverse Docking Techniques
title_short	Potential of Bioactive Compounds of Arenga Vinegar as Traditional Medicine Through Reverse Docking Techniques
title_full	Potential of Bioactive Compounds of Arenga Vinegar as Traditional Medicine Through Reverse Docking Techniques
title_fullStr	Potential of Bioactive Compounds of Arenga Vinegar as Traditional Medicine Through Reverse Docking Techniques
title_full_unstemmed	Potential of Bioactive Compounds of Arenga Vinegar as Traditional Medicine Through Reverse Docking Techniques
title_sort	potential of bioactive compounds of arenga vinegar as traditional medicine through reverse docking techniques
publisher	Department of Biology Education, Faculty of Teacher Training and Education, Universitas Muhammadiyah
publishDate	2021
url	https://doaj.org/article/70bc33ac33774717930857333ea12b00
work_keys_str_mv	AT dianahernawati potentialofbioactivecompoundsofarengavinegarastraditionalmedicinethroughreversedockingtechniques AT rezafauzidwisandi potentialofbioactivecompoundsofarengavinegarastraditionalmedicinethroughreversedockingtechniques AT eginuryadin potentialofbioactivecompoundsofarengavinegarastraditionalmedicinethroughreversedockingtechniques
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Potential of Bioactive Compounds of Arenga Vinegar as Traditional Medicine Through Reverse Docking Techniques

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