Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study

Introduction: Drug-drug interaction is one of the causes of adverse drug reactions. Generally, drug-drug interaction is common in multidrug therapy. Diabetic patients, particularly due to associated comorbidities tend to have various drug-drug interactions due to the effect of multiple drugs. The o...

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Autores principales:	Lujaw Ratna Tuladhar, Shirish Lal Shrestha, Sneha Bimali, Srijana Bhusal, Pingala Khadka
Formato:	article
Lenguaje:	EN
Publicado:	Nepal Medical Association 2021
Materias:	diabetes mellitus; drug interactions; hypoglycemic agents. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/70bf1083d35c4bddb7c91f6bfbb43b45
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spelling	oai:doaj.org-article:70bf1083d35c4bddb7c91f6bfbb43b452021-11-18T19:19:50ZDrug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study10.31729/jnma.70800028-27151815-672Xhttps://doaj.org/article/70bf1083d35c4bddb7c91f6bfbb43b452021-11-01T00:00:00Zhttp://www.jnma.com.np/jnma/index.php/jnma/article/view/7080https://doaj.org/toc/0028-2715https://doaj.org/toc/1815-672X Introduction: Drug-drug interaction is one of the causes of adverse drug reactions. Generally, drug-drug interaction is common in multidrug therapy. Diabetic patients, particularly due to associated comorbidities tend to have various drug-drug interactions due to the effect of multiple drugs. The objective of this study was to find out the prevalence of drug-drug interactions in diabetic patients. Methods: It was a descriptive cross-sectional study that was conducted among previously diagnosed diabetic patients visiting the outpatient department of medicine at a tertiary care hospital between March 2021 and August 2021. Ethical approval was taken from the institutional review committee (Ref no: 030-076/077). Data was collected from diabetic patients presenting to the outpatient department of medicine using a preformed self-constructed questionnaire. Convenient sampling was done. Statistical Package for Social Sciences version 21 and Microsoft Excel were used for data analysis. Point estimate at 95% confidence interval was calculated along with frequency and proportion for binary data. Results: The prevalence of drug-drug interaction between hypoglycemic and non-hypoglycemic medication was 56 (44.1%) (35.5-52.7 at 95% Confidence Interval) of the patients out of which at least one drug-drug interaction was seen in 48 (37.8%) of the patients. Conclusions: Our study showed the prevalence of drug-drug interactions in diabetic patients to be higher than other studies done in similar settings. Based on the severity, we observed two types of drug-drug interactions; close monitoring drug-drug interactions and minor drug-drug interactions. Lujaw Ratna TuladharShirish Lal ShresthaSneha BimaliSrijana BhusalPingala KhadkaNepal Medical Associationarticlediabetes mellitus; drug interactions; hypoglycemic agents.Medicine (General)R5-920ENJournal of Nepal Medical Association, Vol 59, Iss 243 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus; drug interactions; hypoglycemic agents. Medicine (General) R5-920
spellingShingle	diabetes mellitus; drug interactions; hypoglycemic agents. Medicine (General) R5-920 Lujaw Ratna Tuladhar Shirish Lal Shrestha Sneha Bimali Srijana Bhusal Pingala Khadka Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study
description	Introduction: Drug-drug interaction is one of the causes of adverse drug reactions. Generally, drug-drug interaction is common in multidrug therapy. Diabetic patients, particularly due to associated comorbidities tend to have various drug-drug interactions due to the effect of multiple drugs. The objective of this study was to find out the prevalence of drug-drug interactions in diabetic patients. Methods: It was a descriptive cross-sectional study that was conducted among previously diagnosed diabetic patients visiting the outpatient department of medicine at a tertiary care hospital between March 2021 and August 2021. Ethical approval was taken from the institutional review committee (Ref no: 030-076/077). Data was collected from diabetic patients presenting to the outpatient department of medicine using a preformed self-constructed questionnaire. Convenient sampling was done. Statistical Package for Social Sciences version 21 and Microsoft Excel were used for data analysis. Point estimate at 95% confidence interval was calculated along with frequency and proportion for binary data. Results: The prevalence of drug-drug interaction between hypoglycemic and non-hypoglycemic medication was 56 (44.1%) (35.5-52.7 at 95% Confidence Interval) of the patients out of which at least one drug-drug interaction was seen in 48 (37.8%) of the patients. Conclusions: Our study showed the prevalence of drug-drug interactions in diabetic patients to be higher than other studies done in similar settings. Based on the severity, we observed two types of drug-drug interactions; close monitoring drug-drug interactions and minor drug-drug interactions.
format	article
author	Lujaw Ratna Tuladhar Shirish Lal Shrestha Sneha Bimali Srijana Bhusal Pingala Khadka
author_facet	Lujaw Ratna Tuladhar Shirish Lal Shrestha Sneha Bimali Srijana Bhusal Pingala Khadka
author_sort	Lujaw Ratna Tuladhar
title	Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study
title_short	Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study
title_full	Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study
title_fullStr	Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study
title_full_unstemmed	Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study
title_sort	drug-drug interactions between hypoglycemic and non-hypoglycemic medication in diabetic patients with comorbidities in a tertiary care center: a descriptive cross-sectional study
publisher	Nepal Medical Association
publishDate	2021
url	https://doaj.org/article/70bf1083d35c4bddb7c91f6bfbb43b45
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Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study

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