DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation

The coverage and throughput of data-independent acquisition (DIA)-based phosphoproteomics is limited by its dependence on experimental spectral libraries. Here the authors develop a DIA workflow based on in silico spectral libraries generated by a novel deep neural network to expand phosphoproteome...

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Autores principales:	Ronghui Lou, Weizhen Liu, Rongjie Li, Shanshan Li, Xuming He, Wenqing Shui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70e7e24906674cd4a67e2516deeb2150
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spelling	oai:doaj.org-article:70e7e24906674cd4a67e2516deeb21502021-11-21T12:34:18ZDeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation10.1038/s41467-021-26979-12041-1723https://doaj.org/article/70e7e24906674cd4a67e2516deeb21502021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26979-1https://doaj.org/toc/2041-1723The coverage and throughput of data-independent acquisition (DIA)-based phosphoproteomics is limited by its dependence on experimental spectral libraries. Here the authors develop a DIA workflow based on in silico spectral libraries generated by a novel deep neural network to expand phosphoproteome coverage.Ronghui LouWeizhen LiuRongjie LiShanshan LiXuming HeWenqing ShuiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ronghui Lou Weizhen Liu Rongjie Li Shanshan Li Xuming He Wenqing Shui DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation
description	The coverage and throughput of data-independent acquisition (DIA)-based phosphoproteomics is limited by its dependence on experimental spectral libraries. Here the authors develop a DIA workflow based on in silico spectral libraries generated by a novel deep neural network to expand phosphoproteome coverage.
format	article
author	Ronghui Lou Weizhen Liu Rongjie Li Shanshan Li Xuming He Wenqing Shui
author_facet	Ronghui Lou Weizhen Liu Rongjie Li Shanshan Li Xuming He Wenqing Shui
author_sort	Ronghui Lou
title	DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation
title_short	DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation
title_full	DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation
title_fullStr	DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation
title_full_unstemmed	DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation
title_sort	deepphospho accelerates dia phosphoproteome profiling through in silico library generation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/70e7e24906674cd4a67e2516deeb2150
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DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation

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