Immune tuning scaffold for the local induction of a pro-regenerative environment

Abstract In mammals, tissue regeneration is accomplished through a well-regulated, complex cascade of events. The disruption of the cellular and molecular processes involved in tissue healing might lead to scar formation. Most tissue engineering approaches have tried to improve the regenerative outc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bruna Corradetti, Francesca Taraballi, Claudia Corbo, Fernando Cabrera, Laura Pandolfi, Silvia Minardi, Xin Wang, Jeffrey Van Eps, Guillermo Bauza, Bradley Weiner, Ennio Tasciotti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70eda440368a45dcac409ae54ca49f9d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:70eda440368a45dcac409ae54ca49f9d
record_format	dspace
spelling	oai:doaj.org-article:70eda440368a45dcac409ae54ca49f9d2021-12-02T15:06:14ZImmune tuning scaffold for the local induction of a pro-regenerative environment10.1038/s41598-017-16895-02045-2322https://doaj.org/article/70eda440368a45dcac409ae54ca49f9d2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-16895-0https://doaj.org/toc/2045-2322Abstract In mammals, tissue regeneration is accomplished through a well-regulated, complex cascade of events. The disruption of the cellular and molecular processes involved in tissue healing might lead to scar formation. Most tissue engineering approaches have tried to improve the regenerative outcome following an injury, through the combination of biocompatible materials, stem cells and bioactive factors. However, implanted materials can cause further healing impairments due to the persistent inflammatory stimuli that trigger the onset of chronic inflammation. Here, it is described at the molecular, cellular and tissue level, the body response to a functionalized biomimetic collagen scaffold. The grafting of chondroitin sulfate on the surface of the scaffold is able to induce a pro-regenerative environment at the site of a subcutaneous implant. The early in situ recruitment, and sustained local retention of anti-inflammatory macrophages significantly reduced the pro-inflammatory environment and triggered a different healing cascade, ultimately leading to collagen fibril re-organization, blood vessel formation, and scaffold integration with the surrounding native tissue.Bruna CorradettiFrancesca TaraballiClaudia CorboFernando CabreraLaura PandolfiSilvia MinardiXin WangJeffrey Van EpsGuillermo BauzaBradley WeinerEnnio TasciottiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bruna Corradetti Francesca Taraballi Claudia Corbo Fernando Cabrera Laura Pandolfi Silvia Minardi Xin Wang Jeffrey Van Eps Guillermo Bauza Bradley Weiner Ennio Tasciotti Immune tuning scaffold for the local induction of a pro-regenerative environment
description	Abstract In mammals, tissue regeneration is accomplished through a well-regulated, complex cascade of events. The disruption of the cellular and molecular processes involved in tissue healing might lead to scar formation. Most tissue engineering approaches have tried to improve the regenerative outcome following an injury, through the combination of biocompatible materials, stem cells and bioactive factors. However, implanted materials can cause further healing impairments due to the persistent inflammatory stimuli that trigger the onset of chronic inflammation. Here, it is described at the molecular, cellular and tissue level, the body response to a functionalized biomimetic collagen scaffold. The grafting of chondroitin sulfate on the surface of the scaffold is able to induce a pro-regenerative environment at the site of a subcutaneous implant. The early in situ recruitment, and sustained local retention of anti-inflammatory macrophages significantly reduced the pro-inflammatory environment and triggered a different healing cascade, ultimately leading to collagen fibril re-organization, blood vessel formation, and scaffold integration with the surrounding native tissue.
format	article
author	Bruna Corradetti Francesca Taraballi Claudia Corbo Fernando Cabrera Laura Pandolfi Silvia Minardi Xin Wang Jeffrey Van Eps Guillermo Bauza Bradley Weiner Ennio Tasciotti
author_facet	Bruna Corradetti Francesca Taraballi Claudia Corbo Fernando Cabrera Laura Pandolfi Silvia Minardi Xin Wang Jeffrey Van Eps Guillermo Bauza Bradley Weiner Ennio Tasciotti
author_sort	Bruna Corradetti
title	Immune tuning scaffold for the local induction of a pro-regenerative environment
title_short	Immune tuning scaffold for the local induction of a pro-regenerative environment
title_full	Immune tuning scaffold for the local induction of a pro-regenerative environment
title_fullStr	Immune tuning scaffold for the local induction of a pro-regenerative environment
title_full_unstemmed	Immune tuning scaffold for the local induction of a pro-regenerative environment
title_sort	immune tuning scaffold for the local induction of a pro-regenerative environment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/70eda440368a45dcac409ae54ca49f9d
work_keys_str_mv	AT brunacorradetti immunetuningscaffoldforthelocalinductionofaproregenerativeenvironment AT francescataraballi immunetuningscaffoldforthelocalinductionofaproregenerativeenvironment AT claudiacorbo immunetuningscaffoldforthelocalinductionofaproregenerativeenvironment AT fernandocabrera immunetuningscaffoldforthelocalinductionofaproregenerativeenvironment AT laurapandolfi immunetuningscaffoldforthelocalinductionofaproregenerativeenvironment AT silviaminardi immunetuningscaffoldforthelocalinductionofaproregenerativeenvironment AT xinwang immunetuningscaffoldforthelocalinductionofaproregenerativeenvironment AT jeffreyvaneps immunetuningscaffoldforthelocalinductionofaproregenerativeenvironment AT guillermobauza immunetuningscaffoldforthelocalinductionofaproregenerativeenvironment AT bradleyweiner immunetuningscaffoldforthelocalinductionofaproregenerativeenvironment AT enniotasciotti immunetuningscaffoldforthelocalinductionofaproregenerativeenvironment
_version_	1718388518934282240

Immune tuning scaffold for the local induction of a pro-regenerative environment

Ejemplares similares