Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors

The immunostimulatory properties of TLR7/8 agonists, such as resiquimod, have been exploited for cancer immunotherapy. Here, the authors design platelet membrane-cloaked nanoparticles for selective intratumoral delivery of resiquimod, resulting in potent anti-tumor immune response in a range of prec...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Baharak Bahmani, Hua Gong, Brian T. Luk, Kristofer J. Haushalter, Ethel DeTeresa, Mark Previti, Jiarong Zhou, Weiwei Gao, Jack D. Bui, Liangfang Zhang, Ronnie H. Fang, Jie Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70f51776b4444f01b293b1d2b1518bff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:70f51776b4444f01b293b1d2b1518bff
record_format	dspace
spelling	oai:doaj.org-article:70f51776b4444f01b293b1d2b1518bff2021-12-02T13:27:02ZIntratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors10.1038/s41467-021-22311-z2041-1723https://doaj.org/article/70f51776b4444f01b293b1d2b1518bff2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22311-zhttps://doaj.org/toc/2041-1723The immunostimulatory properties of TLR7/8 agonists, such as resiquimod, have been exploited for cancer immunotherapy. Here, the authors design platelet membrane-cloaked nanoparticles for selective intratumoral delivery of resiquimod, resulting in potent anti-tumor immune response in a range of preclinical solid tumors.Baharak BahmaniHua GongBrian T. LukKristofer J. HaushalterEthel DeTeresaMark PrevitiJiarong ZhouWeiwei GaoJack D. BuiLiangfang ZhangRonnie H. FangJie ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Baharak Bahmani Hua Gong Brian T. Luk Kristofer J. Haushalter Ethel DeTeresa Mark Previti Jiarong Zhou Weiwei Gao Jack D. Bui Liangfang Zhang Ronnie H. Fang Jie Zhang Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
description	The immunostimulatory properties of TLR7/8 agonists, such as resiquimod, have been exploited for cancer immunotherapy. Here, the authors design platelet membrane-cloaked nanoparticles for selective intratumoral delivery of resiquimod, resulting in potent anti-tumor immune response in a range of preclinical solid tumors.
format	article
author	Baharak Bahmani Hua Gong Brian T. Luk Kristofer J. Haushalter Ethel DeTeresa Mark Previti Jiarong Zhou Weiwei Gao Jack D. Bui Liangfang Zhang Ronnie H. Fang Jie Zhang
author_facet	Baharak Bahmani Hua Gong Brian T. Luk Kristofer J. Haushalter Ethel DeTeresa Mark Previti Jiarong Zhou Weiwei Gao Jack D. Bui Liangfang Zhang Ronnie H. Fang Jie Zhang
author_sort	Baharak Bahmani
title	Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
title_short	Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
title_full	Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
title_fullStr	Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
title_full_unstemmed	Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
title_sort	intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/70f51776b4444f01b293b1d2b1518bff
work_keys_str_mv	AT baharakbahmani intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT huagong intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT briantluk intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT kristoferjhaushalter intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT etheldeteresa intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT markpreviti intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT jiarongzhou intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT weiweigao intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT jackdbui intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT liangfangzhang intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT ronniehfang intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors AT jiezhang intratumoralimmunotherapyusingplateletcloakednanoparticlesenhancesantitumorimmunityinsolidtumors
_version_	1718393036920061952

Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors

Ejemplares similares