Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation

Diffuse intrinsic pontine gliomas exhibit a characteristic mutation of lysine 27 to methionine (K27M) in genes encoding histone H3.3. Here the authors show that the H3.3K27M mutation imposes a specific pattern of H3.3K27 methylation by altering the target search dynamics of PcG proteins.

Guardado en:

Detalles Bibliográficos
Autores principales:	Roubina Tatavosian, Huy Nguyen Duc, Thao Ngoc Huynh, Dong Fang, Benjamin Schmitt, Xiaodong Shi, Yiming Deng, Christopher Phiel, Tingting Yao, Zhiguo Zhang, Haobin Wang, Xiaojun Ren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70c84502ebb94488990d301031f7915f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:70c84502ebb94488990d301031f7915f
record_format	dspace
spelling	oai:doaj.org-article:70c84502ebb94488990d301031f7915f2021-12-02T16:49:38ZLive-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation10.1038/s41467-018-04455-72041-1723https://doaj.org/article/70c84502ebb94488990d301031f7915f2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04455-7https://doaj.org/toc/2041-1723Diffuse intrinsic pontine gliomas exhibit a characteristic mutation of lysine 27 to methionine (K27M) in genes encoding histone H3.3. Here the authors show that the H3.3K27M mutation imposes a specific pattern of H3.3K27 methylation by altering the target search dynamics of PcG proteins.Roubina TatavosianHuy Nguyen DucThao Ngoc HuynhDong FangBenjamin SchmittXiaodong ShiYiming DengChristopher PhielTingting YaoZhiguo ZhangHaobin WangXiaojun RenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roubina Tatavosian Huy Nguyen Duc Thao Ngoc Huynh Dong Fang Benjamin Schmitt Xiaodong Shi Yiming Deng Christopher Phiel Tingting Yao Zhiguo Zhang Haobin Wang Xiaojun Ren Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation
description	Diffuse intrinsic pontine gliomas exhibit a characteristic mutation of lysine 27 to methionine (K27M) in genes encoding histone H3.3. Here the authors show that the H3.3K27M mutation imposes a specific pattern of H3.3K27 methylation by altering the target search dynamics of PcG proteins.
format	article
author	Roubina Tatavosian Huy Nguyen Duc Thao Ngoc Huynh Dong Fang Benjamin Schmitt Xiaodong Shi Yiming Deng Christopher Phiel Tingting Yao Zhiguo Zhang Haobin Wang Xiaojun Ren
author_facet	Roubina Tatavosian Huy Nguyen Duc Thao Ngoc Huynh Dong Fang Benjamin Schmitt Xiaodong Shi Yiming Deng Christopher Phiel Tingting Yao Zhiguo Zhang Haobin Wang Xiaojun Ren
author_sort	Roubina Tatavosian
title	Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation
title_short	Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation
title_full	Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation
title_fullStr	Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation
title_full_unstemmed	Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation
title_sort	live-cell single-molecule dynamics of pcg proteins imposed by the dipg h3.3k27m mutation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/70c84502ebb94488990d301031f7915f
work_keys_str_mv	AT roubinatatavosian livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation AT huynguyenduc livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation AT thaongochuynh livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation AT dongfang livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation AT benjaminschmitt livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation AT xiaodongshi livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation AT yimingdeng livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation AT christopherphiel livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation AT tingtingyao livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation AT zhiguozhang livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation AT haobinwang livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation AT xiaojunren livecellsinglemoleculedynamicsofpcgproteinsimposedbythedipgh33k27mmutation
_version_	1718383284571865088

Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation

Ejemplares similares