A case report of Familial Adenomatous Polyposis (FAP)

Background and Objective: Familial adenomatous polyposis (FAP) is an autosomal dominant disease that caused by mutation of the APC gene and in addition to colon, it can involve stomach and duodenum. Since, the risk of malignancy in FAP is high, early diagnosis and treatment can prevent colorectal ca...

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Autores principales:	A Gholizadeh Pasha, SH Savad Koohi, E Shafigh
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2003
Materias:	malignancy familial adenomatous polyposis colon Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/70ebe7db716a4c8897348e6229fa45ce
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spelling	oai:doaj.org-article:70ebe7db716a4c8897348e6229fa45ce2021-11-10T09:18:15ZA case report of Familial Adenomatous Polyposis (FAP)1561-41072251-7170https://doaj.org/article/70ebe7db716a4c8897348e6229fa45ce2003-07-01T00:00:00Zhttp://jbums.org/article-1-2765-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Familial adenomatous polyposis (FAP) is an autosomal dominant disease that caused by mutation of the APC gene and in addition to colon, it can involve stomach and duodenum. Since, the risk of malignancy in FAP is high, early diagnosis and treatment can prevent colorectal cancer. Case: The patient was a 55-year-old man who referred for rectal bleeding and proctalgia from 6 weeks ago. He was examined with anoscope, and rectal mass was observed. In pathological study, rectal adenocarcinoma was reported. B.Enema and total coloscopy were performed for patient and multiple polyps in colorectal were seen. For patient with FAP, total proctocolectomy and permanent ileostomy were performed. There were malignant changes in one sessile polyps with >2.5cm diameter. In colonoscopic examination of patient’s family, 4 of 6 children were with FAP. Conclusion: Although, only 0.5% of all colorectal cancers caused by FAP but early diagnosis and screening in patient’s family can prevent the progress of disease and malignancy.A Gholizadeh PashaSH Savad KoohiE ShafighBabol University of Medical Sciencesarticlemalignancyfamilial adenomatous polyposiscolonMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 5, Iss 3, Pp 63-66 (2003)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	malignancy familial adenomatous polyposis colon Medicine R Medicine (General) R5-920
spellingShingle	malignancy familial adenomatous polyposis colon Medicine R Medicine (General) R5-920 A Gholizadeh Pasha SH Savad Koohi E Shafigh A case report of Familial Adenomatous Polyposis (FAP)
description	Background and Objective: Familial adenomatous polyposis (FAP) is an autosomal dominant disease that caused by mutation of the APC gene and in addition to colon, it can involve stomach and duodenum. Since, the risk of malignancy in FAP is high, early diagnosis and treatment can prevent colorectal cancer. Case: The patient was a 55-year-old man who referred for rectal bleeding and proctalgia from 6 weeks ago. He was examined with anoscope, and rectal mass was observed. In pathological study, rectal adenocarcinoma was reported. B.Enema and total coloscopy were performed for patient and multiple polyps in colorectal were seen. For patient with FAP, total proctocolectomy and permanent ileostomy were performed. There were malignant changes in one sessile polyps with >2.5cm diameter. In colonoscopic examination of patient’s family, 4 of 6 children were with FAP. Conclusion: Although, only 0.5% of all colorectal cancers caused by FAP but early diagnosis and screening in patient’s family can prevent the progress of disease and malignancy.
format	article
author	A Gholizadeh Pasha SH Savad Koohi E Shafigh
author_facet	A Gholizadeh Pasha SH Savad Koohi E Shafigh
author_sort	A Gholizadeh Pasha
title	A case report of Familial Adenomatous Polyposis (FAP)
title_short	A case report of Familial Adenomatous Polyposis (FAP)
title_full	A case report of Familial Adenomatous Polyposis (FAP)
title_fullStr	A case report of Familial Adenomatous Polyposis (FAP)
title_full_unstemmed	A case report of Familial Adenomatous Polyposis (FAP)
title_sort	case report of familial adenomatous polyposis (fap)
publisher	Babol University of Medical Sciences
publishDate	2003
url	https://doaj.org/article/70ebe7db716a4c8897348e6229fa45ce
work_keys_str_mv	AT agholizadehpasha acasereportoffamilialadenomatouspolyposisfap AT shsavadkoohi acasereportoffamilialadenomatouspolyposisfap AT eshafigh acasereportoffamilialadenomatouspolyposisfap AT agholizadehpasha casereportoffamilialadenomatouspolyposisfap AT shsavadkoohi casereportoffamilialadenomatouspolyposisfap AT eshafigh casereportoffamilialadenomatouspolyposisfap
_version_	1718440204907315200

A case report of Familial Adenomatous Polyposis (FAP)

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