Origin Replication Complex Binding, Nucleosome Depletion Patterns, and a Primary Sequence Motif Can Predict Origins of Replication in a Genome with Epigenetic Centromeres

Origin Replication Complex Binding, Nucleosome Depletion Patterns, and a Primary Sequence Motif Can Predict Origins of Replication in a Genome with Epigenetic Centromeres

ABSTRACT Origins of DNA replication are key genetic elements, yet their identification remains elusive in most organisms. In previous work, we found that centromeres contain origins of replication (ORIs) that are determined epigenetically in the pathogenic yeast Candida albicans. In this study, we u...

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Autores principales: Hung-Ji Tsai, Joshua A. Baller, Ivan Liachko, Amnon Koren, Laura S. Burrack, Meleah A. Hickman, Mathuravani A. Thevandavakkam, Laura N. Rusche, Judith Berman
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/70e68d4e98f34ef9b64f1dcf46320fb4
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