Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds

Isodon diterpenoids, promising anti-cancer agents found in certain tropical plants, are difficult to obtain. Here, the authors developed a synthetic strategy to synthesise several different members of this group, including neolaxiflorin L which emerged from this study as a promising drug candidate.

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Autores principales:	Lizhi Zhu, Wenjing Ma, Mengxun Zhang, Magnolia Muk-Lan Lee, Wing-Yan Wong, Brandon Dow Chan, Qianqian Yang, Wing-Tak Wong, William Chi-Shing Tai, Chi-Sing Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70c95709ae4c4540a0c3d8a5a744cc4d
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spelling	oai:doaj.org-article:70c95709ae4c4540a0c3d8a5a744cc4d2021-12-02T14:40:10ZScalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds10.1038/s41467-018-03546-92041-1723https://doaj.org/article/70c95709ae4c4540a0c3d8a5a744cc4d2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03546-9https://doaj.org/toc/2041-1723Isodon diterpenoids, promising anti-cancer agents found in certain tropical plants, are difficult to obtain. Here, the authors developed a synthetic strategy to synthesise several different members of this group, including neolaxiflorin L which emerged from this study as a promising drug candidate.Lizhi ZhuWenjing MaMengxun ZhangMagnolia Muk-Lan LeeWing-Yan WongBrandon Dow ChanQianqian YangWing-Tak WongWilliam Chi-Shing TaiChi-Sing LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lizhi Zhu Wenjing Ma Mengxun Zhang Magnolia Muk-Lan Lee Wing-Yan Wong Brandon Dow Chan Qianqian Yang Wing-Tak Wong William Chi-Shing Tai Chi-Sing Lee Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds
description	Isodon diterpenoids, promising anti-cancer agents found in certain tropical plants, are difficult to obtain. Here, the authors developed a synthetic strategy to synthesise several different members of this group, including neolaxiflorin L which emerged from this study as a promising drug candidate.
format	article
author	Lizhi Zhu Wenjing Ma Mengxun Zhang Magnolia Muk-Lan Lee Wing-Yan Wong Brandon Dow Chan Qianqian Yang Wing-Tak Wong William Chi-Shing Tai Chi-Sing Lee
author_facet	Lizhi Zhu Wenjing Ma Mengxun Zhang Magnolia Muk-Lan Lee Wing-Yan Wong Brandon Dow Chan Qianqian Yang Wing-Tak Wong William Chi-Shing Tai Chi-Sing Lee
author_sort	Lizhi Zhu
title	Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds
title_short	Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds
title_full	Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds
title_fullStr	Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds
title_full_unstemmed	Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds
title_sort	scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/70c95709ae4c4540a0c3d8a5a744cc4d
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Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds

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