C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
Alpha-synuclein is associated with neuronal dysfunction in Parkinson’s disease. This study shows that alpha-synuclein interacts with neuronal synaptic vesicles in a calcium-dependent fashion, and this interaction is important for synaptic vesicle clustering.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/70d12e9421354902991a3d31fd154a54 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:70d12e9421354902991a3d31fd154a54 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:70d12e9421354902991a3d31fd154a542021-12-02T16:56:37ZC-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction10.1038/s41467-018-03111-42041-1723https://doaj.org/article/70d12e9421354902991a3d31fd154a542018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03111-4https://doaj.org/toc/2041-1723Alpha-synuclein is associated with neuronal dysfunction in Parkinson’s disease. This study shows that alpha-synuclein interacts with neuronal synaptic vesicles in a calcium-dependent fashion, and this interaction is important for synaptic vesicle clustering.Janin LautenschlägerAmberley D. StephensGiuliana FuscoFlorian StröhlNathan CurryMaria ZacharopoulouClaire H. MichelRomain LaineNadezhda NespovitayaMarcus FanthamDorothea PinotsiWagner ZagoPaul FraserAnurag TandonPeter St George-HyslopEric ReesJonathan J. PhillipsAlfonso De SimoneClemens F. KaminskiGabriele S. Kaminski SchierleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Janin Lautenschläger Amberley D. Stephens Giuliana Fusco Florian Ströhl Nathan Curry Maria Zacharopoulou Claire H. Michel Romain Laine Nadezhda Nespovitaya Marcus Fantham Dorothea Pinotsi Wagner Zago Paul Fraser Anurag Tandon Peter St George-Hyslop Eric Rees Jonathan J. Phillips Alfonso De Simone Clemens F. Kaminski Gabriele S. Kaminski Schierle C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction |
| description |
Alpha-synuclein is associated with neuronal dysfunction in Parkinson’s disease. This study shows that alpha-synuclein interacts with neuronal synaptic vesicles in a calcium-dependent fashion, and this interaction is important for synaptic vesicle clustering. |
| format |
article |
| author |
Janin Lautenschläger Amberley D. Stephens Giuliana Fusco Florian Ströhl Nathan Curry Maria Zacharopoulou Claire H. Michel Romain Laine Nadezhda Nespovitaya Marcus Fantham Dorothea Pinotsi Wagner Zago Paul Fraser Anurag Tandon Peter St George-Hyslop Eric Rees Jonathan J. Phillips Alfonso De Simone Clemens F. Kaminski Gabriele S. Kaminski Schierle |
| author_facet |
Janin Lautenschläger Amberley D. Stephens Giuliana Fusco Florian Ströhl Nathan Curry Maria Zacharopoulou Claire H. Michel Romain Laine Nadezhda Nespovitaya Marcus Fantham Dorothea Pinotsi Wagner Zago Paul Fraser Anurag Tandon Peter St George-Hyslop Eric Rees Jonathan J. Phillips Alfonso De Simone Clemens F. Kaminski Gabriele S. Kaminski Schierle |
| author_sort |
Janin Lautenschläger |
| title |
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction |
| title_short |
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction |
| title_full |
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction |
| title_fullStr |
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction |
| title_full_unstemmed |
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction |
| title_sort |
c-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/70d12e9421354902991a3d31fd154a54 |
| work_keys_str_mv |
AT janinlautenschlager cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT amberleydstephens cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT giulianafusco cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT florianstrohl cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT nathancurry cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT mariazacharopoulou cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT clairehmichel cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT romainlaine cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT nadezhdanespovitaya cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT marcusfantham cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT dorotheapinotsi cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT wagnerzago cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT paulfraser cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT anuragtandon cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT peterstgeorgehyslop cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT ericrees cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT jonathanjphillips cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT alfonsodesimone cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT clemensfkaminski cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction AT gabrieleskaminskischierle cterminalcalciumbindingofasynucleinmodulatessynapticvesicleinteraction |
| _version_ |
1718382804988854272 |