An Open-Label Prospective Study to Compare the Efficacy and Safety of Topical Fluticasone Versus Tacrolimus in the Proactive Treatment of Atopic Dermatitis

Background: Atopic dermatitis (AD), a chronic recurrent inflammatory skin condition primarily affects children. Topical treatment, systemic treatment, and phototherapy are mainstay of treatment. Objectives: Topical corticosteroids (TCS) are the first line therapy for AD but are associated with v...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vinodhini R. Mudaliyar, Asha Pathak, Alok Dixit, Sweta Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2020
Materias:	topical corticosteroids topical calcineurin inhibitors fluticasone propionate tacrolimus atopic dermatitis Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/70fba1fbb75742c4ba50fdd3406297b3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:70fba1fbb75742c4ba50fdd3406297b3
record_format	dspace
spelling	oai:doaj.org-article:70fba1fbb75742c4ba50fdd3406297b32021-11-17T08:28:31ZAn Open-Label Prospective Study to Compare the Efficacy and Safety of Topical Fluticasone Versus Tacrolimus in the Proactive Treatment of Atopic Dermatitis10.5826/dpc.1004a942160-9381https://doaj.org/article/70fba1fbb75742c4ba50fdd3406297b32020-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1242https://doaj.org/toc/2160-9381 Background: Atopic dermatitis (AD), a chronic recurrent inflammatory skin condition primarily affects children. Topical treatment, systemic treatment, and phototherapy are mainstay of treatment. Objectives: Topical corticosteroids (TCS) are the first line therapy for AD but are associated with various adverse effects. Topical calcineurin inhibitor (TCI) can be used as an alternative to TCS. The aim of the study is to compare efficacy of topical preparation of fluticasone and tacrolimus in lowering the severity of disease, to assess the quality of life (QoL), and to estimate if any association exists between them. Methods: 37 AD children, randomly received either of the two topical treatments, daily application for first 4 week of in acute phase and twice weekly for next 4 week as maintenance phase. The severity of disease was assessed using SCORing Atopic Dermatitis (SCORAD) and QoL was assessed by using Children’s Dermatology Life Quality Index (CDLQI). Results: At the end of acute phase, there was reduction in SCORAD score by 69.29% in fluticasone and 64.20% in tacrolimus group (P<0.001). In maintenance phase, the score had risen in fluticasone group by a mean difference of 0.81 while in tacrolimus, it decreased by 0.99. Both fluticasone and tacrolimus groups improved children’s QoL (P<0.001). Positive correlation (r=0.4668) exists between the SCORAD and QoL. Skin burning was the most common ADR seen with tacrolimus. Conclusions: Fluticasone and tacrolimus are equally efficacious in the treatment of AD, with similar benefits on children’s QoL. Tacrolimus is better in reducing the extent of lesions than fluticasone Vinodhini R. MudaliyarAsha PathakAlok DixitSweta KumarMattioli1885articletopical corticosteroidstopical calcineurin inhibitorsfluticasone propionatetacrolimusatopic dermatitisDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 10, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	topical corticosteroids topical calcineurin inhibitors fluticasone propionate tacrolimus atopic dermatitis Dermatology RL1-803
spellingShingle	topical corticosteroids topical calcineurin inhibitors fluticasone propionate tacrolimus atopic dermatitis Dermatology RL1-803 Vinodhini R. Mudaliyar Asha Pathak Alok Dixit Sweta Kumar An Open-Label Prospective Study to Compare the Efficacy and Safety of Topical Fluticasone Versus Tacrolimus in the Proactive Treatment of Atopic Dermatitis
description	Background: Atopic dermatitis (AD), a chronic recurrent inflammatory skin condition primarily affects children. Topical treatment, systemic treatment, and phototherapy are mainstay of treatment. Objectives: Topical corticosteroids (TCS) are the first line therapy for AD but are associated with various adverse effects. Topical calcineurin inhibitor (TCI) can be used as an alternative to TCS. The aim of the study is to compare efficacy of topical preparation of fluticasone and tacrolimus in lowering the severity of disease, to assess the quality of life (QoL), and to estimate if any association exists between them. Methods: 37 AD children, randomly received either of the two topical treatments, daily application for first 4 week of in acute phase and twice weekly for next 4 week as maintenance phase. The severity of disease was assessed using SCORing Atopic Dermatitis (SCORAD) and QoL was assessed by using Children’s Dermatology Life Quality Index (CDLQI). Results: At the end of acute phase, there was reduction in SCORAD score by 69.29% in fluticasone and 64.20% in tacrolimus group (P<0.001). In maintenance phase, the score had risen in fluticasone group by a mean difference of 0.81 while in tacrolimus, it decreased by 0.99. Both fluticasone and tacrolimus groups improved children’s QoL (P<0.001). Positive correlation (r=0.4668) exists between the SCORAD and QoL. Skin burning was the most common ADR seen with tacrolimus. Conclusions: Fluticasone and tacrolimus are equally efficacious in the treatment of AD, with similar benefits on children’s QoL. Tacrolimus is better in reducing the extent of lesions than fluticasone
format	article
author	Vinodhini R. Mudaliyar Asha Pathak Alok Dixit Sweta Kumar
author_facet	Vinodhini R. Mudaliyar Asha Pathak Alok Dixit Sweta Kumar
author_sort	Vinodhini R. Mudaliyar
title	An Open-Label Prospective Study to Compare the Efficacy and Safety of Topical Fluticasone Versus Tacrolimus in the Proactive Treatment of Atopic Dermatitis
title_short	An Open-Label Prospective Study to Compare the Efficacy and Safety of Topical Fluticasone Versus Tacrolimus in the Proactive Treatment of Atopic Dermatitis
title_full	An Open-Label Prospective Study to Compare the Efficacy and Safety of Topical Fluticasone Versus Tacrolimus in the Proactive Treatment of Atopic Dermatitis
title_fullStr	An Open-Label Prospective Study to Compare the Efficacy and Safety of Topical Fluticasone Versus Tacrolimus in the Proactive Treatment of Atopic Dermatitis
title_full_unstemmed	An Open-Label Prospective Study to Compare the Efficacy and Safety of Topical Fluticasone Versus Tacrolimus in the Proactive Treatment of Atopic Dermatitis
title_sort	open-label prospective study to compare the efficacy and safety of topical fluticasone versus tacrolimus in the proactive treatment of atopic dermatitis
publisher	Mattioli1885
publishDate	2020
url	https://doaj.org/article/70fba1fbb75742c4ba50fdd3406297b3
work_keys_str_mv	AT vinodhinirmudaliyar anopenlabelprospectivestudytocomparetheefficacyandsafetyoftopicalfluticasoneversustacrolimusintheproactivetreatmentofatopicdermatitis AT ashapathak anopenlabelprospectivestudytocomparetheefficacyandsafetyoftopicalfluticasoneversustacrolimusintheproactivetreatmentofatopicdermatitis AT alokdixit anopenlabelprospectivestudytocomparetheefficacyandsafetyoftopicalfluticasoneversustacrolimusintheproactivetreatmentofatopicdermatitis AT swetakumar anopenlabelprospectivestudytocomparetheefficacyandsafetyoftopicalfluticasoneversustacrolimusintheproactivetreatmentofatopicdermatitis AT vinodhinirmudaliyar openlabelprospectivestudytocomparetheefficacyandsafetyoftopicalfluticasoneversustacrolimusintheproactivetreatmentofatopicdermatitis AT ashapathak openlabelprospectivestudytocomparetheefficacyandsafetyoftopicalfluticasoneversustacrolimusintheproactivetreatmentofatopicdermatitis AT alokdixit openlabelprospectivestudytocomparetheefficacyandsafetyoftopicalfluticasoneversustacrolimusintheproactivetreatmentofatopicdermatitis AT swetakumar openlabelprospectivestudytocomparetheefficacyandsafetyoftopicalfluticasoneversustacrolimusintheproactivetreatmentofatopicdermatitis
_version_	1718425804827787264

An Open-Label Prospective Study to Compare the Efficacy and Safety of Topical Fluticasone Versus Tacrolimus in the Proactive Treatment of Atopic Dermatitis

Ejemplares similares