Treadmill Exercise Ameliorates Short-term Memory Impairment by Suppressing Hippocampal Neuroinflammation in Poloxamer-407-Induced Hyperlipidemia Rats

Purpose Poloxamer-407 (P-407) is used to induce hyperlipidemia. Exercise is effective in improving arteriosclerosis and cognitive impairment. In this research, the effect of treadmill running on short-term memory in the P-407-treated hyperlipidemia rats was studied focusing on neuroinflammation. Met...

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Autores principales:	Sang-Seo Park, Tae-Woon Kim, Yun-Hee Sung, Yun-Jin Park, Myung-Ki Kim, Mal-Soon Shin
Formato:	article
Lenguaje:	EN
Publicado:	Korean Continence Society 2021
Materias:	hyperlipidemia treadmill exercise glial fibrillary acidic protein ionized calcium binding adaptor molecules 1 adhesion molecules proinflammatory cytokines Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/70e0e65459bd4f4e80df7850469ee80d
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spelling	oai:doaj.org-article:70e0e65459bd4f4e80df7850469ee80d2021-11-30T04:10:47ZTreadmill Exercise Ameliorates Short-term Memory Impairment by Suppressing Hippocampal Neuroinflammation in Poloxamer-407-Induced Hyperlipidemia Rats2093-47772093-693110.5213/inj.2142342.171https://doaj.org/article/70e0e65459bd4f4e80df7850469ee80d2021-11-01T00:00:00Zhttp://www.einj.org/upload/pdf/inj-2142342-171.pdfhttps://doaj.org/toc/2093-4777https://doaj.org/toc/2093-6931Purpose Poloxamer-407 (P-407) is used to induce hyperlipidemia. Exercise is effective in improving arteriosclerosis and cognitive impairment. In this research, the effect of treadmill running on short-term memory in the P-407-treated hyperlipidemia rats was studied focusing on neuroinflammation. Methods Rats were classified in normal group, normal and treadmill exercise group, P-407-treated group, and P-407-treated and treadmill exercise group. Hyperlipidemia rats were made by single intraperitoneal injection with P-407 (500 mg/kg). Treadmill exercise was conducted for 30 minutes once a day, 5 days per week during 28 days. Step-down avoidance task was done to measure short-term memory. Glial fibrillary acidic protein and ionized calcium binding adaptor molecule 1 were assessed by immunohistochemistry. Expression of adhesion molecules and proinflammatory cytokines was determined by western blot analysis. Results Treadmill exercise alleviated lipid profiles in the P-407-induced hyperlipidemia rats. Treadmill exercise improved short-term memory, inhibited reactive astrogliosis and microglia activation, and suppressed expression of adhesion molecules and proinflammatory cytokines in the hyperlipidemic rats. Conclusions Treadmill exercise exerts alleviating effect on memory deficits by inhibiting hippocampal neuroinflammation in the hyperlipidemia. The current results suggest that treadmill running serves as the treatment strategy for the cognitive dysfunction caused by hyperlipidemia.Sang-Seo ParkTae-Woon KimYun-Hee SungYun-Jin ParkMyung-Ki KimMal-Soon ShinKorean Continence Societyarticlehyperlipidemiatreadmill exerciseglial fibrillary acidic proteinionized calcium binding adaptor molecules 1adhesion moleculesproinflammatory cytokinesDiseases of the genitourinary system. UrologyRC870-923ENInternational Neurourology Journal, Vol 25, Iss Suppl 2, Pp S81-89 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperlipidemia treadmill exercise glial fibrillary acidic protein ionized calcium binding adaptor molecules 1 adhesion molecules proinflammatory cytokines Diseases of the genitourinary system. Urology RC870-923
spellingShingle	hyperlipidemia treadmill exercise glial fibrillary acidic protein ionized calcium binding adaptor molecules 1 adhesion molecules proinflammatory cytokines Diseases of the genitourinary system. Urology RC870-923 Sang-Seo Park Tae-Woon Kim Yun-Hee Sung Yun-Jin Park Myung-Ki Kim Mal-Soon Shin Treadmill Exercise Ameliorates Short-term Memory Impairment by Suppressing Hippocampal Neuroinflammation in Poloxamer-407-Induced Hyperlipidemia Rats
description	Purpose Poloxamer-407 (P-407) is used to induce hyperlipidemia. Exercise is effective in improving arteriosclerosis and cognitive impairment. In this research, the effect of treadmill running on short-term memory in the P-407-treated hyperlipidemia rats was studied focusing on neuroinflammation. Methods Rats were classified in normal group, normal and treadmill exercise group, P-407-treated group, and P-407-treated and treadmill exercise group. Hyperlipidemia rats were made by single intraperitoneal injection with P-407 (500 mg/kg). Treadmill exercise was conducted for 30 minutes once a day, 5 days per week during 28 days. Step-down avoidance task was done to measure short-term memory. Glial fibrillary acidic protein and ionized calcium binding adaptor molecule 1 were assessed by immunohistochemistry. Expression of adhesion molecules and proinflammatory cytokines was determined by western blot analysis. Results Treadmill exercise alleviated lipid profiles in the P-407-induced hyperlipidemia rats. Treadmill exercise improved short-term memory, inhibited reactive astrogliosis and microglia activation, and suppressed expression of adhesion molecules and proinflammatory cytokines in the hyperlipidemic rats. Conclusions Treadmill exercise exerts alleviating effect on memory deficits by inhibiting hippocampal neuroinflammation in the hyperlipidemia. The current results suggest that treadmill running serves as the treatment strategy for the cognitive dysfunction caused by hyperlipidemia.
format	article
author	Sang-Seo Park Tae-Woon Kim Yun-Hee Sung Yun-Jin Park Myung-Ki Kim Mal-Soon Shin
author_facet	Sang-Seo Park Tae-Woon Kim Yun-Hee Sung Yun-Jin Park Myung-Ki Kim Mal-Soon Shin
author_sort	Sang-Seo Park
title	Treadmill Exercise Ameliorates Short-term Memory Impairment by Suppressing Hippocampal Neuroinflammation in Poloxamer-407-Induced Hyperlipidemia Rats
title_short	Treadmill Exercise Ameliorates Short-term Memory Impairment by Suppressing Hippocampal Neuroinflammation in Poloxamer-407-Induced Hyperlipidemia Rats
title_full	Treadmill Exercise Ameliorates Short-term Memory Impairment by Suppressing Hippocampal Neuroinflammation in Poloxamer-407-Induced Hyperlipidemia Rats
title_fullStr	Treadmill Exercise Ameliorates Short-term Memory Impairment by Suppressing Hippocampal Neuroinflammation in Poloxamer-407-Induced Hyperlipidemia Rats
title_full_unstemmed	Treadmill Exercise Ameliorates Short-term Memory Impairment by Suppressing Hippocampal Neuroinflammation in Poloxamer-407-Induced Hyperlipidemia Rats
title_sort	treadmill exercise ameliorates short-term memory impairment by suppressing hippocampal neuroinflammation in poloxamer-407-induced hyperlipidemia rats
publisher	Korean Continence Society
publishDate	2021
url	https://doaj.org/article/70e0e65459bd4f4e80df7850469ee80d
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Treadmill Exercise Ameliorates Short-term Memory Impairment by Suppressing Hippocampal Neuroinflammation in Poloxamer-407-Induced Hyperlipidemia Rats

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