Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury

Neuroprotective effects of Sigma-1 receptor (S1R) ligands have been observed in multiple animal models of neurodegenerative diseases. Traumatic brain injury (TBI)-related neurodegeneration can induce long-lasting physical, cognitive, and behavioral disabilities. The aim of our study was to evaluate...

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Autores principales:	Gundega Stelfa, Edijs Vavers, Baiba Svalbe, Rinalds Serzants, Anna Miteniece, Lasma Lauberte, Solveiga Grinberga, Baiba Gukalova, Maija Dambrova, Liga Zvejniece
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sigma-1 receptor traumatic brain injury lateral fluid percussion injury neurobehavior cerebellum astrocytes Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/70d253feb31247a8af31dba787ef2f8e
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spelling	oai:doaj.org-article:70d253feb31247a8af31dba787ef2f8e2021-11-11T17:05:29ZReduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury10.3390/ijms2221116111422-00671661-6596https://doaj.org/article/70d253feb31247a8af31dba787ef2f8e2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11611https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Neuroprotective effects of Sigma-1 receptor (S1R) ligands have been observed in multiple animal models of neurodegenerative diseases. Traumatic brain injury (TBI)-related neurodegeneration can induce long-lasting physical, cognitive, and behavioral disabilities. The aim of our study was to evaluate the role of S1R in the development of neurological deficits after TBI. Adult male wild-type CD-1 (WT) and S1R knockout (S1R-/-) mice were subjected to lateral fluid percussion injury, and behavioral and histological outcomes were assessed for up to 12 months postinjury. Neurological deficits and motor coordination impairment were less pronounced in S1R-/- mice with TBI than in WT mice with TBI 24 h after injury. TBI-induced short-term memory impairments were present in WT but not S1R-/- mice 7 months after injury. Compared to WT animals, S1R-/- mice exhibited better motor coordination and less pronounced despair behavior for up to 12 months postinjury. TBI induced astrocyte activation in the cortex of WT but not S1R-/- mice. S1R-/- mice presented a significantly reduced GFAP expression in Bergmann glial cells in the molecular layer of the cerebellum compared to WT mice. Our findings suggest that S1R deficiency reduces TBI-induced motor coordination impairments by reducing GFAP expression in Bergmann glial cells in the cerebellum.Gundega StelfaEdijs VaversBaiba SvalbeRinalds SerzantsAnna MitenieceLasma LauberteSolveiga GrinbergaBaiba GukalovaMaija DambrovaLiga ZvejnieceMDPI AGarticlesigma-1 receptortraumatic brain injurylateral fluid percussion injuryneurobehaviorcerebellumastrocytesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11611, p 11611 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sigma-1 receptor traumatic brain injury lateral fluid percussion injury neurobehavior cerebellum astrocytes Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	sigma-1 receptor traumatic brain injury lateral fluid percussion injury neurobehavior cerebellum astrocytes Biology (General) QH301-705.5 Chemistry QD1-999 Gundega Stelfa Edijs Vavers Baiba Svalbe Rinalds Serzants Anna Miteniece Lasma Lauberte Solveiga Grinberga Baiba Gukalova Maija Dambrova Liga Zvejniece Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury
description	Neuroprotective effects of Sigma-1 receptor (S1R) ligands have been observed in multiple animal models of neurodegenerative diseases. Traumatic brain injury (TBI)-related neurodegeneration can induce long-lasting physical, cognitive, and behavioral disabilities. The aim of our study was to evaluate the role of S1R in the development of neurological deficits after TBI. Adult male wild-type CD-1 (WT) and S1R knockout (S1R-/-) mice were subjected to lateral fluid percussion injury, and behavioral and histological outcomes were assessed for up to 12 months postinjury. Neurological deficits and motor coordination impairment were less pronounced in S1R-/- mice with TBI than in WT mice with TBI 24 h after injury. TBI-induced short-term memory impairments were present in WT but not S1R-/- mice 7 months after injury. Compared to WT animals, S1R-/- mice exhibited better motor coordination and less pronounced despair behavior for up to 12 months postinjury. TBI induced astrocyte activation in the cortex of WT but not S1R-/- mice. S1R-/- mice presented a significantly reduced GFAP expression in Bergmann glial cells in the molecular layer of the cerebellum compared to WT mice. Our findings suggest that S1R deficiency reduces TBI-induced motor coordination impairments by reducing GFAP expression in Bergmann glial cells in the cerebellum.
format	article
author	Gundega Stelfa Edijs Vavers Baiba Svalbe Rinalds Serzants Anna Miteniece Lasma Lauberte Solveiga Grinberga Baiba Gukalova Maija Dambrova Liga Zvejniece
author_facet	Gundega Stelfa Edijs Vavers Baiba Svalbe Rinalds Serzants Anna Miteniece Lasma Lauberte Solveiga Grinberga Baiba Gukalova Maija Dambrova Liga Zvejniece
author_sort	Gundega Stelfa
title	Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury
title_short	Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury
title_full	Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury
title_fullStr	Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury
title_full_unstemmed	Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury
title_sort	reduced gfap expression in bergmann glial cells in the cerebellum of sigma-1 receptor knockout mice determines the neurobehavioral outcomes after traumatic brain injury
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/70d253feb31247a8af31dba787ef2f8e
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Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury

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