DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously

DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously

Bispecific antibodies can bind to two distinct targets though the fusion of two different Fv regions. In this study, the authors develop DutaFabs that present two separated and independent antigen binding sites within the same Fv region, giving rise to bispecific Fab fragments.

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Detalles Bibliográficos
Autores principales: Roland Beckmann, Kristian Jensen, Sebastian Fenn, Janina Speck, Katrin Krause, Anastasia Meier, Melanie Röth, Sascha Fauser, Raymond Kimbung, Derek T. Logan, Martin Steegmaier, Hubert Kettenberger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/70c0f8f5eaae4c48be3ad457ee0a7a4b
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