The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A

Incomplete biological concepts in lymphoid neoplasms still dictate to a large extent the limited availability of efficient targeted treatments, which entertains the mostly unsatisfactory clinical outcomes. Aberrant expression of the embryonal and lymphatic TCL1 family of oncogenes, i.e., the paradig...

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Autores principales:	Johanna Stachelscheid, Qu Jiang, Marco Herling
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	TCL1 oncogenes kinase signaling lymphoma T-PLL CLL BPDCN Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/70ddfc46c0374e148d64c6eafdab4daf
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spelling	oai:doaj.org-article:70ddfc46c0374e148d64c6eafdab4daf2021-11-11T15:33:30ZThe Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A10.3390/cancers132154552072-6694https://doaj.org/article/70ddfc46c0374e148d64c6eafdab4daf2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5455https://doaj.org/toc/2072-6694Incomplete biological concepts in lymphoid neoplasms still dictate to a large extent the limited availability of efficient targeted treatments, which entertains the mostly unsatisfactory clinical outcomes. Aberrant expression of the embryonal and lymphatic TCL1 family of oncogenes, i.e., the paradigmatic <i>TCL1A</i>, but also <i>TML1</i> or <i>MTCP1</i>, is causally implicated in T- and B-lymphocyte transformation. TCL1A also carries prognostic information in these particular T-cell and B-cell tumors. More recently, the <i>TCL1A</i> oncogene has been observed also in epithelial tumors as part of oncofetal stemness signatures. Although the concepts on the modes of TCL1A dysregulation in lymphatic neoplasms and solid tumors are still incomplete, there are recent advances in defining the mechanisms of its (de)regulation. This review presents a comprehensive overview of TCL1A expression in tumors and the current understanding of its (dys)regulation via genomic aberrations, epigenetic modifications, or deregulation of TCL1A-targeting micro RNAs. We also summarize triggers that act through such transcriptional and translational regulation, i.e., altered signals by the tumor microenvironment. A refined mechanistic understanding of these modes of dysregulations together with improved concepts of TCL1A-associated malignant transformation can benefit future approaches to specifically interfere in TCL1A-initiated or -driven tumorigenesis.Johanna StachelscheidQu JiangMarco HerlingMDPI AGarticleTCL1 oncogeneskinase signalinglymphomaT-PLLCLLBPDCNNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5455, p 5455 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TCL1 oncogenes kinase signaling lymphoma T-PLL CLL BPDCN Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	TCL1 oncogenes kinase signaling lymphoma T-PLL CLL BPDCN Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Johanna Stachelscheid Qu Jiang Marco Herling The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A
description	Incomplete biological concepts in lymphoid neoplasms still dictate to a large extent the limited availability of efficient targeted treatments, which entertains the mostly unsatisfactory clinical outcomes. Aberrant expression of the embryonal and lymphatic TCL1 family of oncogenes, i.e., the paradigmatic <i>TCL1A</i>, but also <i>TML1</i> or <i>MTCP1</i>, is causally implicated in T- and B-lymphocyte transformation. TCL1A also carries prognostic information in these particular T-cell and B-cell tumors. More recently, the <i>TCL1A</i> oncogene has been observed also in epithelial tumors as part of oncofetal stemness signatures. Although the concepts on the modes of TCL1A dysregulation in lymphatic neoplasms and solid tumors are still incomplete, there are recent advances in defining the mechanisms of its (de)regulation. This review presents a comprehensive overview of TCL1A expression in tumors and the current understanding of its (dys)regulation via genomic aberrations, epigenetic modifications, or deregulation of TCL1A-targeting micro RNAs. We also summarize triggers that act through such transcriptional and translational regulation, i.e., altered signals by the tumor microenvironment. A refined mechanistic understanding of these modes of dysregulations together with improved concepts of TCL1A-associated malignant transformation can benefit future approaches to specifically interfere in TCL1A-initiated or -driven tumorigenesis.
format	article
author	Johanna Stachelscheid Qu Jiang Marco Herling
author_facet	Johanna Stachelscheid Qu Jiang Marco Herling
author_sort	Johanna Stachelscheid
title	The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A
title_short	The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A
title_full	The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A
title_fullStr	The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A
title_full_unstemmed	The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A
title_sort	modes of dysregulation of the proto-oncogene t-cell leukemia/lymphoma 1a
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/70ddfc46c0374e148d64c6eafdab4daf
work_keys_str_mv	AT johannastachelscheid themodesofdysregulationoftheprotooncogenetcellleukemialymphoma1a AT qujiang themodesofdysregulationoftheprotooncogenetcellleukemialymphoma1a AT marcoherling themodesofdysregulationoftheprotooncogenetcellleukemialymphoma1a AT johannastachelscheid modesofdysregulationoftheprotooncogenetcellleukemialymphoma1a AT qujiang modesofdysregulationoftheprotooncogenetcellleukemialymphoma1a AT marcoherling modesofdysregulationoftheprotooncogenetcellleukemialymphoma1a
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The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A

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