Programming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet

Abstract Alteration of programming of the intestinal wall maturation may be responsible for non-communicable chronic diseases in adulthood. It may originate from prenatal exposure of mothers to deleterious environmental factors such as pesticides or western diet. This work was undertaken to determin...

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Autores principales:	Marion Guibourdenche, Hiba El Khayat El Sabbouri, Narimane Djekkoun, Hafida Khorsi-Cauet, Véronique Bach, Pauline M. Anton, Jérôme Gay-Quéheillard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/70f2c70eb52942da9514f86bf247ab65
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spelling	oai:doaj.org-article:70f2c70eb52942da9514f86bf247ab652021-12-02T17:50:41ZProgramming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet10.1038/s41598-021-90981-22045-2322https://doaj.org/article/70f2c70eb52942da9514f86bf247ab652021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90981-2https://doaj.org/toc/2045-2322Abstract Alteration of programming of the intestinal wall maturation may be responsible for non-communicable chronic diseases in adulthood. It may originate from prenatal exposure of mothers to deleterious environmental factors such as pesticides or western diet. This work was undertaken to determine whether disturbances of the digestive tract function and of innate immunity of offspring at adulthood could be due to maternal exposure to a pesticide, chlorpyrifos (CPF) and a High Fat Diet (HFD) starting 4 months before gestation and lasting until weaning of offspring. Fifty-one male Wistar rats coming from 4 groups of dams exposed to CPF, HFD, both and control were followed from birth to 8 weeks of age. They were fed standard chow and received no treatment. The maternal pesticide exposure slows down fetal and postnatal weight gain without histological injuries of the gut mucosa. CPF or HFD both induced modifications of tight junctions and mucins genes expressions without inducing an increase in epithelial permeability or an inflammatory state. Co-exposure to both CPF and HFD did not exacerbate the effects observed with each factor separately. Despite the lack of direct contact except through breast milk until weaning, CPF or HFD maternal exposure have demonstrated preliminary gut barrier impacts on offspring.Marion GuibourdencheHiba El Khayat El SabbouriNarimane DjekkounHafida Khorsi-CauetVéronique BachPauline M. AntonJérôme Gay-QuéheillardNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marion Guibourdenche Hiba El Khayat El Sabbouri Narimane Djekkoun Hafida Khorsi-Cauet Véronique Bach Pauline M. Anton Jérôme Gay-Quéheillard Programming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet
description	Abstract Alteration of programming of the intestinal wall maturation may be responsible for non-communicable chronic diseases in adulthood. It may originate from prenatal exposure of mothers to deleterious environmental factors such as pesticides or western diet. This work was undertaken to determine whether disturbances of the digestive tract function and of innate immunity of offspring at adulthood could be due to maternal exposure to a pesticide, chlorpyrifos (CPF) and a High Fat Diet (HFD) starting 4 months before gestation and lasting until weaning of offspring. Fifty-one male Wistar rats coming from 4 groups of dams exposed to CPF, HFD, both and control were followed from birth to 8 weeks of age. They were fed standard chow and received no treatment. The maternal pesticide exposure slows down fetal and postnatal weight gain without histological injuries of the gut mucosa. CPF or HFD both induced modifications of tight junctions and mucins genes expressions without inducing an increase in epithelial permeability or an inflammatory state. Co-exposure to both CPF and HFD did not exacerbate the effects observed with each factor separately. Despite the lack of direct contact except through breast milk until weaning, CPF or HFD maternal exposure have demonstrated preliminary gut barrier impacts on offspring.
format	article
author	Marion Guibourdenche Hiba El Khayat El Sabbouri Narimane Djekkoun Hafida Khorsi-Cauet Véronique Bach Pauline M. Anton Jérôme Gay-Quéheillard
author_facet	Marion Guibourdenche Hiba El Khayat El Sabbouri Narimane Djekkoun Hafida Khorsi-Cauet Véronique Bach Pauline M. Anton Jérôme Gay-Quéheillard
author_sort	Marion Guibourdenche
title	Programming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet
title_short	Programming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet
title_full	Programming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet
title_fullStr	Programming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet
title_full_unstemmed	Programming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet
title_sort	programming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/70f2c70eb52942da9514f86bf247ab65
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Programming of intestinal homeostasis in male rat offspring after maternal exposure to chlorpyrifos and/or to a high fat diet

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