Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

Imbalance of microglial phenotypes in the aging brain might underlie their involvement in late onset neurodegenerative diseases. Here we report the population structure of microglia in the aged human brain and the reduction of a particular microglia subset in individuals with Alzheimer’s disease ....

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Autores principales:	Marta Olah, Vilas Menon, Naomi Habib, Mariko F. Taga, Yiyi Ma, Christina J. Yung, Maria Cimpean, Anthony Khairallah, Guillermo Coronas-Samano, Roman Sankowski, Dominic Grün, Alexandra A. Kroshilina, Danielle Dionne, Rani A. Sarkis, Garth R. Cosgrove, Jeffrey Helgager, Jeffrey A. Golden, Page B. Pennell, Marco Prinz, Jean Paul G. Vonsattel, Andrew F. Teich, Julie A. Schneider, David A. Bennett, Aviv Regev, Wassim Elyaman, Elizabeth M. Bradshaw, Philip L. De Jager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/70f5aedb5f20425e97be8410947e4a81
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spelling	oai:doaj.org-article:70f5aedb5f20425e97be8410947e4a812021-12-02T17:31:41ZSingle cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease10.1038/s41467-020-19737-22041-1723https://doaj.org/article/70f5aedb5f20425e97be8410947e4a812020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19737-2https://doaj.org/toc/2041-1723Imbalance of microglial phenotypes in the aging brain might underlie their involvement in late onset neurodegenerative diseases. Here we report the population structure of microglia in the aged human brain and the reduction of a particular microglia subset in individuals with Alzheimer’s disease .Marta OlahVilas MenonNaomi HabibMariko F. TagaYiyi MaChristina J. YungMaria CimpeanAnthony KhairallahGuillermo Coronas-SamanoRoman SankowskiDominic GrünAlexandra A. KroshilinaDanielle DionneRani A. SarkisGarth R. CosgroveJeffrey HelgagerJeffrey A. GoldenPage B. PennellMarco PrinzJean Paul G. VonsattelAndrew F. TeichJulie A. SchneiderDavid A. BennettAviv RegevWassim ElyamanElizabeth M. BradshawPhilip L. De JagerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marta Olah Vilas Menon Naomi Habib Mariko F. Taga Yiyi Ma Christina J. Yung Maria Cimpean Anthony Khairallah Guillermo Coronas-Samano Roman Sankowski Dominic Grün Alexandra A. Kroshilina Danielle Dionne Rani A. Sarkis Garth R. Cosgrove Jeffrey Helgager Jeffrey A. Golden Page B. Pennell Marco Prinz Jean Paul G. Vonsattel Andrew F. Teich Julie A. Schneider David A. Bennett Aviv Regev Wassim Elyaman Elizabeth M. Bradshaw Philip L. De Jager Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
description	Imbalance of microglial phenotypes in the aging brain might underlie their involvement in late onset neurodegenerative diseases. Here we report the population structure of microglia in the aged human brain and the reduction of a particular microglia subset in individuals with Alzheimer’s disease .
format	article
author	Marta Olah Vilas Menon Naomi Habib Mariko F. Taga Yiyi Ma Christina J. Yung Maria Cimpean Anthony Khairallah Guillermo Coronas-Samano Roman Sankowski Dominic Grün Alexandra A. Kroshilina Danielle Dionne Rani A. Sarkis Garth R. Cosgrove Jeffrey Helgager Jeffrey A. Golden Page B. Pennell Marco Prinz Jean Paul G. Vonsattel Andrew F. Teich Julie A. Schneider David A. Bennett Aviv Regev Wassim Elyaman Elizabeth M. Bradshaw Philip L. De Jager
author_facet	Marta Olah Vilas Menon Naomi Habib Mariko F. Taga Yiyi Ma Christina J. Yung Maria Cimpean Anthony Khairallah Guillermo Coronas-Samano Roman Sankowski Dominic Grün Alexandra A. Kroshilina Danielle Dionne Rani A. Sarkis Garth R. Cosgrove Jeffrey Helgager Jeffrey A. Golden Page B. Pennell Marco Prinz Jean Paul G. Vonsattel Andrew F. Teich Julie A. Schneider David A. Bennett Aviv Regev Wassim Elyaman Elizabeth M. Bradshaw Philip L. De Jager
author_sort	Marta Olah
title	Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
title_short	Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
title_full	Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
title_fullStr	Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
title_full_unstemmed	Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
title_sort	single cell rna sequencing of human microglia uncovers a subset associated with alzheimer’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/70f5aedb5f20425e97be8410947e4a81
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Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

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