Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury

Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury

Neuroprotective effects of Sigma-1 receptor (S1R) ligands have been observed in multiple animal models of neurodegenerative diseases. Traumatic brain injury (TBI)-related neurodegeneration can induce long-lasting physical, cognitive, and behavioral disabilities. The aim of our study was to evaluate...

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Bibliographic Details
Main Authors: Gundega Stelfa, Edijs Vavers, Baiba Svalbe, Rinalds Serzants, Anna Miteniece, Lasma Lauberte, Solveiga Grinberga, Baiba Gukalova, Maija Dambrova, Liga Zvejniece
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
sigma-1 receptor
traumatic brain injury
lateral fluid percussion injury
neurobehavior
cerebellum
astrocytes
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/70d253feb31247a8af31dba787ef2f8e
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https://doaj.org/article/70d253feb31247a8af31dba787ef2f8e

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