Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.

Mutations in, or elevated dosage of, SNCA, the gene for α-synuclein (α-syn), cause familial Parkinson's disease (PD). Mouse lines overexpressing the mutant human A53Tα-syn may represent a model of early PD. They display progressive motor deficits, abnormal cellular accumulation of α-syn, and de...

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Autores principales: Nicola J Platt, Suzana Gispert, Georg Auburger, Stephanie J Cragg
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/70e3bba895d94bb0ae050cdb506c4310
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