Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases
Manlin Qi,1,2 Minghan Chi,1,2 Xiaolin Sun,1,2 Xianju Xie,3,4 Michael D Weir,4 Thomas W Oates,4 Yanmin Zhou,1,2 Lin Wang,1,2,4 Yuxing Bai,3 Hockin HK Xu4–61Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, People’s Republic of...
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Dove Medical Press
2019
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oai:doaj.org-article:70f8515c85ef4eda97d2ce8731373a3a2021-12-02T11:05:11ZNovel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases1178-2013https://doaj.org/article/70f8515c85ef4eda97d2ce8731373a3a2019-08-01T00:00:00Zhttps://www.dovepress.com/novel-nanomaterial-based-antibacterial-photodynamic-therapies-to-comba-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Manlin Qi,1,2 Minghan Chi,1,2 Xiaolin Sun,1,2 Xianju Xie,3,4 Michael D Weir,4 Thomas W Oates,4 Yanmin Zhou,1,2 Lin Wang,1,2,4 Yuxing Bai,3 Hockin HK Xu4–61Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, People’s Republic of China; 2Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering, Changchun 130021, People’s Republic of China; 3Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, People’s Republic of China; 4Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; 5Center for Stem Cell Biology and Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; 6University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USACorrespondence: Lin Wang; Yanmin ZhouDepartment of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, People’s Republic of ChinaTel +86 4 318 879 6025Email wanglin1982@jlu.edu.cn; zhouym@jlu.edu.cn Abstract: Oral diseases such as tooth caries, periodontal diseases, endodontic infections, etc., are prevalent worldwide. The heavy burden of oral infectious diseases and their consequences on the patients’ quality of life indicates a strong need for developing effective therapies. Advanced understandings of such oral diseases, e.g., inflammatory periodontal lesions, have raised the demand for antibacterial therapeutic strategies, because these diseases are caused by viruses and bacteria. The application of antimicrobial photodynamic therapy (aPDT) on oral infectious diseases has attracted tremendous interest in the past decade. However, aPDT had a minimal effect on the viability of organized biofilms due to the hydrophobic nature of the majority of the photosensitizers (PSs). Therefore, novel nanotechnologies were rapidly developed to target the delivery of hydrophobic PSs into microorganisms for the antimicrobial performance improvement of aPDT. This review focuses on the state-of-the-art of nanomaterials applications in aPDT against oral infectious diseases. The first part of this article focuses on the cutting-edge research on the synthesis, toxicity, and therapeutic effects of various forms of nanomaterials serving as PS carriers for aPDT applications. The second part discusses nanomaterials applications for aPDT in treatments of oral diseases. These novel bioactive nanomaterials have demonstrated great potential to serve as carriers for PSs to substantially enhance the PDT therapeutic effects. Furthermore, the novel aPDT applications not only have exciting therapeutic potential to inhibit bacterial plaque-initiated oral diseases, but also have a wide applicability to other biomedical and tissue engineering applications.Keywords: photodynamic therapy, nanomaterials, antibacterial, anti-inflammatory, upconversion nanoparticles, oral diseasesQi MChi MSun XXie XWeir MDOates TWZhou YWang LBai YXu HHKDove Medical Pressarticlephotodynamic therapynanomaterialsantibacterialanti-inflammatoryupconversion nanoparticlesoral diseasesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 6937-6956 (2019) |
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photodynamic therapy nanomaterials antibacterial anti-inflammatory upconversion nanoparticles oral diseases Medicine (General) R5-920 |
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photodynamic therapy nanomaterials antibacterial anti-inflammatory upconversion nanoparticles oral diseases Medicine (General) R5-920 Qi M Chi M Sun X Xie X Weir MD Oates TW Zhou Y Wang L Bai Y Xu HHK Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases |
| description |
Manlin Qi,1,2 Minghan Chi,1,2 Xiaolin Sun,1,2 Xianju Xie,3,4 Michael D Weir,4 Thomas W Oates,4 Yanmin Zhou,1,2 Lin Wang,1,2,4 Yuxing Bai,3 Hockin HK Xu4–61Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, People’s Republic of China; 2Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering, Changchun 130021, People’s Republic of China; 3Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, People’s Republic of China; 4Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; 5Center for Stem Cell Biology and Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; 6University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USACorrespondence: Lin Wang; Yanmin ZhouDepartment of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, People’s Republic of ChinaTel +86 4 318 879 6025Email wanglin1982@jlu.edu.cn; zhouym@jlu.edu.cn
Abstract: Oral diseases such as tooth caries, periodontal diseases, endodontic infections, etc., are prevalent worldwide. The heavy burden of oral infectious diseases and their consequences on the patients’ quality of life indicates a strong need for developing effective therapies. Advanced understandings of such oral diseases, e.g., inflammatory periodontal lesions, have raised the demand for antibacterial therapeutic strategies, because these diseases are caused by viruses and bacteria. The application of antimicrobial photodynamic therapy (aPDT) on oral infectious diseases has attracted tremendous interest in the past decade. However, aPDT had a minimal effect on the viability of organized biofilms due to the hydrophobic nature of the majority of the photosensitizers (PSs). Therefore, novel nanotechnologies were rapidly developed to target the delivery of hydrophobic PSs into microorganisms for the antimicrobial performance improvement of aPDT. This review focuses on the state-of-the-art of nanomaterials applications in aPDT against oral infectious diseases. The first part of this article focuses on the cutting-edge research on the synthesis, toxicity, and therapeutic effects of various forms of nanomaterials serving as PS carriers for aPDT applications. The second part discusses nanomaterials applications for aPDT in treatments of oral diseases. These novel bioactive nanomaterials have demonstrated great potential to serve as carriers for PSs to substantially enhance the PDT therapeutic effects. Furthermore, the novel aPDT applications not only have exciting therapeutic potential to inhibit bacterial plaque-initiated oral diseases, but also have a wide applicability to other biomedical and tissue engineering applications.Keywords: photodynamic therapy, nanomaterials, antibacterial, anti-inflammatory, upconversion nanoparticles, oral diseases |
| format |
article |
| author |
Qi M Chi M Sun X Xie X Weir MD Oates TW Zhou Y Wang L Bai Y Xu HHK |
| author_facet |
Qi M Chi M Sun X Xie X Weir MD Oates TW Zhou Y Wang L Bai Y Xu HHK |
| author_sort |
Qi M |
| title |
Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases |
| title_short |
Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases |
| title_full |
Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases |
| title_fullStr |
Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases |
| title_full_unstemmed |
Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases |
| title_sort |
novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/70f8515c85ef4eda97d2ce8731373a3a |
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