FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction

Abstract It is well recognized that osteocytes communicate with each other via gap junctions and that connxin43 (Cx43) shows its great potential in gap junction for the contribution enabling transmission of small molecules and operating in an autocrine/a paracrine manner. Fibroblast growth factors (...

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Autores principales:	Xiao-Yu Liu, Xin Li, Ming-Ru Bai, Xia Chen, Cheng-Lin Wang, Jing Xie, Ling Ye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Osteocyte Cell Processes Bone Cell Behavior Canonical FGFs Anti-connexin Antibodies Tibial Tissue Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70e1489b640e4c859ebf79c7e7957d70
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spelling	oai:doaj.org-article:70e1489b640e4c859ebf79c7e7957d702021-12-02T15:07:46ZFGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction10.1038/s41598-018-33247-82045-2322https://doaj.org/article/70e1489b640e4c859ebf79c7e7957d702018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33247-8https://doaj.org/toc/2045-2322Abstract It is well recognized that osteocytes communicate with each other via gap junctions and that connxin43 (Cx43) shows its great potential in gap junction for the contribution enabling transmission of small molecules and operating in an autocrine/a paracrine manner. Fibroblast growth factors (FGFs) play significant roles in new bone formation and adult bone remodeling, and FGF signaling is regulated by the precise spatiotemporal approaches. However, the influence of FGF7 on osteocyte cell processes is not well elucidated. In this study, we aimed to examine the impact of FGF7 on osteocyte cell processes by characterizing the expression of Cx43 and to reveal the underlying mechanism regulating this cell process. We first found that the mRNA level of FGF7 was higher relative to other FGF family members both in osteocytes cell line (MLO-Y4) and bone tissue. We then demonstrated that FGF7 could increase the expression of Cx43 in osteocytes and promote the cell processes in the form of gap junctions between osteocytes. This modulation was due to the FGF7-induced cytoplasmic accumulation and resultant nuclear translocation of β-catenin. Our results could help us to further understand the importance of FGF7 on bone cell behavior and bone physiology and even pathology.Xiao-Yu LiuXin LiMing-Ru BaiXia ChenCheng-Lin WangJing XieLing YeNature PortfolioarticleOsteocyte Cell ProcessesBone Cell BehaviorCanonical FGFsAnti-connexin AntibodiesTibial TissueMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Osteocyte Cell Processes Bone Cell Behavior Canonical FGFs Anti-connexin Antibodies Tibial Tissue Medicine R Science Q
spellingShingle	Osteocyte Cell Processes Bone Cell Behavior Canonical FGFs Anti-connexin Antibodies Tibial Tissue Medicine R Science Q Xiao-Yu Liu Xin Li Ming-Ru Bai Xia Chen Cheng-Lin Wang Jing Xie Ling Ye FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction
description	Abstract It is well recognized that osteocytes communicate with each other via gap junctions and that connxin43 (Cx43) shows its great potential in gap junction for the contribution enabling transmission of small molecules and operating in an autocrine/a paracrine manner. Fibroblast growth factors (FGFs) play significant roles in new bone formation and adult bone remodeling, and FGF signaling is regulated by the precise spatiotemporal approaches. However, the influence of FGF7 on osteocyte cell processes is not well elucidated. In this study, we aimed to examine the impact of FGF7 on osteocyte cell processes by characterizing the expression of Cx43 and to reveal the underlying mechanism regulating this cell process. We first found that the mRNA level of FGF7 was higher relative to other FGF family members both in osteocytes cell line (MLO-Y4) and bone tissue. We then demonstrated that FGF7 could increase the expression of Cx43 in osteocytes and promote the cell processes in the form of gap junctions between osteocytes. This modulation was due to the FGF7-induced cytoplasmic accumulation and resultant nuclear translocation of β-catenin. Our results could help us to further understand the importance of FGF7 on bone cell behavior and bone physiology and even pathology.
format	article
author	Xiao-Yu Liu Xin Li Ming-Ru Bai Xia Chen Cheng-Lin Wang Jing Xie Ling Ye
author_facet	Xiao-Yu Liu Xin Li Ming-Ru Bai Xia Chen Cheng-Lin Wang Jing Xie Ling Ye
author_sort	Xiao-Yu Liu
title	FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction
title_short	FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction
title_full	FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction
title_fullStr	FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction
title_full_unstemmed	FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction
title_sort	fgf-7 dictates osteocyte cell processes through beta-catenin transduction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/70e1489b640e4c859ebf79c7e7957d70
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FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction

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