Early markers of glycaemic control in children with type 1 diabetes mellitus.

<h4>Background</h4>Type 1 diabetes mellitus (T1DM) may lead to severe long-term health consequences. In a longitudinal study, we aimed to identify factors present at diagnosis and 6 months later that were associated with glycosylated haemoglobin (HbA(1c)) levels at 24 months after T1DM d...

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Autores principales:	Samuel W Cutfield, José G B Derraik, Peter W Reed, Paul L Hofman, Craig Jefferies, Wayne S Cutfield
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70eb228967d94ae3b5592405c96b6fd3
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spelling	oai:doaj.org-article:70eb228967d94ae3b5592405c96b6fd32021-11-04T06:07:48ZEarly markers of glycaemic control in children with type 1 diabetes mellitus.1932-620310.1371/journal.pone.0025251https://doaj.org/article/70eb228967d94ae3b5592405c96b6fd32011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21966469/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Type 1 diabetes mellitus (T1DM) may lead to severe long-term health consequences. In a longitudinal study, we aimed to identify factors present at diagnosis and 6 months later that were associated with glycosylated haemoglobin (HbA(1c)) levels at 24 months after T1DM diagnosis, so that diabetic children at risk of poor glycaemic control may be identified.<h4>Methods</h4>229 children <15 years of age diagnosed with T1DM in the Auckland region were studied. Data collected at diagnosis were: age, sex, weight, height, ethnicity, family living arrangement, socio-economic status (SES), T1DM antibody titre, venous pH and bicarbonate. At 6 and 24 months after diagnosis we collected data on weight, height, HbA(1c) level, and insulin dose.<h4>Results</h4>Factors at diagnosis that were associated with higher HbA(1c) levels at 6 months: female sex (p<0.05), lower SES (p<0.01), non-European ethnicity (p<0.01) and younger age (p<0.05). At 24 months, higher HbA(1c) was associated with lower SES (p<0.001), Pacific Island ethnicity (p<0.001), not living with both biological parents (p<0.05), and greater BMI SDS (p<0.05). A regression equation to predict HbA(1c) at 24 months was consequently developed.<h4>Conclusions</h4>Deterioration in glycaemic control shortly after diagnosis in diabetic children is particularly marked in Pacific Island children and in those not living with both biological parents. Clinicians need to be aware of factors associated with poor glycaemic control beyond the remission phase, so that more effective measures can be implemented shortly after diagnosis to prevent deterioration in diabetes control.Samuel W CutfieldJosé G B DerraikPeter W ReedPaul L HofmanCraig JefferiesWayne S CutfieldPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e25251 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Samuel W Cutfield José G B Derraik Peter W Reed Paul L Hofman Craig Jefferies Wayne S Cutfield Early markers of glycaemic control in children with type 1 diabetes mellitus.
description	<h4>Background</h4>Type 1 diabetes mellitus (T1DM) may lead to severe long-term health consequences. In a longitudinal study, we aimed to identify factors present at diagnosis and 6 months later that were associated with glycosylated haemoglobin (HbA(1c)) levels at 24 months after T1DM diagnosis, so that diabetic children at risk of poor glycaemic control may be identified.<h4>Methods</h4>229 children <15 years of age diagnosed with T1DM in the Auckland region were studied. Data collected at diagnosis were: age, sex, weight, height, ethnicity, family living arrangement, socio-economic status (SES), T1DM antibody titre, venous pH and bicarbonate. At 6 and 24 months after diagnosis we collected data on weight, height, HbA(1c) level, and insulin dose.<h4>Results</h4>Factors at diagnosis that were associated with higher HbA(1c) levels at 6 months: female sex (p<0.05), lower SES (p<0.01), non-European ethnicity (p<0.01) and younger age (p<0.05). At 24 months, higher HbA(1c) was associated with lower SES (p<0.001), Pacific Island ethnicity (p<0.001), not living with both biological parents (p<0.05), and greater BMI SDS (p<0.05). A regression equation to predict HbA(1c) at 24 months was consequently developed.<h4>Conclusions</h4>Deterioration in glycaemic control shortly after diagnosis in diabetic children is particularly marked in Pacific Island children and in those not living with both biological parents. Clinicians need to be aware of factors associated with poor glycaemic control beyond the remission phase, so that more effective measures can be implemented shortly after diagnosis to prevent deterioration in diabetes control.
format	article
author	Samuel W Cutfield José G B Derraik Peter W Reed Paul L Hofman Craig Jefferies Wayne S Cutfield
author_facet	Samuel W Cutfield José G B Derraik Peter W Reed Paul L Hofman Craig Jefferies Wayne S Cutfield
author_sort	Samuel W Cutfield
title	Early markers of glycaemic control in children with type 1 diabetes mellitus.
title_short	Early markers of glycaemic control in children with type 1 diabetes mellitus.
title_full	Early markers of glycaemic control in children with type 1 diabetes mellitus.
title_fullStr	Early markers of glycaemic control in children with type 1 diabetes mellitus.
title_full_unstemmed	Early markers of glycaemic control in children with type 1 diabetes mellitus.
title_sort	early markers of glycaemic control in children with type 1 diabetes mellitus.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/70eb228967d94ae3b5592405c96b6fd3
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Early markers of glycaemic control in children with type 1 diabetes mellitus.

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