Opioids and Breast Cancer Recurrence: A Systematic Review

Breast cancer has the greatest epidemiological impact in women. Opioids represent the most prescribed analgesics, both in surgical time and in immediate postoperative period, as well as in chronic pain management as palliative care. We made a systematic review analyzing the literature’s evidence abo...

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Autores principales:	Merlino Lucia, Titi Luca, Del Prete Federica, Galli Cecilia, Mandosi Chiara, De Marchis Laura, Della Rocca Carlo, Piccioni Maria Grazia
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	opioids anesthesia breast cancer breast cancer surgery breast cancer recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/70e7829b17264d5d85b56815706643c4
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spelling	oai:doaj.org-article:70e7829b17264d5d85b56815706643c42021-11-11T15:33:44ZOpioids and Breast Cancer Recurrence: A Systematic Review10.3390/cancers132154992072-6694https://doaj.org/article/70e7829b17264d5d85b56815706643c42021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5499https://doaj.org/toc/2072-6694Breast cancer has the greatest epidemiological impact in women. Opioids represent the most prescribed analgesics, both in surgical time and in immediate postoperative period, as well as in chronic pain management as palliative care. We made a systematic review analyzing the literature’s evidence about the safety of opioids in breast cancer treatment, focusing our attention on the link between opioid administration and increased relapses. The research has been conducted using the PubMed database. Preclinical studies, retrospective and prospective clinical studies, review articles and original articles were analyzed. In the literature, there are several preclinical in vitro and in vivo studies, suggesting a possible linkage between opioids administration and progression of cancer disease. Nevertheless, these results are not confirmed by clinical studies. The most recent evidence reassures the safety of opioids during surgical time as analgesic associated with anesthetics drugs, during postoperative period for optimal cancer-related pain management and in chronic use. Currently, there is controversial evidence suggesting a possible impact of opioids on breast cancer progression, but to date, it remains an unresolved issue. Although there is no conclusive evidence, we hope to arouse interest in the scientific community to always ensure the best standards of care for these patients.Merlino LuciaTiti LucaDel Prete FedericaGalli CeciliaMandosi ChiaraDe Marchis LauraDella Rocca CarloPiccioni Maria GraziaMDPI AGarticleopioidsanesthesiabreast cancerbreast cancer surgerybreast cancer recurrenceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5499, p 5499 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	opioids anesthesia breast cancer breast cancer surgery breast cancer recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	opioids anesthesia breast cancer breast cancer surgery breast cancer recurrence Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Merlino Lucia Titi Luca Del Prete Federica Galli Cecilia Mandosi Chiara De Marchis Laura Della Rocca Carlo Piccioni Maria Grazia Opioids and Breast Cancer Recurrence: A Systematic Review
description	Breast cancer has the greatest epidemiological impact in women. Opioids represent the most prescribed analgesics, both in surgical time and in immediate postoperative period, as well as in chronic pain management as palliative care. We made a systematic review analyzing the literature’s evidence about the safety of opioids in breast cancer treatment, focusing our attention on the link between opioid administration and increased relapses. The research has been conducted using the PubMed database. Preclinical studies, retrospective and prospective clinical studies, review articles and original articles were analyzed. In the literature, there are several preclinical in vitro and in vivo studies, suggesting a possible linkage between opioids administration and progression of cancer disease. Nevertheless, these results are not confirmed by clinical studies. The most recent evidence reassures the safety of opioids during surgical time as analgesic associated with anesthetics drugs, during postoperative period for optimal cancer-related pain management and in chronic use. Currently, there is controversial evidence suggesting a possible impact of opioids on breast cancer progression, but to date, it remains an unresolved issue. Although there is no conclusive evidence, we hope to arouse interest in the scientific community to always ensure the best standards of care for these patients.
format	article
author	Merlino Lucia Titi Luca Del Prete Federica Galli Cecilia Mandosi Chiara De Marchis Laura Della Rocca Carlo Piccioni Maria Grazia
author_facet	Merlino Lucia Titi Luca Del Prete Federica Galli Cecilia Mandosi Chiara De Marchis Laura Della Rocca Carlo Piccioni Maria Grazia
author_sort	Merlino Lucia
title	Opioids and Breast Cancer Recurrence: A Systematic Review
title_short	Opioids and Breast Cancer Recurrence: A Systematic Review
title_full	Opioids and Breast Cancer Recurrence: A Systematic Review
title_fullStr	Opioids and Breast Cancer Recurrence: A Systematic Review
title_full_unstemmed	Opioids and Breast Cancer Recurrence: A Systematic Review
title_sort	opioids and breast cancer recurrence: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/70e7829b17264d5d85b56815706643c4
work_keys_str_mv	AT merlinolucia opioidsandbreastcancerrecurrenceasystematicreview AT titiluca opioidsandbreastcancerrecurrenceasystematicreview AT delpretefederica opioidsandbreastcancerrecurrenceasystematicreview AT gallicecilia opioidsandbreastcancerrecurrenceasystematicreview AT mandosichiara opioidsandbreastcancerrecurrenceasystematicreview AT demarchislaura opioidsandbreastcancerrecurrenceasystematicreview AT dellaroccacarlo opioidsandbreastcancerrecurrenceasystematicreview AT piccionimariagrazia opioidsandbreastcancerrecurrenceasystematicreview
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Opioids and Breast Cancer Recurrence: A Systematic Review

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