Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook

Preeya K Gupta,1 Laura M Periman,2 Edward Lain,3 Eric Donnenfeld,4 John Hovanesian,5 Terry Kim,6 William Trattler,7 Elizabeth Yeu,8 Edward Holland9 1Triangle Eye Consultants, Durham, NC, USA; 2Periman Eye Institute, Seattle, WA, USA; 3Sanova Dermatology, Pflugerville, TX, USA; 4Ophthalmic Consultant...

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Autores principales:	Gupta PK, Periman LM, Lain E, Donnenfeld E, Hovanesian J, Kim T, Trattler W, Yeu E, Holland E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	meibomian gland disease mgd hyperkeratinization Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/70d6a59e455c4ca397bcb6b2406ab72e
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spelling	oai:doaj.org-article:70d6a59e455c4ca397bcb6b2406ab72e2021-12-02T18:11:23ZMeibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook1177-5483https://doaj.org/article/70d6a59e455c4ca397bcb6b2406ab72e2021-11-01T00:00:00Zhttps://www.dovepress.com/meibomian-gland-dysfunction-a-dermatological-perspective-on-pathogenes-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Preeya K Gupta,1 Laura M Periman,2 Edward Lain,3 Eric Donnenfeld,4 John Hovanesian,5 Terry Kim,6 William Trattler,7 Elizabeth Yeu,8 Edward Holland9 1Triangle Eye Consultants, Durham, NC, USA; 2Periman Eye Institute, Seattle, WA, USA; 3Sanova Dermatology, Pflugerville, TX, USA; 4Ophthalmic Consultants of Long Island, Garden City, NJ, USA; 5Harvard Eye Associates, Laguna Hills, CA, USA; 6Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA; 7Center for Excellence in Eye Care, Miami, FL, USA; 8Virginia Eye Consultants, Norfolk, VA, USA; 9Cincinnati Eye Institute, Edgewood, KY, USACorrespondence: Preeya K Gupta Email preeyakgupta@gmail.comAbstract: Meibomian glands are modified oil-producing glands that produce meibum and can become dysfunctional and negatively affect the lipid layer in the tear film, resulting in ocular surface diseases such as evaporative dry eye. Abnormal keratin production and aggregation at the meibomian gland orifice has been implicated in the pathogenesis of meibomian gland dysfunction (MGD). Current treatments largely ignore the role of keratin proteins. This review paper synthesizes various publications on hyperkeratinization and its role in MGD pathogenesis and proposes a novel treatment strategy for MGD that involves the use of keratolytic agents commonly used in dermatological treatments.Keywords: meibomian gland disease, MGD, hyperkeratinizationGupta PKPeriman LMLain EDonnenfeld EHovanesian JKim TTrattler WYeu EHolland EDove Medical Pressarticlemeibomian gland diseasemgdhyperkeratinizationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 4399-4404 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	meibomian gland disease mgd hyperkeratinization Ophthalmology RE1-994
spellingShingle	meibomian gland disease mgd hyperkeratinization Ophthalmology RE1-994 Gupta PK Periman LM Lain E Donnenfeld E Hovanesian J Kim T Trattler W Yeu E Holland E Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook
description	Preeya K Gupta,1 Laura M Periman,2 Edward Lain,3 Eric Donnenfeld,4 John Hovanesian,5 Terry Kim,6 William Trattler,7 Elizabeth Yeu,8 Edward Holland9 1Triangle Eye Consultants, Durham, NC, USA; 2Periman Eye Institute, Seattle, WA, USA; 3Sanova Dermatology, Pflugerville, TX, USA; 4Ophthalmic Consultants of Long Island, Garden City, NJ, USA; 5Harvard Eye Associates, Laguna Hills, CA, USA; 6Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA; 7Center for Excellence in Eye Care, Miami, FL, USA; 8Virginia Eye Consultants, Norfolk, VA, USA; 9Cincinnati Eye Institute, Edgewood, KY, USACorrespondence: Preeya K Gupta Email preeyakgupta@gmail.comAbstract: Meibomian glands are modified oil-producing glands that produce meibum and can become dysfunctional and negatively affect the lipid layer in the tear film, resulting in ocular surface diseases such as evaporative dry eye. Abnormal keratin production and aggregation at the meibomian gland orifice has been implicated in the pathogenesis of meibomian gland dysfunction (MGD). Current treatments largely ignore the role of keratin proteins. This review paper synthesizes various publications on hyperkeratinization and its role in MGD pathogenesis and proposes a novel treatment strategy for MGD that involves the use of keratolytic agents commonly used in dermatological treatments.Keywords: meibomian gland disease, MGD, hyperkeratinization
format	article
author	Gupta PK Periman LM Lain E Donnenfeld E Hovanesian J Kim T Trattler W Yeu E Holland E
author_facet	Gupta PK Periman LM Lain E Donnenfeld E Hovanesian J Kim T Trattler W Yeu E Holland E
author_sort	Gupta PK
title	Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook
title_short	Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook
title_full	Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook
title_fullStr	Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook
title_full_unstemmed	Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook
title_sort	meibomian gland dysfunction: a dermatological perspective on pathogenesis and treatment outlook
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/70d6a59e455c4ca397bcb6b2406ab72e
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Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook

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