Metabolic reprogramming by Zika virus provokes inflammation in human placenta

Zika virus (ZIKV) infection of pregnant women is associated with pregnancy loss and birth defects, but molecular insights for the aetiology are scarce. Here the authors show that ZIKV reprograms the host lipidome to facilitate viral replication, induce mitochondria dysfunction, and cause immune imba...

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Autores principales:	Qian Chen, Jordi Gouilly, Yann J. Ferrat, Ana Espino, Quentin Glaziou, Géraldine Cartron, Hicham El Costa, Reem Al-Daccak, Nabila Jabrane-Ferrat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70e1014b73ad480a95726b9d91fc3bd7
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spelling	oai:doaj.org-article:70e1014b73ad480a95726b9d91fc3bd72021-12-02T17:52:20ZMetabolic reprogramming by Zika virus provokes inflammation in human placenta10.1038/s41467-020-16754-z2041-1723https://doaj.org/article/70e1014b73ad480a95726b9d91fc3bd72020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16754-zhttps://doaj.org/toc/2041-1723Zika virus (ZIKV) infection of pregnant women is associated with pregnancy loss and birth defects, but molecular insights for the aetiology are scarce. Here the authors show that ZIKV reprograms the host lipidome to facilitate viral replication, induce mitochondria dysfunction, and cause immune imbalance, thereby identifying a potential target for ZIKV therapy.Qian ChenJordi GouillyYann J. FerratAna EspinoQuentin GlaziouGéraldine CartronHicham El CostaReem Al-DaccakNabila Jabrane-FerratNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian Chen Jordi Gouilly Yann J. Ferrat Ana Espino Quentin Glaziou Géraldine Cartron Hicham El Costa Reem Al-Daccak Nabila Jabrane-Ferrat Metabolic reprogramming by Zika virus provokes inflammation in human placenta
description	Zika virus (ZIKV) infection of pregnant women is associated with pregnancy loss and birth defects, but molecular insights for the aetiology are scarce. Here the authors show that ZIKV reprograms the host lipidome to facilitate viral replication, induce mitochondria dysfunction, and cause immune imbalance, thereby identifying a potential target for ZIKV therapy.
format	article
author	Qian Chen Jordi Gouilly Yann J. Ferrat Ana Espino Quentin Glaziou Géraldine Cartron Hicham El Costa Reem Al-Daccak Nabila Jabrane-Ferrat
author_facet	Qian Chen Jordi Gouilly Yann J. Ferrat Ana Espino Quentin Glaziou Géraldine Cartron Hicham El Costa Reem Al-Daccak Nabila Jabrane-Ferrat
author_sort	Qian Chen
title	Metabolic reprogramming by Zika virus provokes inflammation in human placenta
title_short	Metabolic reprogramming by Zika virus provokes inflammation in human placenta
title_full	Metabolic reprogramming by Zika virus provokes inflammation in human placenta
title_fullStr	Metabolic reprogramming by Zika virus provokes inflammation in human placenta
title_full_unstemmed	Metabolic reprogramming by Zika virus provokes inflammation in human placenta
title_sort	metabolic reprogramming by zika virus provokes inflammation in human placenta
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/70e1014b73ad480a95726b9d91fc3bd7
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Metabolic reprogramming by Zika virus provokes inflammation in human placenta

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