Locomotion and disaggregation control of paramagnetic nanoclusters using wireless electromagnetic fields for enhanced targeted drug delivery

Abstract Magnetic nanorobots (MNRs) based on paramagnetic nanoparticles/nanoclusters for the targeted therapeutics of anticancer drugs have been highlighted for their efficiency potential. Controlling the locomotion of the MNRs is a key challenge for effective delivery to the target legions. Here, w...

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Autores principales:	Kim Tien Nguyen, Gwangjun Go, Jin Zhen, Manh Cuong Hoang, Byungjeon Kang, Eunpyo Choi, Jong-Oh Park, Chang-Sei Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70f2beed0ecc4adcbe5653cd00b5ffdb
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spelling	oai:doaj.org-article:70f2beed0ecc4adcbe5653cd00b5ffdb2021-12-02T17:55:13ZLocomotion and disaggregation control of paramagnetic nanoclusters using wireless electromagnetic fields for enhanced targeted drug delivery10.1038/s41598-021-94446-42045-2322https://doaj.org/article/70f2beed0ecc4adcbe5653cd00b5ffdb2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94446-4https://doaj.org/toc/2045-2322Abstract Magnetic nanorobots (MNRs) based on paramagnetic nanoparticles/nanoclusters for the targeted therapeutics of anticancer drugs have been highlighted for their efficiency potential. Controlling the locomotion of the MNRs is a key challenge for effective delivery to the target legions. Here, we present a method for controlling paramagnetic nanoclusters through enhanced tumbling and disaggregation motions with a combination of rotating field and gradient field generated by external electromagnets. The mechanism is carried out via an electromagnetic actuation system capable of generating MNR motions with five degrees of freedom in a spherical workspace without singularity. The nanocluster swarm structures can successfully pass through channels to the target region where they can disaggregate. The results show significantly faster response and higher targeting rate by using rotating magnetic and gradient fields. The mean velocities of the enhanced tumbling motion are twice those of the conventional tumbling motion and approximately 130% higher than the gradient pulling motion. The effects of each fundamental factor on the locomotion are investigated for further MNR applications. The locomotion speed of the MNR could be predicted by the proposed mathematical model and agrees well with experimental results. The high access rate and disaggregation performance insights the potentials for targeted drug delivery application.Kim Tien NguyenGwangjun GoJin ZhenManh Cuong HoangByungjeon KangEunpyo ChoiJong-Oh ParkChang-Sei KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kim Tien Nguyen Gwangjun Go Jin Zhen Manh Cuong Hoang Byungjeon Kang Eunpyo Choi Jong-Oh Park Chang-Sei Kim Locomotion and disaggregation control of paramagnetic nanoclusters using wireless electromagnetic fields for enhanced targeted drug delivery
description	Abstract Magnetic nanorobots (MNRs) based on paramagnetic nanoparticles/nanoclusters for the targeted therapeutics of anticancer drugs have been highlighted for their efficiency potential. Controlling the locomotion of the MNRs is a key challenge for effective delivery to the target legions. Here, we present a method for controlling paramagnetic nanoclusters through enhanced tumbling and disaggregation motions with a combination of rotating field and gradient field generated by external electromagnets. The mechanism is carried out via an electromagnetic actuation system capable of generating MNR motions with five degrees of freedom in a spherical workspace without singularity. The nanocluster swarm structures can successfully pass through channels to the target region where they can disaggregate. The results show significantly faster response and higher targeting rate by using rotating magnetic and gradient fields. The mean velocities of the enhanced tumbling motion are twice those of the conventional tumbling motion and approximately 130% higher than the gradient pulling motion. The effects of each fundamental factor on the locomotion are investigated for further MNR applications. The locomotion speed of the MNR could be predicted by the proposed mathematical model and agrees well with experimental results. The high access rate and disaggregation performance insights the potentials for targeted drug delivery application.
format	article
author	Kim Tien Nguyen Gwangjun Go Jin Zhen Manh Cuong Hoang Byungjeon Kang Eunpyo Choi Jong-Oh Park Chang-Sei Kim
author_facet	Kim Tien Nguyen Gwangjun Go Jin Zhen Manh Cuong Hoang Byungjeon Kang Eunpyo Choi Jong-Oh Park Chang-Sei Kim
author_sort	Kim Tien Nguyen
title	Locomotion and disaggregation control of paramagnetic nanoclusters using wireless electromagnetic fields for enhanced targeted drug delivery
title_short	Locomotion and disaggregation control of paramagnetic nanoclusters using wireless electromagnetic fields for enhanced targeted drug delivery
title_full	Locomotion and disaggregation control of paramagnetic nanoclusters using wireless electromagnetic fields for enhanced targeted drug delivery
title_fullStr	Locomotion and disaggregation control of paramagnetic nanoclusters using wireless electromagnetic fields for enhanced targeted drug delivery
title_full_unstemmed	Locomotion and disaggregation control of paramagnetic nanoclusters using wireless electromagnetic fields for enhanced targeted drug delivery
title_sort	locomotion and disaggregation control of paramagnetic nanoclusters using wireless electromagnetic fields for enhanced targeted drug delivery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/70f2beed0ecc4adcbe5653cd00b5ffdb
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_version_	1718379114258235392

Locomotion and disaggregation control of paramagnetic nanoclusters using wireless electromagnetic fields for enhanced targeted drug delivery

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