Ocular Complications After Radiation Therapy: An Observational Study

Raffaele Nuzzi,1 Marta Trossarello,1 Sara Bartoncini,2 Paola Marolo,1 Pierfrancesco Franco,2 Cristina Mantovani,2 Umberto Ricardi2 1Department of Surgical Sciences, Ophthalmology/Eye Clinic, University of Turin, Turin, Italy; 2Department of Oncology, University of Turin, Turin, ItalyCorrespondence:...

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Autores principales:	Nuzzi R, Trossarello M, Bartoncini S, Marolo P, Franco P, Mantovani C, Ricardi U
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	eye radiotherapy orbital lymphoma nasopharyngeal carcinoma meningioma secondary / iatrogenic pathology. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/70bff629d02a42c3a9e2dc749c28c67a
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spelling	oai:doaj.org-article:70bff629d02a42c3a9e2dc749c28c67a2021-12-02T12:18:17ZOcular Complications After Radiation Therapy: An Observational Study1177-5483https://doaj.org/article/70bff629d02a42c3a9e2dc749c28c67a2020-10-01T00:00:00Zhttps://www.dovepress.com/ocular-complications-after-radiation-therapy-an-observational-study-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Raffaele Nuzzi,1 Marta Trossarello,1 Sara Bartoncini,2 Paola Marolo,1 Pierfrancesco Franco,2 Cristina Mantovani,2 Umberto Ricardi2 1Department of Surgical Sciences, Ophthalmology/Eye Clinic, University of Turin, Turin, Italy; 2Department of Oncology, University of Turin, Turin, ItalyCorrespondence: Raffaele NuzziDipartimento di Scienze Chirurgiche, Ophthalmology/Eye Clinic, University of Turin, Oculistica U, Via Cherasco 23, Turin 10126, ItalyTel +39 368 203 493Email raffaele.nuzzi@unito.itAim of the Study: The study aims to quantify the incidence of ocular complications in patients irradiated on the head and neck area in our medical center, stratified by type of neoplasm and radiation dose received.Materials and Methods: From an existing database of patients radio-treated in our center, we selected 25 patients irradiated in the 2011– 2018 period. The patients had been treated for orbital lymphoma, nasopharyngeal carcinoma and cranial base meningioma. The selected patients received an ophthalmologic evaluation which included a complete ophthalmological and orthoptic assessment.Results: Our results showed a significantly higher incidence of DES (dry eye syndrome) and corneal complications for eyes receiving a Dmax higher than 40 Gy, as well as for cataract incidence in eyes that had received a Dmax to the lens higher than 5 Gy. We found an overall thinning of the RNFL (retinal nerve fiber layer) in eyes that had received a Dmax higher than 50 Gy, as well as a greater MD (mean deviation) from normal visual field values.Conclusion: In conclusion, we can say that the study confirms the presence of a correlation between the received radiation dose and the onset of eye complications, despite the small sample.Keywords: eye, radiotherapy, orbital lymphoma, nasopharyngeal carcinoma, meningioma, secondary/iatrogenic pathologyNuzzi RTrossarello MBartoncini SMarolo PFranco PMantovani CRicardi UDove Medical Pressarticleeyeradiotherapyorbital lymphomanasopharyngeal carcinomameningiomasecondary / iatrogenic pathology.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3153-3166 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	eye radiotherapy orbital lymphoma nasopharyngeal carcinoma meningioma secondary / iatrogenic pathology. Ophthalmology RE1-994
spellingShingle	eye radiotherapy orbital lymphoma nasopharyngeal carcinoma meningioma secondary / iatrogenic pathology. Ophthalmology RE1-994 Nuzzi R Trossarello M Bartoncini S Marolo P Franco P Mantovani C Ricardi U Ocular Complications After Radiation Therapy: An Observational Study
description	Raffaele Nuzzi,1 Marta Trossarello,1 Sara Bartoncini,2 Paola Marolo,1 Pierfrancesco Franco,2 Cristina Mantovani,2 Umberto Ricardi2 1Department of Surgical Sciences, Ophthalmology/Eye Clinic, University of Turin, Turin, Italy; 2Department of Oncology, University of Turin, Turin, ItalyCorrespondence: Raffaele NuzziDipartimento di Scienze Chirurgiche, Ophthalmology/Eye Clinic, University of Turin, Oculistica U, Via Cherasco 23, Turin 10126, ItalyTel +39 368 203 493Email raffaele.nuzzi@unito.itAim of the Study: The study aims to quantify the incidence of ocular complications in patients irradiated on the head and neck area in our medical center, stratified by type of neoplasm and radiation dose received.Materials and Methods: From an existing database of patients radio-treated in our center, we selected 25 patients irradiated in the 2011– 2018 period. The patients had been treated for orbital lymphoma, nasopharyngeal carcinoma and cranial base meningioma. The selected patients received an ophthalmologic evaluation which included a complete ophthalmological and orthoptic assessment.Results: Our results showed a significantly higher incidence of DES (dry eye syndrome) and corneal complications for eyes receiving a Dmax higher than 40 Gy, as well as for cataract incidence in eyes that had received a Dmax to the lens higher than 5 Gy. We found an overall thinning of the RNFL (retinal nerve fiber layer) in eyes that had received a Dmax higher than 50 Gy, as well as a greater MD (mean deviation) from normal visual field values.Conclusion: In conclusion, we can say that the study confirms the presence of a correlation between the received radiation dose and the onset of eye complications, despite the small sample.Keywords: eye, radiotherapy, orbital lymphoma, nasopharyngeal carcinoma, meningioma, secondary/iatrogenic pathology
format	article
author	Nuzzi R Trossarello M Bartoncini S Marolo P Franco P Mantovani C Ricardi U
author_facet	Nuzzi R Trossarello M Bartoncini S Marolo P Franco P Mantovani C Ricardi U
author_sort	Nuzzi R
title	Ocular Complications After Radiation Therapy: An Observational Study
title_short	Ocular Complications After Radiation Therapy: An Observational Study
title_full	Ocular Complications After Radiation Therapy: An Observational Study
title_fullStr	Ocular Complications After Radiation Therapy: An Observational Study
title_full_unstemmed	Ocular Complications After Radiation Therapy: An Observational Study
title_sort	ocular complications after radiation therapy: an observational study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/70bff629d02a42c3a9e2dc749c28c67a
work_keys_str_mv	AT nuzzir ocularcomplicationsafterradiationtherapyanobservationalstudy AT trossarellom ocularcomplicationsafterradiationtherapyanobservationalstudy AT bartoncinis ocularcomplicationsafterradiationtherapyanobservationalstudy AT marolop ocularcomplicationsafterradiationtherapyanobservationalstudy AT francop ocularcomplicationsafterradiationtherapyanobservationalstudy AT mantovanic ocularcomplicationsafterradiationtherapyanobservationalstudy AT ricardiu ocularcomplicationsafterradiationtherapyanobservationalstudy
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Ocular Complications After Radiation Therapy: An Observational Study

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