DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously

DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously

Bispecific antibodies can bind to two distinct targets though the fusion of two different Fv regions. In this study, the authors develop DutaFabs that present two separated and independent antigen binding sites within the same Fv region, giving rise to bispecific Fab fragments.

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Autores principales: Roland Beckmann, Kristian Jensen, Sebastian Fenn, Janina Speck, Katrin Krause, Anastasia Meier, Melanie Röth, Sascha Fauser, Raymond Kimbung, Derek T. Logan, Martin Steegmaier, Hubert Kettenberger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/70c0f8f5eaae4c48be3ad457ee0a7a4b
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spelling oai:doaj.org-article:70c0f8f5eaae4c48be3ad457ee0a7a4b2021-12-02T13:57:44ZDutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously10.1038/s41467-021-20949-32041-1723https://doaj.org/article/70c0f8f5eaae4c48be3ad457ee0a7a4b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20949-3https://doaj.org/toc/2041-1723Bispecific antibodies can bind to two distinct targets though the fusion of two different Fv regions. In this study, the authors develop DutaFabs that present two separated and independent antigen binding sites within the same Fv region, giving rise to bispecific Fab fragments.Roland BeckmannKristian JensenSebastian FennJanina SpeckKatrin KrauseAnastasia MeierMelanie RöthSascha FauserRaymond KimbungDerek T. LoganMartin SteegmaierHubert KettenbergerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Roland Beckmann
Kristian Jensen
Sebastian Fenn
Janina Speck
Katrin Krause
Anastasia Meier
Melanie Röth
Sascha Fauser
Raymond Kimbung
Derek T. Logan
Martin Steegmaier
Hubert Kettenberger
DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
description Bispecific antibodies can bind to two distinct targets though the fusion of two different Fv regions. In this study, the authors develop DutaFabs that present two separated and independent antigen binding sites within the same Fv region, giving rise to bispecific Fab fragments.
format article
author Roland Beckmann
Kristian Jensen
Sebastian Fenn
Janina Speck
Katrin Krause
Anastasia Meier
Melanie Röth
Sascha Fauser
Raymond Kimbung
Derek T. Logan
Martin Steegmaier
Hubert Kettenberger
author_facet Roland Beckmann
Kristian Jensen
Sebastian Fenn
Janina Speck
Katrin Krause
Anastasia Meier
Melanie Röth
Sascha Fauser
Raymond Kimbung
Derek T. Logan
Martin Steegmaier
Hubert Kettenberger
author_sort Roland Beckmann
title DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
title_short DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
title_full DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
title_fullStr DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
title_full_unstemmed DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously
title_sort dutafabs are engineered therapeutic fab fragments that can bind two targets simultaneously
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/70c0f8f5eaae4c48be3ad457ee0a7a4b
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