Association analyses identify 31 new risk loci for colorectal cancer susceptibility
In colorectal cancer (CRC), finding loci associated with risk may give insight into disease aetiology. Here, the authors report a genome-wide association analysis in Europeans of 34,627 CRC cases and 71,379 controls, and find 31 new risk loci and 17 new risk SNPs at previously reported loci.
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Nature Portfolio
2019
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oai:doaj.org-article:70e8e953edd64bddb89636d55f3bc15c2021-12-02T15:35:33ZAssociation analyses identify 31 new risk loci for colorectal cancer susceptibility10.1038/s41467-019-09775-w2041-1723https://doaj.org/article/70e8e953edd64bddb89636d55f3bc15c2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09775-whttps://doaj.org/toc/2041-1723In colorectal cancer (CRC), finding loci associated with risk may give insight into disease aetiology. Here, the authors report a genome-wide association analysis in Europeans of 34,627 CRC cases and 71,379 controls, and find 31 new risk loci and 17 new risk SNPs at previously reported loci.Philip J. LawMaria TimofeevaCeres Fernandez-RozadillaPeter BroderickJames StuddJuan Fernandez-TajesSusan FarringtonVictoria SvintiClaire PallesGiulia OrlandoAmit SudAmy HolroydSteven PenegarEvropi TheodoratouPeter Vaughan-ShawHarry CampbellLina ZgagaCaroline HaywardArchie CampbellSarah HarrisIan J. DearyJohn StarrLaura GatcombeMaria PinnaSarah BriggsLynn MartinEmma JaegerArchana Sharma-OatesJames EastSimon LeedhamRoland ArnoldElaine JohnstoneHaitao WangDavid KerrRachel KerrTim MaughanRichard KaplanNada Al-TassanKimmo PalinUlrika A. HänninenTatiana CajusoTomas TanskanenJohanna KondelinEevi KaasinenAntti-Pekka SarinJohan G. ErikssonHarri RissanenPaul KnektEero PukkalaPekka JousilahtiVeikko SalomaaSamuli RipattiAarno PalotieLaura Renkonen-SinisaloAnna LepistöJan BöhmJukka-Pekka MecklinDaniel D. BuchananAung-Ko WinJohn HopperMark E. JenkinsNoralane M. LindorPolly A. NewcombSteven GallingerDavid DugganGraham CaseyPer HoffmannMarkus M. NöthenKarl-Heinz JöckelDouglas F. EastonPaul D. P. PharoahJulian PetoFederico CanzianAnthony SwerdlowRosalind A. EelesZsofia Kote-JaraiKenneth MuirNora PashayanThe PRACTICAL consortiumAndrea HarkinKaren AllanJohn McQueenJames PaulTimothy IvesonMark SaundersKatja ButterbachJenny Chang-ClaudeMichael HoffmeisterHermann BrennerIva KiracPetar MatoševićPhilipp HoferStefanie BrezinaAndrea GsurJeremy P. CheadleLauri A. AaltonenIan TomlinsonRichard S. HoulstonMalcolm G. DunlopNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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Science Q Philip J. Law Maria Timofeeva Ceres Fernandez-Rozadilla Peter Broderick James Studd Juan Fernandez-Tajes Susan Farrington Victoria Svinti Claire Palles Giulia Orlando Amit Sud Amy Holroyd Steven Penegar Evropi Theodoratou Peter Vaughan-Shaw Harry Campbell Lina Zgaga Caroline Hayward Archie Campbell Sarah Harris Ian J. Deary John Starr Laura Gatcombe Maria Pinna Sarah Briggs Lynn Martin Emma Jaeger Archana Sharma-Oates James East Simon Leedham Roland Arnold Elaine Johnstone Haitao Wang David Kerr Rachel Kerr Tim Maughan Richard Kaplan Nada Al-Tassan Kimmo Palin Ulrika A. Hänninen Tatiana Cajuso Tomas Tanskanen Johanna Kondelin Eevi Kaasinen Antti-Pekka Sarin Johan G. Eriksson Harri Rissanen Paul Knekt Eero Pukkala Pekka Jousilahti Veikko Salomaa Samuli Ripatti Aarno Palotie Laura Renkonen-Sinisalo Anna Lepistö Jan Böhm Jukka-Pekka Mecklin Daniel D. Buchanan Aung-Ko Win John Hopper Mark E. Jenkins Noralane M. Lindor Polly A. Newcomb Steven Gallinger David Duggan Graham Casey Per Hoffmann Markus M. Nöthen Karl-Heinz Jöckel Douglas F. Easton Paul D. P. Pharoah Julian Peto Federico Canzian Anthony Swerdlow Rosalind A. Eeles Zsofia Kote-Jarai Kenneth Muir Nora Pashayan The PRACTICAL consortium Andrea Harkin Karen Allan John McQueen James Paul Timothy Iveson Mark Saunders Katja Butterbach Jenny Chang-Claude Michael Hoffmeister Hermann Brenner Iva Kirac Petar Matošević Philipp Hofer Stefanie Brezina Andrea Gsur Jeremy P. Cheadle Lauri A. Aaltonen Ian Tomlinson Richard S. Houlston Malcolm G. Dunlop Association analyses identify 31 new risk loci for colorectal cancer susceptibility |
| description |
In colorectal cancer (CRC), finding loci associated with risk may give insight into disease aetiology. Here, the authors report a genome-wide association analysis in Europeans of 34,627 CRC cases and 71,379 controls, and find 31 new risk loci and 17 new risk SNPs at previously reported loci. |
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article |
| author |
Philip J. Law Maria Timofeeva Ceres Fernandez-Rozadilla Peter Broderick James Studd Juan Fernandez-Tajes Susan Farrington Victoria Svinti Claire Palles Giulia Orlando Amit Sud Amy Holroyd Steven Penegar Evropi Theodoratou Peter Vaughan-Shaw Harry Campbell Lina Zgaga Caroline Hayward Archie Campbell Sarah Harris Ian J. Deary John Starr Laura Gatcombe Maria Pinna Sarah Briggs Lynn Martin Emma Jaeger Archana Sharma-Oates James East Simon Leedham Roland Arnold Elaine Johnstone Haitao Wang David Kerr Rachel Kerr Tim Maughan Richard Kaplan Nada Al-Tassan Kimmo Palin Ulrika A. Hänninen Tatiana Cajuso Tomas Tanskanen Johanna Kondelin Eevi Kaasinen Antti-Pekka Sarin Johan G. Eriksson Harri Rissanen Paul Knekt Eero Pukkala Pekka Jousilahti Veikko Salomaa Samuli Ripatti Aarno Palotie Laura Renkonen-Sinisalo Anna Lepistö Jan Böhm Jukka-Pekka Mecklin Daniel D. Buchanan Aung-Ko Win John Hopper Mark E. Jenkins Noralane M. Lindor Polly A. Newcomb Steven Gallinger David Duggan Graham Casey Per Hoffmann Markus M. Nöthen Karl-Heinz Jöckel Douglas F. Easton Paul D. P. Pharoah Julian Peto Federico Canzian Anthony Swerdlow Rosalind A. Eeles Zsofia Kote-Jarai Kenneth Muir Nora Pashayan The PRACTICAL consortium Andrea Harkin Karen Allan John McQueen James Paul Timothy Iveson Mark Saunders Katja Butterbach Jenny Chang-Claude Michael Hoffmeister Hermann Brenner Iva Kirac Petar Matošević Philipp Hofer Stefanie Brezina Andrea Gsur Jeremy P. Cheadle Lauri A. Aaltonen Ian Tomlinson Richard S. Houlston Malcolm G. Dunlop |
| author_facet |
Philip J. Law Maria Timofeeva Ceres Fernandez-Rozadilla Peter Broderick James Studd Juan Fernandez-Tajes Susan Farrington Victoria Svinti Claire Palles Giulia Orlando Amit Sud Amy Holroyd Steven Penegar Evropi Theodoratou Peter Vaughan-Shaw Harry Campbell Lina Zgaga Caroline Hayward Archie Campbell Sarah Harris Ian J. Deary John Starr Laura Gatcombe Maria Pinna Sarah Briggs Lynn Martin Emma Jaeger Archana Sharma-Oates James East Simon Leedham Roland Arnold Elaine Johnstone Haitao Wang David Kerr Rachel Kerr Tim Maughan Richard Kaplan Nada Al-Tassan Kimmo Palin Ulrika A. Hänninen Tatiana Cajuso Tomas Tanskanen Johanna Kondelin Eevi Kaasinen Antti-Pekka Sarin Johan G. Eriksson Harri Rissanen Paul Knekt Eero Pukkala Pekka Jousilahti Veikko Salomaa Samuli Ripatti Aarno Palotie Laura Renkonen-Sinisalo Anna Lepistö Jan Böhm Jukka-Pekka Mecklin Daniel D. Buchanan Aung-Ko Win John Hopper Mark E. Jenkins Noralane M. Lindor Polly A. Newcomb Steven Gallinger David Duggan Graham Casey Per Hoffmann Markus M. Nöthen Karl-Heinz Jöckel Douglas F. Easton Paul D. P. Pharoah Julian Peto Federico Canzian Anthony Swerdlow Rosalind A. Eeles Zsofia Kote-Jarai Kenneth Muir Nora Pashayan The PRACTICAL consortium Andrea Harkin Karen Allan John McQueen James Paul Timothy Iveson Mark Saunders Katja Butterbach Jenny Chang-Claude Michael Hoffmeister Hermann Brenner Iva Kirac Petar Matošević Philipp Hofer Stefanie Brezina Andrea Gsur Jeremy P. Cheadle Lauri A. Aaltonen Ian Tomlinson Richard S. Houlston Malcolm G. Dunlop |
| author_sort |
Philip J. Law |
| title |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility |
| title_short |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility |
| title_full |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility |
| title_fullStr |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility |
| title_full_unstemmed |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility |
| title_sort |
association analyses identify 31 new risk loci for colorectal cancer susceptibility |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/70e8e953edd64bddb89636d55f3bc15c |
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