OMOLOGICAL AND HETEROLOGICAL ANTIBODY AND T CELL IMMUNE RESPONSES TO LIVE ATTENUATED INFLUENZA VACCINE A (H5N2) AND A (H7N3)

From the beginning of 21th century outbreaks of H5, H7 and H9 avian flu are registered from time to time. These viruses are considered as one of the possible causes of the next pandemia. The development of avian influenza vaccines is one of the WHO priorities. The aim of this work was to study antib...

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Autores principales:	A. N. Naykhin, S. A. Donina, I. V. Losev, G. D. Petukhova, D. A. Korenkov, M. A. Stukova, M. К. Erofeeva, O. S. Konshina, T. A. Smolonogina, Е. М. Doroshenko, E. P. Grigorieva, L. G. Rudenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	avian influenza viruses immune response to influenza a viruses humoral immune response Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/70eec61f7aef48309cf9cfe90340deb0
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spelling	oai:doaj.org-article:70eec61f7aef48309cf9cfe90340deb02021-11-18T08:03:44ZOMOLOGICAL AND HETEROLOGICAL ANTIBODY AND T CELL IMMUNE RESPONSES TO LIVE ATTENUATED INFLUENZA VACCINE A (H5N2) AND A (H7N3)1563-06252313-741X10.15789/1563-0625-2015-1-59-70https://doaj.org/article/70eec61f7aef48309cf9cfe90340deb02015-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/809https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XFrom the beginning of 21th century outbreaks of H5, H7 and H9 avian flu are registered from time to time. These viruses are considered as one of the possible causes of the next pandemia. The development of avian influenza vaccines is one of the WHO priorities. The aim of this work was to study antibody and cellular immune responses to avian A (H5N2) and A (H7N3) live attenuated influenza vaccines (LAIVs). We examined serum antibodies (HAI assay, microneutralization assay, ELISA), local antibodies (ELISA) and virus-specific CD4+ and CD8+ central memory and effector memory T cells. Two doses vaccination of healthy volunteers with A (H5N2) and A (H7N3) LAIVs induced homological antibody and cellular immune responses (i. e. serum and local antibody conversions, virus-specific memory T cell growth). These vaccines also stimulated heterological immunity (heterological serum and local antibodies and T cells). Heterological immune response intensity depended on antigenic structure of vaccine strain and heterological virus, particularly on HA type.A. N. NaykhinS. A. DoninaI. V. LosevG. D. PetukhovaD. A. KorenkovM. A. StukovaM. К. ErofeevaO. S. KonshinaT. A. SmolonoginaЕ. М. DoroshenkoE. P. GrigorievaL. G. RudenkoSPb RAACIarticleavian influenza virusesimmune response to influenza a viruseshumoral immune responseImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 1, Pp 59-70 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	avian influenza viruses immune response to influenza a viruses humoral immune response Immunologic diseases. Allergy RC581-607
spellingShingle	avian influenza viruses immune response to influenza a viruses humoral immune response Immunologic diseases. Allergy RC581-607 A. N. Naykhin S. A. Donina I. V. Losev G. D. Petukhova D. A. Korenkov M. A. Stukova M. К. Erofeeva O. S. Konshina T. A. Smolonogina Е. М. Doroshenko E. P. Grigorieva L. G. Rudenko OMOLOGICAL AND HETEROLOGICAL ANTIBODY AND T CELL IMMUNE RESPONSES TO LIVE ATTENUATED INFLUENZA VACCINE A (H5N2) AND A (H7N3)
description	From the beginning of 21th century outbreaks of H5, H7 and H9 avian flu are registered from time to time. These viruses are considered as one of the possible causes of the next pandemia. The development of avian influenza vaccines is one of the WHO priorities. The aim of this work was to study antibody and cellular immune responses to avian A (H5N2) and A (H7N3) live attenuated influenza vaccines (LAIVs). We examined serum antibodies (HAI assay, microneutralization assay, ELISA), local antibodies (ELISA) and virus-specific CD4+ and CD8+ central memory and effector memory T cells. Two doses vaccination of healthy volunteers with A (H5N2) and A (H7N3) LAIVs induced homological antibody and cellular immune responses (i. e. serum and local antibody conversions, virus-specific memory T cell growth). These vaccines also stimulated heterological immunity (heterological serum and local antibodies and T cells). Heterological immune response intensity depended on antigenic structure of vaccine strain and heterological virus, particularly on HA type.
format	article
author	A. N. Naykhin S. A. Donina I. V. Losev G. D. Petukhova D. A. Korenkov M. A. Stukova M. К. Erofeeva O. S. Konshina T. A. Smolonogina Е. М. Doroshenko E. P. Grigorieva L. G. Rudenko
author_facet	A. N. Naykhin S. A. Donina I. V. Losev G. D. Petukhova D. A. Korenkov M. A. Stukova M. К. Erofeeva O. S. Konshina T. A. Smolonogina Е. М. Doroshenko E. P. Grigorieva L. G. Rudenko
author_sort	A. N. Naykhin
title	OMOLOGICAL AND HETEROLOGICAL ANTIBODY AND T CELL IMMUNE RESPONSES TO LIVE ATTENUATED INFLUENZA VACCINE A (H5N2) AND A (H7N3)
title_short	OMOLOGICAL AND HETEROLOGICAL ANTIBODY AND T CELL IMMUNE RESPONSES TO LIVE ATTENUATED INFLUENZA VACCINE A (H5N2) AND A (H7N3)
title_full	OMOLOGICAL AND HETEROLOGICAL ANTIBODY AND T CELL IMMUNE RESPONSES TO LIVE ATTENUATED INFLUENZA VACCINE A (H5N2) AND A (H7N3)
title_fullStr	OMOLOGICAL AND HETEROLOGICAL ANTIBODY AND T CELL IMMUNE RESPONSES TO LIVE ATTENUATED INFLUENZA VACCINE A (H5N2) AND A (H7N3)
title_full_unstemmed	OMOLOGICAL AND HETEROLOGICAL ANTIBODY AND T CELL IMMUNE RESPONSES TO LIVE ATTENUATED INFLUENZA VACCINE A (H5N2) AND A (H7N3)
title_sort	omological and heterological antibody and t cell immune responses to live attenuated influenza vaccine a (h5n2) and a (h7n3)
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/70eec61f7aef48309cf9cfe90340deb0
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OMOLOGICAL AND HETEROLOGICAL ANTIBODY AND T CELL IMMUNE RESPONSES TO LIVE ATTENUATED INFLUENZA VACCINE A (H5N2) AND A (H7N3)

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