Unravelling the Anti-Inflammatory and Antioxidant Potential of the Marine Sponge <i>Cliona celata</i> from the Portuguese Coastline

Inflammation is a double-edged sword, as it can have both protective effects and harmful consequences, which, combined with oxidative stress (OS), can lead to the development of deathly chronic inflammatory conditions. Over the years, research has evidenced the potential of marine sponges as a sourc...

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Autores principales:	Joana Alves, Helena Gaspar, Joana Silva, Celso Alves, Alice Martins, Fernando Teodoro, Patrícia Susano, Susete Pinteus, Rui Pedrosa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	marine natural products chronic diseases marine sponges oxidative stress inflammation RAW 264.7.6 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/70e79e7207d342d7bd8ce869214b10b7
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spelling	oai:doaj.org-article:70e79e7207d342d7bd8ce869214b10b72021-11-25T18:12:57ZUnravelling the Anti-Inflammatory and Antioxidant Potential of the Marine Sponge <i>Cliona celata</i> from the Portuguese Coastline10.3390/md191106321660-3397https://doaj.org/article/70e79e7207d342d7bd8ce869214b10b72021-11-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/632https://doaj.org/toc/1660-3397Inflammation is a double-edged sword, as it can have both protective effects and harmful consequences, which, combined with oxidative stress (OS), can lead to the development of deathly chronic inflammatory conditions. Over the years, research has evidenced the potential of marine sponges as a source of effective anti-inflammatory therapeutic agents. Within this framework, the purpose of this study was to evaluate the antioxidant and the anti-inflammatory potential of the marine sponge <i>Cliona celata</i>. For this purpose, their organic extracts (C1–C5) and fractions were evaluated concerning their radical scavenging activity through 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and anti-inflammatory activity through a (lipopolysaccharides (LPS)-induced inflammation on RAW 264.7 cells) model. Compounds present in the two most active fractions (F5 and F13) of C4 were tentatively identified by gas chromatography coupled to mass spectrometry (GC-MS). Even though samples displayed low antioxidant activity, they presented a high anti-inflammatory capacity in the studied cellular inflammatory model when compared to the anti-inflammatory standard, dexamethasone. GC-MS analysis led to the identification of <i>n</i>-hexadecanoic acid, <i>cis</i>-9-hexadecenal, and 13-octadecenal in fraction F5, while two major compounds, octadecanoic acid and cholesterol, were identified in fraction F13. The developed studies demonstrated the high anti-inflammatory activity of the marine sponge <i>C. celata</i> extracts and fractions, highlighting its potential for further therapeutic applications.Joana AlvesHelena GasparJoana SilvaCelso AlvesAlice MartinsFernando TeodoroPatrícia SusanoSusete PinteusRui PedrosaMDPI AGarticlemarine natural productschronic diseasesmarine spongesoxidative stressinflammationRAW 264.7.6Biology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 632, p 632 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	marine natural products chronic diseases marine sponges oxidative stress inflammation RAW 264.7.6 Biology (General) QH301-705.5
spellingShingle	marine natural products chronic diseases marine sponges oxidative stress inflammation RAW 264.7.6 Biology (General) QH301-705.5 Joana Alves Helena Gaspar Joana Silva Celso Alves Alice Martins Fernando Teodoro Patrícia Susano Susete Pinteus Rui Pedrosa Unravelling the Anti-Inflammatory and Antioxidant Potential of the Marine Sponge <i>Cliona celata</i> from the Portuguese Coastline
description	Inflammation is a double-edged sword, as it can have both protective effects and harmful consequences, which, combined with oxidative stress (OS), can lead to the development of deathly chronic inflammatory conditions. Over the years, research has evidenced the potential of marine sponges as a source of effective anti-inflammatory therapeutic agents. Within this framework, the purpose of this study was to evaluate the antioxidant and the anti-inflammatory potential of the marine sponge <i>Cliona celata</i>. For this purpose, their organic extracts (C1–C5) and fractions were evaluated concerning their radical scavenging activity through 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and anti-inflammatory activity through a (lipopolysaccharides (LPS)-induced inflammation on RAW 264.7 cells) model. Compounds present in the two most active fractions (F5 and F13) of C4 were tentatively identified by gas chromatography coupled to mass spectrometry (GC-MS). Even though samples displayed low antioxidant activity, they presented a high anti-inflammatory capacity in the studied cellular inflammatory model when compared to the anti-inflammatory standard, dexamethasone. GC-MS analysis led to the identification of <i>n</i>-hexadecanoic acid, <i>cis</i>-9-hexadecenal, and 13-octadecenal in fraction F5, while two major compounds, octadecanoic acid and cholesterol, were identified in fraction F13. The developed studies demonstrated the high anti-inflammatory activity of the marine sponge <i>C. celata</i> extracts and fractions, highlighting its potential for further therapeutic applications.
format	article
author	Joana Alves Helena Gaspar Joana Silva Celso Alves Alice Martins Fernando Teodoro Patrícia Susano Susete Pinteus Rui Pedrosa
author_facet	Joana Alves Helena Gaspar Joana Silva Celso Alves Alice Martins Fernando Teodoro Patrícia Susano Susete Pinteus Rui Pedrosa
author_sort	Joana Alves
title	Unravelling the Anti-Inflammatory and Antioxidant Potential of the Marine Sponge <i>Cliona celata</i> from the Portuguese Coastline
title_short	Unravelling the Anti-Inflammatory and Antioxidant Potential of the Marine Sponge <i>Cliona celata</i> from the Portuguese Coastline
title_full	Unravelling the Anti-Inflammatory and Antioxidant Potential of the Marine Sponge <i>Cliona celata</i> from the Portuguese Coastline
title_fullStr	Unravelling the Anti-Inflammatory and Antioxidant Potential of the Marine Sponge <i>Cliona celata</i> from the Portuguese Coastline
title_full_unstemmed	Unravelling the Anti-Inflammatory and Antioxidant Potential of the Marine Sponge <i>Cliona celata</i> from the Portuguese Coastline
title_sort	unravelling the anti-inflammatory and antioxidant potential of the marine sponge <i>cliona celata</i> from the portuguese coastline
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/70e79e7207d342d7bd8ce869214b10b7
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Unravelling the Anti-Inflammatory and Antioxidant Potential of the Marine Sponge <i>Cliona celata</i> from the Portuguese Coastline

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