Structural and <italic toggle="yes">In Vivo</italic> Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design

Structural and <italic toggle="yes">In Vivo</italic> Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design

ABSTRACT The disaccharide trehalose is critical to the survival of pathogenic fungi in their human host. Trehalose-6-phosphate synthase (Tps1) catalyzes the first step of trehalose biosynthesis in fungi. Here, we report the first structures of eukaryotic Tps1s in complex with substrates or substrate...

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Autores principales: Yi Miao, Jennifer L. Tenor, Dena L. Toffaletti, Stacey A. Maskarinec, Jiuyu Liu, Richard E. Lee, John R. Perfect, Richard G. Brennan
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
Aspergillus fumigatus
Candida albicans
Tps1
fungal pathogens
structural biology
trehalose
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/70eac0dc7dc945b89231678ac09012a9
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