TGF-β-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice

TGF-β-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice

Abstract Hepatocyte death, as well as the following inflammatory and fibrogenic signaling cascades, is the key trigger of liver fibrosis. Here, we isolated hepatocytes from CCl4-induced fibrotic liver and found that hepatocyte lincRNA-p21 significantly increased during liver fibrosis. The increase o...

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Autores principales: Xiaolong Tu, Yuanyuan Zhang, Xiuxiu Zheng, Jia Deng, Huanan Li, Zhiqian Kang, Zhipeng Cao, Zhen Huang, Zhi Ding, Lei Dong, Jiangning Chen, Yuhui Zang, Junfeng Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/70ce8021694d4e498c58905a70720ed8
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