CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES

Our understanding of anticancer immune surveillance currently serves as a basis for development of novel therapies that utilize patient’s own immune system as an anticancer agent. Previously, cancer immunotherapy mostly included non-specific immunomodulating agents, cytokines, or cancer cell-based t...

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Autores principales:	Yu. N. Lezhnin, A. Yu. Khristichenko, N. M. Ratnikova, Yu. E. Kravchenko, S. P. Chumakov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	сellular immunotherapy therapeutic antibodies adoptive immunotherapy cancer vaccine chimeric antigen receptor Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/70bf3e70f41f401cb4a13e41f51b4853
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spelling	oai:doaj.org-article:70bf3e70f41f401cb4a13e41f51b48532021-11-18T08:03:47ZCELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES1563-06252313-741X10.15789/1563-0625-2018-3-313-340https://doaj.org/article/70bf3e70f41f401cb4a13e41f51b48532018-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1535https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XOur understanding of anticancer immune surveillance currently serves as a basis for development of novel therapies that utilize patient’s own immune system as an anticancer agent. Previously, cancer immunotherapy mostly included non-specific immunomodulating agents, cytokines, or cancer cell-based tumor vaccines. Emerging understanding of diverse interactions between the immune system and cancer cells allows to develop novel, more effective therapeutic approaches that target only specific populations of immune cells. Recent studies focus on testing efficiency of allogenic and authologous anticancer immunity, strategies for ex vivo expansion of these cells, and approaches to increase their anticancer activity and specificity. Most recent approaches focus on re-targeting immune cells to specific tumor antigens, shifting the balance of immunosuppressive tumor microenvironment towards immune stimulation and utilizing immune cells to target tumor architecture. This review is focused on the prospects of different immuno-therapeutic strategies.Yu. N. LezhninA. Yu. KhristichenkoN. M. RatnikovaYu. E. KravchenkoS. P. ChumakovSPb RAACIarticleсellular immunotherapytherapeutic antibodiesadoptive immunotherapycancer vaccinechimeric antigen receptorImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 3, Pp 313-340 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	сellular immunotherapy therapeutic antibodies adoptive immunotherapy cancer vaccine chimeric antigen receptor Immunologic diseases. Allergy RC581-607
spellingShingle	сellular immunotherapy therapeutic antibodies adoptive immunotherapy cancer vaccine chimeric antigen receptor Immunologic diseases. Allergy RC581-607 Yu. N. Lezhnin A. Yu. Khristichenko N. M. Ratnikova Yu. E. Kravchenko S. P. Chumakov CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES
description	Our understanding of anticancer immune surveillance currently serves as a basis for development of novel therapies that utilize patient’s own immune system as an anticancer agent. Previously, cancer immunotherapy mostly included non-specific immunomodulating agents, cytokines, or cancer cell-based tumor vaccines. Emerging understanding of diverse interactions between the immune system and cancer cells allows to develop novel, more effective therapeutic approaches that target only specific populations of immune cells. Recent studies focus on testing efficiency of allogenic and authologous anticancer immunity, strategies for ex vivo expansion of these cells, and approaches to increase their anticancer activity and specificity. Most recent approaches focus on re-targeting immune cells to specific tumor antigens, shifting the balance of immunosuppressive tumor microenvironment towards immune stimulation and utilizing immune cells to target tumor architecture. This review is focused on the prospects of different immuno-therapeutic strategies.
format	article
author	Yu. N. Lezhnin A. Yu. Khristichenko N. M. Ratnikova Yu. E. Kravchenko S. P. Chumakov
author_facet	Yu. N. Lezhnin A. Yu. Khristichenko N. M. Ratnikova Yu. E. Kravchenko S. P. Chumakov
author_sort	Yu. N. Lezhnin
title	CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES
title_short	CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES
title_full	CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES
title_fullStr	CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES
title_full_unstemmed	CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES
title_sort	cellular immunotherapy: a modern approach to treatment of oncological diseases
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/70bf3e70f41f401cb4a13e41f51b4853
work_keys_str_mv	AT yunlezhnin cellularimmunotherapyamodernapproachtotreatmentofoncologicaldiseases AT ayukhristichenko cellularimmunotherapyamodernapproachtotreatmentofoncologicaldiseases AT nmratnikova cellularimmunotherapyamodernapproachtotreatmentofoncologicaldiseases AT yuekravchenko cellularimmunotherapyamodernapproachtotreatmentofoncologicaldiseases AT spchumakov cellularimmunotherapyamodernapproachtotreatmentofoncologicaldiseases
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CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES

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