CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation.

Immune recovery after profound lymphopenia is a major challenge in many clinical situations, such as allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recovery depends, in a first step, on hematopoietic lymphoid progenitors production in the bone marrow (BM). In this study, we characte...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Salomé Glauzy, Isabelle André-Schmutz, Jérôme Larghero, Sophie Ezine, Régis Peffault de Latour, Hélène Moins-Teisserenc, Sophie Servais, Marie Robin, Gérard Socié, Emmanuel Clave, Antoine Toubert
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70eac6067aef47979fdab7b3122e8929
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:70eac6067aef47979fdab7b3122e8929
record_format	dspace
spelling	oai:doaj.org-article:70eac6067aef47979fdab7b3122e89292021-11-18T08:28:31ZCXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation.1932-620310.1371/journal.pone.0091492https://doaj.org/article/70eac6067aef47979fdab7b3122e89292014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24621606/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Immune recovery after profound lymphopenia is a major challenge in many clinical situations, such as allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recovery depends, in a first step, on hematopoietic lymphoid progenitors production in the bone marrow (BM). In this study, we characterized CD34+Lin-CD10+ lymphoid progenitors in the peripheral blood of allo-HSCT patients. Our data demonstrate a strong recovery of this population 3 months after transplantation. This rebound was abolished in patients who developed acute graft-versus-host disease (aGVHD). A similar recovery profile was found for both CD24+ and CD24- progenitor subpopulations. CD34+lin-CD10+CD24- lymphoid progenitors sorted from allo-HSCT patients preserved their T cell potentiel according to in vitro T-cell differentiation assay and the expression profile of 22 genes involved in T-cell differentiation and homing. CD34+lin-CD10+CD24- cells from patients without aGVHD had reduced CXCR4 gene expression, consistent with an enhanced egress from the BM. CCR7 gene expression was reduced in patients after allo-HSCT, as were its ligands CCL21 and CCL19. This reduction was particularly marked in patients with aGVHD, suggesting a possible impact on thymic homing. Thus, the data presented here identify this population as an important early step in T cell reconstitution in humans and so, an important target when seeking to enhance immune reconstitution.Salomé GlauzyIsabelle André-SchmutzJérôme LargheroSophie EzineRégis Peffault de LatourHélène Moins-TeisserencSophie ServaisMarie RobinGérard SociéEmmanuel ClaveAntoine ToubertPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e91492 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Salomé Glauzy Isabelle André-Schmutz Jérôme Larghero Sophie Ezine Régis Peffault de Latour Hélène Moins-Teisserenc Sophie Servais Marie Robin Gérard Socié Emmanuel Clave Antoine Toubert CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation.
description	Immune recovery after profound lymphopenia is a major challenge in many clinical situations, such as allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recovery depends, in a first step, on hematopoietic lymphoid progenitors production in the bone marrow (BM). In this study, we characterized CD34+Lin-CD10+ lymphoid progenitors in the peripheral blood of allo-HSCT patients. Our data demonstrate a strong recovery of this population 3 months after transplantation. This rebound was abolished in patients who developed acute graft-versus-host disease (aGVHD). A similar recovery profile was found for both CD24+ and CD24- progenitor subpopulations. CD34+lin-CD10+CD24- lymphoid progenitors sorted from allo-HSCT patients preserved their T cell potentiel according to in vitro T-cell differentiation assay and the expression profile of 22 genes involved in T-cell differentiation and homing. CD34+lin-CD10+CD24- cells from patients without aGVHD had reduced CXCR4 gene expression, consistent with an enhanced egress from the BM. CCR7 gene expression was reduced in patients after allo-HSCT, as were its ligands CCL21 and CCL19. This reduction was particularly marked in patients with aGVHD, suggesting a possible impact on thymic homing. Thus, the data presented here identify this population as an important early step in T cell reconstitution in humans and so, an important target when seeking to enhance immune reconstitution.
format	article
author	Salomé Glauzy Isabelle André-Schmutz Jérôme Larghero Sophie Ezine Régis Peffault de Latour Hélène Moins-Teisserenc Sophie Servais Marie Robin Gérard Socié Emmanuel Clave Antoine Toubert
author_facet	Salomé Glauzy Isabelle André-Schmutz Jérôme Larghero Sophie Ezine Régis Peffault de Latour Hélène Moins-Teisserenc Sophie Servais Marie Robin Gérard Socié Emmanuel Clave Antoine Toubert
author_sort	Salomé Glauzy
title	CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation.
title_short	CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation.
title_full	CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation.
title_fullStr	CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation.
title_full_unstemmed	CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation.
title_sort	cxcr4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/70eac6067aef47979fdab7b3122e8929
work_keys_str_mv	AT salomeglauzy cxcr4relatedincreaseofcirculatinghumanlymphoidprogenitorsafterallogeneichematopoieticstemcelltransplantation AT isabelleandreschmutz cxcr4relatedincreaseofcirculatinghumanlymphoidprogenitorsafterallogeneichematopoieticstemcelltransplantation AT jeromelarghero cxcr4relatedincreaseofcirculatinghumanlymphoidprogenitorsafterallogeneichematopoieticstemcelltransplantation AT sophieezine cxcr4relatedincreaseofcirculatinghumanlymphoidprogenitorsafterallogeneichematopoieticstemcelltransplantation AT regispeffaultdelatour cxcr4relatedincreaseofcirculatinghumanlymphoidprogenitorsafterallogeneichematopoieticstemcelltransplantation AT helenemoinsteisserenc cxcr4relatedincreaseofcirculatinghumanlymphoidprogenitorsafterallogeneichematopoieticstemcelltransplantation AT sophieservais cxcr4relatedincreaseofcirculatinghumanlymphoidprogenitorsafterallogeneichematopoieticstemcelltransplantation AT marierobin cxcr4relatedincreaseofcirculatinghumanlymphoidprogenitorsafterallogeneichematopoieticstemcelltransplantation AT gerardsocie cxcr4relatedincreaseofcirculatinghumanlymphoidprogenitorsafterallogeneichematopoieticstemcelltransplantation AT emmanuelclave cxcr4relatedincreaseofcirculatinghumanlymphoidprogenitorsafterallogeneichematopoieticstemcelltransplantation AT antoinetoubert cxcr4relatedincreaseofcirculatinghumanlymphoidprogenitorsafterallogeneichematopoieticstemcelltransplantation
_version_	1718421747850543104

CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation.

Ejemplares similares