SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells

SAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. describe an additional SUMOylation at residue K595, w...

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Autores principales:	Charlotte Martinat, Arthur Cormier, Joëlle Tobaly-Tapiero, Noé Palmic, Nicoletta Casartelli, Bijan Mahboubi, Si’Ana A. Coggins, Julian Buchrieser, Mirjana Persaud, Felipe Diaz-Griffero, Lucile Espert, Guillaume Bossis, Pascale Lesage, Olivier Schwartz, Baek Kim, Florence Margottin-Goguet, Ali Saïb, Alessia Zamborlini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70d02ba8c29446d69d93dada293f5c11
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spelling	oai:doaj.org-article:70d02ba8c29446d69d93dada293f5c112021-12-02T16:14:24ZSUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells10.1038/s41467-021-24802-52041-1723https://doaj.org/article/70d02ba8c29446d69d93dada293f5c112021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24802-5https://doaj.org/toc/2041-1723SAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. describe an additional SUMOylation at residue K595, which promotes the dNTPase-independent restriction activity.Charlotte MartinatArthur CormierJoëlle Tobaly-TapieroNoé PalmicNicoletta CasartelliBijan MahboubiSi’Ana A. CogginsJulian BuchrieserMirjana PersaudFelipe Diaz-GrifferoLucile EspertGuillaume BossisPascale LesageOlivier SchwartzBaek KimFlorence Margottin-GoguetAli SaïbAlessia ZamborliniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Charlotte Martinat Arthur Cormier Joëlle Tobaly-Tapiero Noé Palmic Nicoletta Casartelli Bijan Mahboubi Si’Ana A. Coggins Julian Buchrieser Mirjana Persaud Felipe Diaz-Griffero Lucile Espert Guillaume Bossis Pascale Lesage Olivier Schwartz Baek Kim Florence Margottin-Goguet Ali Saïb Alessia Zamborlini SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
description	SAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. describe an additional SUMOylation at residue K595, which promotes the dNTPase-independent restriction activity.
format	article
author	Charlotte Martinat Arthur Cormier Joëlle Tobaly-Tapiero Noé Palmic Nicoletta Casartelli Bijan Mahboubi Si’Ana A. Coggins Julian Buchrieser Mirjana Persaud Felipe Diaz-Griffero Lucile Espert Guillaume Bossis Pascale Lesage Olivier Schwartz Baek Kim Florence Margottin-Goguet Ali Saïb Alessia Zamborlini
author_facet	Charlotte Martinat Arthur Cormier Joëlle Tobaly-Tapiero Noé Palmic Nicoletta Casartelli Bijan Mahboubi Si’Ana A. Coggins Julian Buchrieser Mirjana Persaud Felipe Diaz-Griffero Lucile Espert Guillaume Bossis Pascale Lesage Olivier Schwartz Baek Kim Florence Margottin-Goguet Ali Saïb Alessia Zamborlini
author_sort	Charlotte Martinat
title	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
title_short	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
title_full	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
title_fullStr	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
title_full_unstemmed	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
title_sort	sumoylation of samhd1 at lysine 595 is required for hiv-1 restriction in non-cycling cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/70d02ba8c29446d69d93dada293f5c11
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SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells

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