Brain structure and function changes in ulcerative colitis

As the importance of the brain-gut axis in the pathobiology of inflammatory bowel disease continues to evolve, a greater understanding of brain structure and brain functional connectivity (FC) in diseases such as ulcerative colitis (UC) are necessary. In this magnetic resonance imaging (MRI) study,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jennifer Kornelsen, Kelcie Witges, Jennifer Labus, Emeran A. Mayer, Charles N. Bernstein
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Ulcerative colitis (UC) Inflammatory bowel disease (IBD) Resting state networks (RSN) Grey matter volume Functional connectivity (FC) Functional magnetic resonance imaging (fMRI) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/70d8f07577f84115b021fc2179bb67c0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:70d8f07577f84115b021fc2179bb67c0
record_format	dspace
spelling	oai:doaj.org-article:70d8f07577f84115b021fc2179bb67c02021-11-16T04:11:37ZBrain structure and function changes in ulcerative colitis2666-956010.1016/j.ynirp.2021.100064https://doaj.org/article/70d8f07577f84115b021fc2179bb67c02021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666956021000623https://doaj.org/toc/2666-9560As the importance of the brain-gut axis in the pathobiology of inflammatory bowel disease continues to evolve, a greater understanding of brain structure and brain functional connectivity (FC) in diseases such as ulcerative colitis (UC) are necessary. In this magnetic resonance imaging (MRI) study, we investigated differences in brain structure and in FC of brain regions in 76 participants with UC and 74 healthy controls (HC). Voxel based morphometry analysis indicated greater grey matter volume in multiple brain regions in UC as compared to HC. Differences in FC between groups were identified in the cerebellar, default mode, visual, and dorsal attention networks. FC differed by sex for the visual and dorsal attention networks. These differences provide evidence that the brain-gut axis is altered in UC and warrant further investigation to determine if they help direct the evolution of UC or if they evolve in response to the presence of UC.Jennifer KornelsenKelcie WitgesJennifer LabusEmeran A. MayerCharles N. BernsteinElsevierarticleUlcerative colitis (UC)Inflammatory bowel disease (IBD)Resting state networks (RSN)Grey matter volumeFunctional connectivity (FC)Functional magnetic resonance imaging (fMRI)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroimage: Reports, Vol 1, Iss 4, Pp 100064- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ulcerative colitis (UC) Inflammatory bowel disease (IBD) Resting state networks (RSN) Grey matter volume Functional connectivity (FC) Functional magnetic resonance imaging (fMRI) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Ulcerative colitis (UC) Inflammatory bowel disease (IBD) Resting state networks (RSN) Grey matter volume Functional connectivity (FC) Functional magnetic resonance imaging (fMRI) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jennifer Kornelsen Kelcie Witges Jennifer Labus Emeran A. Mayer Charles N. Bernstein Brain structure and function changes in ulcerative colitis
description	As the importance of the brain-gut axis in the pathobiology of inflammatory bowel disease continues to evolve, a greater understanding of brain structure and brain functional connectivity (FC) in diseases such as ulcerative colitis (UC) are necessary. In this magnetic resonance imaging (MRI) study, we investigated differences in brain structure and in FC of brain regions in 76 participants with UC and 74 healthy controls (HC). Voxel based morphometry analysis indicated greater grey matter volume in multiple brain regions in UC as compared to HC. Differences in FC between groups were identified in the cerebellar, default mode, visual, and dorsal attention networks. FC differed by sex for the visual and dorsal attention networks. These differences provide evidence that the brain-gut axis is altered in UC and warrant further investigation to determine if they help direct the evolution of UC or if they evolve in response to the presence of UC.
format	article
author	Jennifer Kornelsen Kelcie Witges Jennifer Labus Emeran A. Mayer Charles N. Bernstein
author_facet	Jennifer Kornelsen Kelcie Witges Jennifer Labus Emeran A. Mayer Charles N. Bernstein
author_sort	Jennifer Kornelsen
title	Brain structure and function changes in ulcerative colitis
title_short	Brain structure and function changes in ulcerative colitis
title_full	Brain structure and function changes in ulcerative colitis
title_fullStr	Brain structure and function changes in ulcerative colitis
title_full_unstemmed	Brain structure and function changes in ulcerative colitis
title_sort	brain structure and function changes in ulcerative colitis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/70d8f07577f84115b021fc2179bb67c0
work_keys_str_mv	AT jenniferkornelsen brainstructureandfunctionchangesinulcerativecolitis AT kelciewitges brainstructureandfunctionchangesinulcerativecolitis AT jenniferlabus brainstructureandfunctionchangesinulcerativecolitis AT emeranamayer brainstructureandfunctionchangesinulcerativecolitis AT charlesnbernstein brainstructureandfunctionchangesinulcerativecolitis
_version_	1718426730584080384

Brain structure and function changes in ulcerative colitis

Ejemplares similares