Confocal laser scanning microscopy for the diagnosis of dysplastic nevus of the skin

In cases of complex differential diagnosis of benign melanocytic neoplasms, dysplastic nevi and skin melanoma, clinical visual inspection and superficial dermatoscopy do not always allow an accurate diagnosis, which is especially important in cases of suspected skin melanoma. In recent years, the me...

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Autores principales:	A. V. Sokolova, N. P. Malishevskaya
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	dysplastic nevus skin melanoma melanoma diagnosis confocal laser scanning microscopy Science Q
Acceso en línea:	https://doaj.org/article/70cecb981ae84769b580fed64dae0602
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id	oai:doaj.org-article:70cecb981ae84769b580fed64dae0602
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spelling	oai:doaj.org-article:70cecb981ae84769b580fed64dae06022021-11-23T06:14:40ZConfocal laser scanning microscopy for the diagnosis of dysplastic nevus of the skin2541-94202587-959610.29413/ABS.2018-3.2.9https://doaj.org/article/70cecb981ae84769b580fed64dae06022018-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/559https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596In cases of complex differential diagnosis of benign melanocytic neoplasms, dysplastic nevi and skin melanoma, clinical visual inspection and superficial dermatoscopy do not always allow an accurate diagnosis, which is especially important in cases of suspected skin melanoma. In recent years, the method of confocal microscopy has been used for noninvasive skin examination. In the present study, 15 patients with suspected melanoma skin were examined by the method of confocal laser scanning microscopy in cases of complex differential diagnosis (18 melanocytic neoplasms in total). In 8 cases of melanocytic neoplasms, dysplastic nevus was diagnosed. In 10 patients, skin melanoma was diagnosed, which was subsequently confirmed by histological examination of the material obtained after surgical excision. Conducting a comparative analysis of the total incidence of signs of dysplastic nevus showed the unreliability of the confocal microscopy method for differential diagnosis of dysplastic nevus and skin melanoma with orientation only on confocal-microscopic signs of dysplastic nevus. For differential diagnosis of skin melanoma, the presence of the main criteria of malignancy is sufficient: cellular atypia at the site of the dermo-epidermal junction and the disturbance of the papillary architecture of the basal layer. At detection of at least one of these criteria, a diagnosis of skin melanoma was made, which in all cases was confirmed by the results of histological examination. The inclusion of confocal microscopy in the diagnostic algorithm for examining patients with melanocytic skin lesions suspected of melanoma makes it possible to improve the diagnosis of melanoma in the early stages, since the greatest difficulty is the differential diagnosis of dysplastic nevus with early melanoma.A. V. SokolovaN. P. MalishevskayaScientific Сentre for Family Health and Human Reproduction Problemsarticledysplastic nevusskin melanomamelanoma diagnosisconfocal laser scanning microscopyScienceQRUActa Biomedica Scientifica, Vol 3, Iss 2, Pp 50-55 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	dysplastic nevus skin melanoma melanoma diagnosis confocal laser scanning microscopy Science Q
spellingShingle	dysplastic nevus skin melanoma melanoma diagnosis confocal laser scanning microscopy Science Q A. V. Sokolova N. P. Malishevskaya Confocal laser scanning microscopy for the diagnosis of dysplastic nevus of the skin
description	In cases of complex differential diagnosis of benign melanocytic neoplasms, dysplastic nevi and skin melanoma, clinical visual inspection and superficial dermatoscopy do not always allow an accurate diagnosis, which is especially important in cases of suspected skin melanoma. In recent years, the method of confocal microscopy has been used for noninvasive skin examination. In the present study, 15 patients with suspected melanoma skin were examined by the method of confocal laser scanning microscopy in cases of complex differential diagnosis (18 melanocytic neoplasms in total). In 8 cases of melanocytic neoplasms, dysplastic nevus was diagnosed. In 10 patients, skin melanoma was diagnosed, which was subsequently confirmed by histological examination of the material obtained after surgical excision. Conducting a comparative analysis of the total incidence of signs of dysplastic nevus showed the unreliability of the confocal microscopy method for differential diagnosis of dysplastic nevus and skin melanoma with orientation only on confocal-microscopic signs of dysplastic nevus. For differential diagnosis of skin melanoma, the presence of the main criteria of malignancy is sufficient: cellular atypia at the site of the dermo-epidermal junction and the disturbance of the papillary architecture of the basal layer. At detection of at least one of these criteria, a diagnosis of skin melanoma was made, which in all cases was confirmed by the results of histological examination. The inclusion of confocal microscopy in the diagnostic algorithm for examining patients with melanocytic skin lesions suspected of melanoma makes it possible to improve the diagnosis of melanoma in the early stages, since the greatest difficulty is the differential diagnosis of dysplastic nevus with early melanoma.
format	article
author	A. V. Sokolova N. P. Malishevskaya
author_facet	A. V. Sokolova N. P. Malishevskaya
author_sort	A. V. Sokolova
title	Confocal laser scanning microscopy for the diagnosis of dysplastic nevus of the skin
title_short	Confocal laser scanning microscopy for the diagnosis of dysplastic nevus of the skin
title_full	Confocal laser scanning microscopy for the diagnosis of dysplastic nevus of the skin
title_fullStr	Confocal laser scanning microscopy for the diagnosis of dysplastic nevus of the skin
title_full_unstemmed	Confocal laser scanning microscopy for the diagnosis of dysplastic nevus of the skin
title_sort	confocal laser scanning microscopy for the diagnosis of dysplastic nevus of the skin
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/70cecb981ae84769b580fed64dae0602
work_keys_str_mv	AT avsokolova confocallaserscanningmicroscopyforthediagnosisofdysplasticnevusoftheskin AT npmalishevskaya confocallaserscanningmicroscopyforthediagnosisofdysplasticnevusoftheskin
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Confocal laser scanning microscopy for the diagnosis of dysplastic nevus of the skin

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